Abstract:
:Monozygotic (MZ) twins discordant for complex diseases may help to find disease mechanisms that are not due to genetic variants. Intermittent allergic rhinitis (IAR) is an optimal disease model because it occurs at defined time points each year, owing to known external antigens. We hypothesized that MZ twins discordant for IAR could help to find gene expression differences that are not dependent on genetic variants. We collected blood outside of the season from MZ twins discordant for IAR, challenged their peripheral blood mononuclear cells (PBMC) with pollen allergen in vitro, collected supernatants and isolated CD4+ T cells. We identified disease-relevant mRNAs and proteins that differed between the discordant MZ twins. By contrast, no differences in microRNA expression were found. Our results indicate that MZ twins discordant for IAR is an optimal model to identify disease mechanisms that are not due to genetic variants.
journal_name
Allergyjournal_title
Allergyauthors
Sjogren AK,Barrenas F,Muraro A,Gustafsson M,Saetrom P,Wang H,Benson Mdoi
10.1111/j.1398-9995.2012.02828.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
831-3issue
6eissn
0105-4538issn
1398-9995journal_volume
67pub_type
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