Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis.

abstract：BACKGROUND:Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demeth...

journal_title：Allergy

authors： Hinz D,Bauer M,Röder S,Olek S,Huehn J,Sack U,Borte M,Simon JC,Lehmann I,Herberth G,LINA study group.

更新日期：2012-03-01 00:00:00

abstract：:Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, ...

journal_title：Allergy

authors： Stefanovic N,Flohr C,Irvine AD

更新日期：2020-01-01 00:00:00

abstract：:Since the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosapros...

journal_title：Allergy

authors： Canonica GW,Ciprandi G

更新日期：1989-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity rea...

journal_title：Allergy

authors： Kowalski ML,Makowska JS,Blanca M,Bavbek S,Bochenek G,Bousquet J,Bousquet P,Celik G,Demoly P,Gomes ER,Niżankowska-Mogilnicka E,Romano A,Sanchez-Borges M,Sanz M,Torres MJ,De Weck A,Szczeklik A,Brockow K

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...

journal_title：Allergy

authors： Suaini NHA,Wang Y,Soriano VX,Martino DJ,Allen KJ,Ellis JA,Koplin JJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Gliadins have been implicated in immunoglobulin E (IgE)-mediated allergy to ingested wheat and omega-5-gliadin is known to represent a major allergen in wheat-dependent exercise-induced anaphylaxis. Less known is whether omega-5-gliadin is a clinically relevant allergen in children with immediate allergy to ...

journal_title：Allergy

authors： Ito K,Futamura M,Borres MP,Takaoka Y,Dahlstrom J,Sakamoto T,Tanaka A,Kohno K,Matsuo H,Morita E

更新日期：2008-11-01 00:00:00

abstract：:Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...

journal_title：Allergy

authors： Einarsson R,Annerhed A,Karlsson R,Olsson B,Renck B

更新日期：1982-05-01 00:00:00

abstract：RATIONALE:Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects of treatments. OBJECTIVE:To use grass pollen nasal allergen challenge (NAC) to investigate the effects of allergen immunotherapy in a cross-sectional study. METHODS:We studied nasal and cutaneous ...

journal_title：Allergy

authors： Scadding GW,Eifan AO,Lao-Araya M,Penagos M,Poon SY,Steveling E,Yan R,Switzer A,Phippard D,Togias A,Shamji MH,Durham SR

更新日期：2015-06-01 00:00:00

abstract：:The eosinophilic granulocyte is commonly associated with allergic inflammation. Although blood eosinophilia frequently accompanies atopic dermatitis, accumulation of tissue eosinophils is not prominent. Recent studies have elucidated the structure, content, and activities of the eosinophil. In addition, immunofluoresc...

journal_title：Allergy

authors： Leiferman KM

更新日期：1989-01-01 00:00:00

abstract：:It is suggested that eosinophils (Eos) play an important role in the pathogenesis of bronchial asthma by releasing cytotoxic cationic eosinophil granule proteins and damaging bronchial epithelial cells. However, the exact nature of the actual inducer of eosinophil degranulation in vivo is unclear. We examined eosinoph...

journal_title：Allergy

authors： Takafuji S,Tadokoro K,Ito K

更新日期：1996-08-01 00:00:00

abstract：:The ability of common environmental allergens to stimulate IgE responses and thus to produce allergic diseases has tended to overshadow the fact that helminthic parasites are possibly the most potent inducers of this immunoglobulin that exists in nature. Although it has been well established that during these infectio...

journal_title：Allergy

authors： Mingomataj EC,Xhixha F,Gjata E

更新日期：2006-04-01 00:00:00

abstract：:The connective tissue disorders (also called collagen vascular diseases) represent an heterogeneous group of immunologically mediated inflammatory disorders with a large variety of affected organs besides the lungs. The respiratory system may be involved in all its components: airways, vessels, parenchyma, pleura, res...

journal_title：Allergy

authors： Crestani B

更新日期：2005-06-01 00:00:00

abstract：:Eosinophil cationic protein (ECP) is a cationic protein secreted by eosinophils with toxic properties for the respiratory epithelium. Sputum-ECP levels have been shown to correlate inversely with airflow obstruction in asthma. In the present study we investigated whether ECP concentrations are different between asthma...

journal_title：Allergy

authors： Virchow JC Jr,Kroegel C,Hage U,Kortsik C,Matthys H,Werner P

更新日期：1993-01-01 00:00:00

abstract：:The concentration of house-dust mites (Dermatophagoides pteronyssinus) was investigated in 96 Danish homes with one or more members suffering from asthma. The air-exchange rates, humidity, and temperature were measured in all the homes. A positive correlation was found between indoor air humidity and mite concentratio...

journal_title：Allergy

authors： Harving H,Korsgaard J,Dahl R

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Genomewide association studies (GWASs) of asthma have identified single-nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to identify susceptibilit...

journal_title：Allergy

authors： Nieuwenhuis MA,Siedlinski M,van den Berge M,Granell R,Li X,Niens M,van der Vlies P,Altmüller J,Nürnberg P,Kerkhof M,van Schayck OC,Riemersma RA,van der Molen T,de Monchy JG,Bossé Y,Sandford A,Bruijnzeel-Koomen CA,Gerth

