Abstract:
BACKGROUND:Allergic asthma is a multifactorial and probably multigenic inflammatory disease of the upper airways, and has been associated with the HLA class II alleles DR4 and DR7. Here we investigated possible associations with other polymorphic susceptibility/resistance genes located within the major histocompatibility complex, i.e., the genes coding the major 70-kDa heat-shock proteins (HSP; Hsp70) hsp70-1, hsp70-2, and hsp70-HOM, whose products are overexpressed in the bronchi of asthmatic patients. METHODS:Genomic DNA was extracted from peripheral blood lymphocytes or buccal epithelial cells of 48 patients with allergic asthma and 31 selected nonatopic control subjects, in whom we previously reported a strong association of atopy with DR4/DR7 alleles. RESULTS:No evidence was found for an independent role of hsp70 gene polymorphism in susceptibility to allergic asthma. However, hsp70 alleles might be involved in extended haplotypes of HLA markers. CONCLUSIONS:Our data suggest that Hsp70 overexpression in asthma results from complex interactions between environmental exposures and genetic background rather than from specific genetic variations in hsp70 genes.
journal_name
Allergyjournal_title
Allergyauthors
Aron Y,Busson M,Polla BS,Dusser D,Lockhart A,Swierczewski E,Favatier Fdoi
10.1034/j.1398-9995.1999.00859.xkeywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
165-70issue
2eissn
0105-4538issn
1398-9995journal_volume
54pub_type
杂志文章相关文献
ALLERGY文献大全abstract:BACKGROUND:Allergic diseases have become a major public health problem in developed countries; yet, no reliable, safe and consistently effective treatment is available. DNA immunization has been shown to prevent and balance established allergic responses, however, the high dose of conventional DNA vaccines necessary fo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01142.x
更新日期:2006-07-01 00:00:00
abstract::We studied the allergen composition in an extract of the storage mite Lepidoglyphus destructor. Monoclonal antibodies (mAbs) were raised against L. destructor by a standard hybridoma technique. In the subsequent screening, we concentrated on mAbs fulfilling three criteria. First, in ELISA, mAbs were assessed against a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00129.x
更新日期:1994-09-01 00:00:00
abstract::Quantitative determinations of the inflammatory mediators in nasal secretions were performed and correlated with the objective nasal symptoms within 1 h after nasal allergen challenge (NAC). Twenty-six patients with seasonal allergic rhinitis were enrolled outside the pollen season. All measurements were performed bef...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb00970.x
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:The complex pathogenesis of atopic dermatitis (AD) is guided by cell surface receptor-mediated signal transduction regulated in lipid rafts. Miltefosine is a raft-modulating molecule targeting cell membranes. With this controlled clinical study, the clinical and immunomodulatory efficacy of miltefosine was i...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2010.02341.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families, and their friends. METHODS:The web-based 'Colours Of Risks' (COR) questionnaire...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13095
更新日期:2017-07-01 00:00:00
abstract::In summary, beta 2-adrenergic agonists and corticosteroids can interact to produce beneficial effects on airway function. The regular use of short-acting, beta 2-adrenergic agonists as relief therapy is safe and effective; however, some degree of caution may be required with the use of very high doses. Long-acting bet...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb04887.x
更新日期:1998-01-01 00:00:00
abstract::The aim of the present investigation was to study the dose response relationship of allergen, histamine and histamine releasers in skin prick test (SPT) and the precision of the SPT method. In one experiment timothy allergen, histamine HCl, rabbit anti-human-IgE and compound 48/80 were studied in seven patients. In a ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb02369.x
更新日期:1987-02-01 00:00:00
abstract::The clinical scoring systems of atopic dermatitis were analysed and compared. Some biological parameters that can correlate with the clinical score were also reviewed. After the definition of the disease based on validated clinical criteria, the second necessity was the availability of reliable severity scores to allo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00651.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Children with spina bifida (SB) are exposed to latex soon after birth during bladder catheterization, rectal disimpaction, and multiple surgical procedures. IgE-mediated latex-allergic reactions have been reported recently in these children. Our study was designed to assess the prevalence of allergic reactio...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00683.x
更新日期:1999-01-01 00:00:00
abstract::The estimation of exposure to molds and their products in the indoor environment, which may lead to the occurrence of allergies or respiratory complaints, by means of enumeration of viable parts is inadequate. Therefore, other methods must be developed. When grown under various circumstances (22 degrees C and 30 degre...
