Abstract:
BACKGROUND:Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS:In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Safety was assessed evaluating local reactions, systemic reactions and adverse events. The clinical effect of LPP was determined by reactivity to the conjunctival provocation test (CPT). Specific IgE, IgG4 and blocking antibodies were measured at baseline (V1), during (V6) and after treatment (V8). RESULTS:No fatality, serious adverse event or epinephrine use was reported. Mean wheal diameters after injections were <0.6 cm and mean redness diameters <2.5 cm, independent of dose. Transient and mostly mild adverse events were reported in 33 patients. Two patients experienced a grade I and 4 patients a grade II reaction (AWMF classification). At V8, 69.8% of patients became nonreactive to CPT. sIgG4 levels were higher at V6 (8.1-fold, P < .001) and V8 (12.2-fold, P < .001) than at V1. The sIgE:sIgG4 ratio decreased at V6 (-54.6%, P < .001) and V8 (-71.6%, P < .001) compared to V1. The absolute decrease in IgE-facilitated allergen binding was 18% (P < .001) at V6 and 25% (P < .001) at V8. CONCLUSION:Increasing doses of subcutaneous LPP appeared safe, substantially diminished reactivity to CPT and induced blocking antibodies as early as 4 weeks after treatment initiation. The benefit/risk balance of LPP immunotherapy remains to be further evaluated in large studies.
journal_name
Allergyjournal_title
Allergyauthors
Mösges R,Koch AF,Raskopf E,Singh J,Shah-Hosseini K,Astvatsatourov A,Hauswald B,Yarin Y,Corazza F,Haazen L,Pirotton S,Allekotte S,Zadoyan G,Legon T,Durham SR,Shamji MHdoi
10.1111/all.13392subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1254-1262issue
6eissn
0105-4538issn
1398-9995journal_volume
73pub_type
杂志文章相关文献
ALLERGY文献大全abstract::Respiratory allergies and subclinical sensitization to aeroallergens were investigated in 129 rural and in 222 urban probands. The incidence of respiratory allergies was not significantly higher in the urban residents. Sensitization to aeroallergens was investigated with Phadezym RAST (house dust mite, Cladosporium, o...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1989.tb04202.x
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Chitotriosidase (chitinase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. However, the role and the mechanisms that underlie these contributions to the diseases have not been...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13426
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The world's most catastrophic and deadly thunderstorm asthma epidemic struck Melbourne, Australia, on November 21, 2016. OBJECTIVE:Among thunderstorm-affected patients presenting to emergency rooms (ERs), we investigated risk factors predicting severe attacks requiring admission to hospital. METHODS:Thunde...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/all.13609
更新日期:2019-01-01 00:00:00
abstract::Delayed-type, T cell-mediated, drug hypersensitivity reactions are a serious unwanted manifestation of drug exposure that develops in a small percentage of the human population. Drugs and drug metabolites are known to interact directly and indirectly (through irreversible protein binding and processing to the derived ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14127
更新日期:2020-04-01 00:00:00
abstract:RATIONALE:The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control. OBJECTIVES:To study the degree of CRS c...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12983
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Cold contact urticaria (CCU) is characterized by itchy wheal and flare responses due to the release of histamine and other pro-inflammatory mediators after exposure to cold. The treatment of choice is nonsedating antihistamines, dosages of which may be increased up to fourfold if standard doses are ineffecti...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.12171
更新日期:2013-07-01 00:00:00
abstract::Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. ...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.1998.tb03890.x
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Allergic diseases have become a major public health problem in developed countries; yet, no reliable, safe and consistently effective treatment is available. DNA immunization has been shown to prevent and balance established allergic responses, however, the high dose of conventional DNA vaccines necessary fo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01142.x
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Fluticasone furoate is a novel-enhanced affinity glucocorticoid and its long-term safety must be assessed. This study was designed to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR). METHO...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2007.01521.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Information about the influence of housing and occupant characteristics on mite allergen concentrations is crucial to determine which methods could be used to decrease exposure of susceptible subjects. OBJECTIVES:To identify housing and occupant characteristics that are associated with mite allergen concent...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00470.x
更新日期:2004-06-01 00:00:00
abstract::Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. T...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1981.tb01850.x
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Vernal keratoconjunctivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficacious treatment. The aims of the study were to determine quantities and distribution of Hsp chaperones in the conjunctiva of VKC patients and assess their levels in conjunctival epithelial an...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12814
更新日期:2016-03-01 00:00:00