更新日期：2016-12-01 00:00:00

abstract：:CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against...

journal_title：Allergy

authors： Cosmi L,Liotta F,Maggi E,Romagnani S,Annunziato F

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Retrospective studies provide evidence that rhinitis is associated with more severe asthma. The aim of this study was to evaluate prospectively whether rhinitis is a predictor of increased asthma severity. METHODS:Five hundred and fifty-seven patients with severe asthma were enrolled. During 1 year of follo...

journal_title：Allergy

authors： Ponte EV,Franco R,Nascimento HF,Souza-Machado A,Cunha S,Barreto ML,Naspitz C,Cruz AA

更新日期：2008-05-01 00:00:00

abstract：:In a double blind study, alcohol/onion extract (5% ethanol) was injected simultaneously with 20 IU and 200 IU rabbit anti-human-IgE intradermally in 12 adult volunteers (6 atopics, 6 non-atopics). Diameters of wheals and flares were measured 10 min after and compared with control sites challenged with 20 IU and 200 IU...

journal_title：Allergy

authors： Dorsch W,Ring J

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Olive tree (Olea europaea) pollen is an important cause of pollinosis in the countries of the Mediterranean area. OBJECTIVE:This work aimed to study the IgE-binding frequency of Ole e 1, Ole e 2, Ole e 3, Ole e 6 and Ole e 7 from O. europaea pollen in a large population of olive pollen-allergic patients. M...

journal_title：Allergy

authors： Quiralte J,Florido F,Arias de Saavedra JM,Gómez A,Sáenz de San Pedro B,González E,Rodríguez R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Variable airflow obstruction and airway hyperresponsiveness (AHR) are features of asthma, which are absent in nonasthmatic eosinophilic bronchitis (EB). Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometr...

journal_title：Allergy

authors： Siddiqui S,Gupta S,Cruse G,Haldar P,Entwisle J,Mcdonald S,Whithers PJ,Hainsworth SV,Coxson HO,Brightling C

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Signal transduction pathways mediated by various receptors expressed on mast cells are thought to be complex, and inhibitory signals that turn off activating signals are not known. METHODS:Upstream signaling cascades mediated by several known receptors in bone marrow-derived mast cells that lead to degranul...

journal_title：Allergy

authors： Chang HW,Kanegasaki S,Jin F,Deng Y,You Z,Chang JH,Kim DY,Timilshina M,Kim JR,Lee YJ,Toyama-Sorimachi N,Tsuchiya T

更新日期：2020-06-01 00:00:00

abstract：:A total of 139 workers (71% of the available work force) in four grain elevator stores in Aalborg, Denmark, participated in a cross-sectional study on the prevalence of storage mite allergy among grain elevator workers. All underwent interview, prick test with a standard panel of allergens and the storage mites Acarus...

journal_title：Allergy

authors： Revsbech P,Andersen G

更新日期：1987-08-01 00:00:00

abstract：:Although allergen immunotherapy (IT) has been shown to modulate allergic hypersensitivities, its efficacy is limited. Recently, in various models of experimental allergy, a number of reagents which we have termed immunostimulatory DNA-based therapeutics have proven highly effective in both the prevention and reversal ...

journal_title：Allergy

authors： Horner AA,Takabaysahi K,Zubeldia JM,Raz E

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...

journal_title：Allergy

authors： Hebenstreit D,Ferreira F

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated the presence of toll-like receptor 9 in the nasal mucosa of both healthy and allergic individuals. CpG motifs, found in bacterial and viral DNA, elicit strong immunostimulatory effects via this receptor. CpG is known to skew the immune system towards a T helper 1 (Th1) profile...

journal_title：Allergy

authors： Månsson A,Bachar O,Adner M,Cardell LO

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5Ralpha) isoform, or a secreted (SOL IL-5Ralpha) isoform, on both protein and transcript level in vitro and in vivo. METHODS:A real-time PCR, FACS and ELISA were establ...

journal_title：Allergy

authors： Gevaert P,Hellman C,Lundblad L,Lundahl J,Holtappels G,van Cauwenberge P,Tavernier J,Bachert C

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Allergic asthma is a multifactorial and probably multigenic inflammatory disease of the upper airways, and has been associated with the HLA class II alleles DR4 and DR7. Here we investigated possible associations with other polymorphic susceptibility/resistance genes located within the major histocompatibili...

journal_title：Allergy

authors： Aron Y,Busson M,Polla BS,Dusser D,Lockhart A,Swierczewski E,Favatier F

更新日期：1999-02-01 00:00:00

abstract：:For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...

journal_title：Allergy

authors： Kort HS,Kniest FM

更新日期：1994-02-01 00:00:00

abstract：:Antigenic extracts prepared from pollen samples collected at weekly intervals during the same season did not exhibit significant variation in protein concentration. Stored pollen samples from different years, however, showed highly significant variations in protein concentration. The protein content of samples from di...

journal_title：Allergy

authors： Malik P,Singh AB,Gangal SV,Babu CR

更新日期：1991-05-01 00:00:00