Fexofenadine reduces nasal congestion in perennial allergic rhinitis.

Abstract:

BACKGROUND:Nasal congestion is the predominant symptom in perennial allergic rhinitis (PAR), and it seems to be mainly related to the late-phase inflammatory events. The present pilot study aimed to evaluate the therapeutic effect exerted by fexofenadine in patients with PAR due to mite allergy. METHODS:This study was a parallel, double-blind, randomized, three-arm (1:1:1), placebo-controlled study. Thirty-one subjects with PAR were enrolled and received double-blind medication: fexofenadine 120 or 180 mg, or placebo, once a day for 28 days. RESULTS:The total symptom score was reduced by fexofenadine (both dosages) at V2 (P=0.007), whereas placebo did not modify it. Nasal congestion decreased after 1 week of treatment with fexofenadine 120 (P=0.027) and 180 (P=0.01), but not with placebo (P=NS). At V3, fexofenadine (both dosages) significantly reduced nasal congestion (P=0.011 and P=0.007, respectively), by placebo did not show any significant effect. CONCLUSIONS:This pilot study represents the first evidence of the efficacy of fexofenadine in PAR, and also the control of the nasal congestion. We suggest performing larger trials to confirm these preliminary findings.

journal_name

Allergy

journal_title

Allergy

authors

Ciprandi G,Cosentino C,Milanese M,Mondino C,Canonica GW

doi

10.1034/j.1398-9995.2001.00191.x

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1068-70

issue

11

eissn

0105-4538

issn

1398-9995

pii

191

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验

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