abstract::Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01336.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Skin prick tests (SPTs) play an important role in the diagnosis of baker's asthma and in the investigation of sensitization frequencies in field studies. It was the aim of our study to compare different SPT solutions for wheat and rye flour sensitization and to assess the validity of test results. METHODS:S...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1046/j.1398-9995.2003.00349.x
更新日期:2004-01-01 00:00:00
abstract::The clinical effects in asthma of corticosteroids can be ascribed to their strong anti-inflammatory action. The pathophysiology of asthma is complex. A diversity of mediators and interactions between mediators and between mediators and various cell types enhances and maintains the inflammatory process in the airways r...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1988.tb00908.x
更新日期:1988-08-01 00:00:00
abstract::Ispaghula powder, which is used as a component in bulk laxatives, is known to induce allergic reactions when inhaled by occupationally exposed persons. We have tested whether nurses sensitized by inhalation could get allergic symptoms when challenged by eating ispaghula. Of six nurses tested, all developed symptoms fr...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1984.tb01934.x
更新日期:1984-01-01 00:00:00
abstract::The protective effect of terfenadine on inflammatory processes following the early phase of conjunctival provocation tests by specific allergen was assessed in 24 patients suffering from seasonal allergic rhinoconjunctivitis, in a single-blind, randomized, placebo-controlled, parallel-group study. Patients were random...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1992.tb02059.x
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Occurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling. METHODS:Tertiary allergy, dermatology and paediatric units in 10 European...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12475
更新日期:2014-10-01 00:00:00
abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1990.tb00466.x
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Partial mattress encasing was found to be effective in reducing exposure to mite allergen in our previous investigation. We aimed to compare the short-term efficacy of partial and complete mattress encasing and to study mite-allergen levels within these mattresses. METHODS:Thirty-one mattresses with high mi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00060.x
更新日期:1999-07-01 00:00:00
abstract::The objective was to present a case of periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), summarize the medical literature on PFAPA, review the differential diagnosis and suggest a diagnostic approach to periodic fevers in children. A PubMed search was conducted for all case reports an...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01534.x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Immunoglobulin E (IgE)-mediated allergy belongs to common chronic disorders resulting from an interaction between both genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31.1, a region that is linked to asthma and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00271.x
更新日期:2003-10-01 00:00:00
abstract::The phenotypes and receptors of the intraepithelial lymphocytes which are a major component of the mucosal immune system are of considerable interest. Intraepithelial lymphocytes, especially those of the intestines, are well documented. The nasal intraepithelial lymphocytes probably play a key role in the immune defen...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb00693.x
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5-nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and ornidazole and to determine possib...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14542
更新日期:2020-08-05 00:00:00
abstract::House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies, could detect 0.5-1.5 ng/ml of specific ant...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1992.tb05092.x
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Physicians typically rely heavily on self-reported symptoms to make a diagnosis of exercise-induced bronchoconstriction (EIB). However, in elite sport, respiratory symptoms have poor diagnostic value. In 2009, following a change in international sports regulations, all elite athletes suspected of asthma and/...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02762.x
更新日期:2012-03-01 00:00:00
abstract::In a study conducted 1 year ago, we found that Th1 immune enhancement following Bacille Calmette-Guérin (BCG) vaccination effectively suppressed human asthma. To investigate whether revaccination would further improve lung function, BCG vaccine was given again. Current lung function tended to improve in the Repeated B...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1034/j.1398-9995.2003.00246.x
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02444.x
更新日期:2011-01-01 00:00:00
abstract::Dialysed extracts of alder (Alnus glutinosa) and hazel (Corylus avellana) pollens were characterized by immunochemical methods. The alder pollen extract contained at least 33 distinct antigens of which one, antigen 5, was classified as a major allergen, three, antigens 4, 10, and 17, were classified as intermediate al...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1985.tb00259.x
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Specific oral tolerance induction (SOTI) seems to be a promising treatment of food allergy. Specific oral tolerance induction and elimination diet were compared with respect to efficacy rate and patterns of clinical reaction. METHODS:Children with challenge proven immunoglobulin E (IgE)-mediated cow's milk ...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2007.01501.x
更新日期:2007-11-01 00:00:00