journal_title:Allergy
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality-of-life charact...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/all.13141
更新日期:2017-09-01 00:00:00
abstract::Pityrosporum orbiculare and Candida albicans extracts were separated by SDS-PAGE, and IgE binding was detected by immunoblotting with 21 patient sera that were RAST positive to both yeasts. Cross-wise inhibition was performed of IgE binding of a serum pool containing IgE antibodies to both yeasts. The pool was mixed w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb02581.x
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02361.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:A favorable outcome of anaphylaxis depends on the rapidity of adequate initial management and epinephrine injection. However, few data on the management of anaphylactic reactions are available. The aim of this study was to investigate the management and awareness of anaphylaxis to foods by mean of an Interne...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056006540.x
更新日期:2001-06-01 00:00:00
abstract::For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00813.x
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined. PATIENTS AND METHODS:We evaluated the diagnost...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.2007.01351.x
更新日期:2007-07-01 00:00:00
abstract::Although mediators, such as lipids, cytokines, and chemokines, are related to the appearance of an IPR, there has been no reliable indicator to predict conditions for the appearance of an IPR. In this study, we adopted a proteomic approach to investigate the pathogenesis at the level of the plasma proteins and to deve...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01817.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The effectiveness of acaricides in homes is controversial. OBJECTIVE:To determine whether disodium octaborate tetrahydrate (DOT) combined with vacuuming lowers dust mite numbers and their allergens in carpets and sofas. METHODS:A 6-month study was carried out with 93 homes, which were randomized into three...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.2003.00100.x
更新日期:2003-04-01 00:00:00
abstract::The protective effect of terfenadine on inflammatory processes following the early phase of conjunctival provocation tests by specific allergen was assessed in 24 patients suffering from seasonal allergic rhinoconjunctivitis, in a single-blind, randomized, placebo-controlled, parallel-group study. Patients were random...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1992.tb02059.x
更新日期:1992-08-01 00:00:00
abstract::The bronchial epithelium acts as a physical barrier to the ingress of airborne irritants and plays an active role in the airways immune response, reacting to a range of environmental stimuli to enable interaction with immune and inflammatory cells. It is well established that mucosal damage and epithelial cell sheddin...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract::Anaphylaxis is a growing paediatric clinical emergency that is difficult to diagnose because a consensus definition was lacking until recently. Many European countries have no specific guidelines for anaphylaxis. This position paper prepared by the EAACI Taskforce on Anaphylaxis in Children aims to provide practical g...
journal_title:Allergy
pub_type: 杂志文章,实务指引
doi:10.1111/j.1398-9995.2007.01421.x
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00153.x
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Eosinophilic airway inflammation is the hallmark of asthma, but it has also been reported in other conditions such as allergic rhinitis. We have tested whether the analysis of cells and chemicals in sputum can distinguish between patients with mild allergic asthma, those with allergic rhinitis, and healthy c...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00312.x
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13725
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent asthma and allergic disease is conflicting. We examined whether following recommended breastfeeding guidelines alters the long-term risks o...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12833
更新日期:2016-05-01 00:00:00
abstract::The effect of intensive plasma separation performed eight times within 5 weeks in four patients with atopic dermatitis, bronchial asthma and hyperimmunoglobulinaemia E was followed as regards clinical symptoms and changes in the concentrations of serum (S) IgE, S IgG, S IgA, S IgM, plasma complement C3 split products,...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1984.tb01950.x
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:The general understanding is that a blood sample for analysis of immunoglobulin (Ig) E antibodies to an allergen suspected to cause an anaphylaxis cannot be drawn until several weeks after the reaction. As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluat...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01498.x
更新日期:2007-11-01 00:00:00
abstract::The role of cytokines in the accumulation of eosinophil granulocytes in inflamed tissue has been studied extensively during recent years, and these molecules have been found to participate throughout the whole process of eosinophil recruitment. Haematopoietic cytokines such as IL-3, IL-5 and GM-CSF stimulate the proli...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2004.00469.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). AIM OF THE STUDY:To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.01937.x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.2008.01627.x
更新日期:2008-04-01 00:00:00