Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.

Abstract:

:Six children and six adults were given a single dose of a sustained release theophylline preparation (Nuelin Retard) after an overnight fast and later after a standardized breakfast. Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food. Under steady state treatment the fluctuations in the serum levels of theophylline were small when the tablets were taken after meals twice a day showing that this dose regimen was sufficient. No characteristic absorption or elimination phases were seen during the steady state dose interval, and the time to peak serum theophylline level showed great variation. Serum theophylline control about 4 h after fasting intake of the tablet is recommended.

journal_name

Allergy

journal_title

Allergy

authors

Pedersen S,Moeller-Petersen J

doi

10.1111/j.1398-9995.1982.tb02336.x

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

531-4

issue

7

eissn

0105-4538

issn

1398-9995

journal_volume

37

pub_type

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