Allergic bronchopulmonary aspergillosis.

Abstract:

:Allergic bronchopulmonary aspergillosis (ABPA) occurs in nonimmunocompromised patients and belongs to the hypersensitivity disorders induced by Aspergillus. Genetic factors and activation of bronchial epithelial cells in asthma or cystic fibrosis are responsible for the development of a CD(4)+Th2 lymphocyte activation and IgE, IgG and IgA-AF antibodies production. The diagnosis of ABPA is based on the presence of a combination of clinical, biological and radiological criteria. The severity of the disease is related to corticosteroid-dependant asthma or/and diffuse bronchiectasis with fibrosis. The treatment is based on oral corticosteroids for 6-8 weeks at acute phase or exacerbation and itraconazole is now recommended and validated at a dose of 200 mg/day for a duration of 16 weeks.

journal_name

Allergy

journal_title

Allergy

authors

Tillie-Leblond I,Tonnel AB

doi

10.1111/j.1398-9995.2005.00887.x

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

1004-13

issue

8

eissn

0105-4538

issn

1398-9995

pii

ALL887

journal_volume

60

pub_type

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