Abstract:
BACKGROUND:Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). AIM OF THE STUDY:To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. METHODS:Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Moreover, challenges were performed with mustard oil (allylisothiocyanate) and cinnamaldehyde as well as menthol, activators of TRPA1 and TRPM8, respectively. Nasal symptoms were monitored after each challenge and compared with symptoms reported following corresponding sham challenges. Symptoms recorded after challenge prior to pollen season were also compared with challenge-induced symptoms during pollen season. RESULTS:The TRPV1, TRPA1 and TRPM8-activators produced sensory symptoms dominated by pain and smart. During seasonal allergen exposure, but not prior to season, TRPV1-activators also induced itch. Furthermore, the seasonal challenge to the TRPV1-activator olvanil was associated with rhinorrhoea. CONCLUSION:Patients with allergic rhinitis feature an increased itch response to TRPV1 stimulation at seasonal allergen exposure. We suggest that this reflects part of the hyperresponsiveness that characterizes on-going allergic rhinitis. Intervention with the TRPV1-signalling pathway may offer potential treatments of this condition.
journal_name
Allergyjournal_title
Allergyauthors
Alenmyr L,Högestätt ED,Zygmunt PM,Greiff Ldoi
10.1111/j.1398-9995.2009.01937.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
807-10issue
5eissn
0105-4538issn
1398-9995pii
ALL1937journal_volume
64pub_type
杂志文章相关文献
ALLERGY文献大全abstract::Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, p...
journal_title:Allergy
pub_type: 评论,社论
doi:10.1111/j.1398-9995.2008.01676.x
更新日期:2008-07-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) occurs in up to one-third of the adult US population. Most affected individuals are either unaware of their condition or do not seek medical help, relying on nonprescription acid suppressants and antacids for relief. GERD, a common disorder of infancy, old age, and pregnancy, is ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1999.00093.x
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Partial mattress encasing was found to be effective in reducing exposure to mite allergen in our previous investigation. We aimed to compare the short-term efficacy of partial and complete mattress encasing and to study mite-allergen levels within these mattresses. METHODS:Thirty-one mattresses with high mi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00060.x
更新日期:1999-07-01 00:00:00
abstract::Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12240
更新日期:2013-11-01 00:00:00
abstract::We observed two cases of maculopapular eruption occurring 12-72 h after the administration of aminocaproic acid (ACA). Patch tests performed with ACA were positive. Clinical and allergologic patterns suggest the type IV mechanism of hypersensitivity. We present what we believe are the first two cases described of hype...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb01217.x
更新日期:1995-09-01 00:00:00
abstract::Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted pap...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13329
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to investigate whether uncontrolled asthma was associated with healthcare outcomes among Latin American patients with asthma. We used data from 2168 patients with asthma who participated in the 2011 Latin America Asthma Insights and Management (AIM) survey. Using Global Initiative for Ast...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12237
更新日期:2013-11-01 00:00:00
abstract::A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb02661.x
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Two-flow cytometry methods for quantification of degranulated basophil after allergen-specific activation were discussed. The methods are discerned by used membrane receptors--FcepsilonRI or IL-3Ralpha Our goal was to evaluate the diagnostic potential of the methods and to correlate them to allergen-specific...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01087.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Immunoglobulin (Ig) A represents a first-line defence mechanism in the airways, but little is known regarding its implication in upper airway disorders. This study aimed to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic upper airway disea...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12274
更新日期:2013-12-01 00:00:00
abstract::The bronchial epithelium acts as a physical barrier to the ingress of airborne irritants and plays an active role in the airways immune response, reacting to a range of environmental stimuli to enable interaction with immune and inflammatory cells. It is well established that mucosal damage and epithelial cell sheddin...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high-affinity IgE receptor (FcεRI) and the related basophil function have a role in the induction of short-term VIT protection. METHODS:We included...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12044
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Anaphylaxis is an acute, potentially fatal, multi-organ system, allergic reaction caused by the release of chemical mediators from mast cells and basophils. Uncertainty exists around epidemiological measures of incidence and prevalence, risk factors, risk of recurrence, and death due to anaphylaxis. This sys...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12272
更新日期:2013-11-01 00:00:00
abstract::We performed immunoblotting experiments to determine specific IgE and IgG subclass responses to Candida albicans antigens in allergic bronchopulmonary aspergillosis (ABPA) patients. This is a first report describing C. albicans antigens recognized by serum IgE and IgG subclasses of ABPA patients sensitized to that yea...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb01018.x
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:In cross-sectional clinical studies, rhinitis has been shown to be strongly associated with co-existing chronic cough. However, to date, this association has been poorly delineated from a prospective and epidemiological standpoint. METHODS:We used data from the 'Pisa Prospective Study', a population-based l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00717.x
更新日期:2005-03-01 00:00:00
abstract::The aim of biological standardization (BS) is to equilibrate the activity (potency) of allergen extracts from different source materials. This was done by performing skin prick tests (SPT) on patients who were sensitive to one of the following 10 allergens: Birch, alder, hazel, timothy, rye grass, velvet grass, cultiv...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.1987.tb02368.x
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Histamine plays an important role in allergic inflammation. Histamine levels are regulated by histamine N-methyltransferase (HNMT). OBJECTIVE:To investigate the functional variability of HNMT gene in relation to genetic polymorphisms in patients with aspirin intolerant chronic urticaria (AICU). METHODS:Two...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01795.x
更新日期:2009-02-01 00:00:00
abstract::Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb01910.x
更新日期:1982-05-01 00:00:00
abstract::MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12880
更新日期:2016-11-01 00:00:00
abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs in nonimmunocompromised patients and belongs to the hypersensitivity disorders induced by Aspergillus. Genetic factors and activation of bronchial epithelial cells in asthma or cystic fibrosis are responsible for the development of a CD(4)+Th2 lymphocyte activation...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2005.00887.x
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:The presence of anti-FcepsilonRI and anti-IgE autoantibodies in a subset of patients with chronic urticaria suggests their aetiopathogenetic role. In clinical practice, the presence of these antibodies is usually considered when the autologous serum skin test (ASST) is positive. AIMS:To evaluate if the posi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00673.x
更新日期:2005-02-01 00:00:00
abstract::The present study was designed to investigate the effects of immunotherapy (IT) with an extract of Dermatophagoides pteronyssinus (Alergo-Merck Depot) during a 27-month period in patients with allergic asthma to house-dust mites. We included 11 patients (mean age 18 years) treated with a combination of IT and inhaled ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1996.tb04599.x
更新日期:1996-04-01 00:00:00
abstract::Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01336.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The prevalence of allergic rhinoconjunctivitis has increased significantly over the past decades with grass pollen being a common trigger. The impact of allergy on patient's quality of life is substantial. AIM:To investigate the sustained effect on quality of life during the grass pollen season 1 year after...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2009.02238.x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, alpha1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase i...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00938.x
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00153.x
更新日期:2003-06-01 00:00:00
abstract::The scarce data published on mite sensitization and mite-allergen levels in Norway indicate that the mites may not be of the same importance in allergic disease in Norway as in countries such as the UK and the rest of Europe. The problem also involves the low allergen levels and small amounts of dust collected for all...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1998.tb04999.x
更新日期:1998-01-01 00:00:00
abstract::Occupational respiratory allergy to green coffee beans in coffee roastery workers is well established. I now report on a 50-year-old female atopic patient sensitized to the coffee plant used for indoor decoration. The symptoms were rhinitis and conjunctivitis on exposure to the plant. Investigation showed a positive s...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00793.x
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses and is frequently divided into polypoid CRS (CRSwNP) and nonpolypoid CRS (CRSsNP). However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the s...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02706.x
更新日期:2012-01-01 00:00:00
abstract::Tiaramide hydrochloride (THC) is a new basic, non-steroidal, anti-flammatory drug. Its anti-anaphylactic action has been investigated using rat mast cells. It was found that THC exerts a strong inhibitory action on antigen-induced and compound 48/80-induced histamine release from rat peritoneal mast cells in a fluorom...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1978.tb01512.x
更新日期:1978-04-01 00:00:00