Abstract:
BACKGROUND:Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY:To investigate the immunological consequence of IgE withdrawal, we studied the influence of omalizumab on stimulated IgE-release of cultured peripheral blood mononuclear cells (PBMC) and on the relative number of lymphocytes in the peripheral blood (cellular immune status) in patients with allergic asthma. METHODS:Nineteen patients were enrolled and received omalizumab at a dose of at least 0.016 mg/kg/IgE (IU/ml) every 4 weeks. PBMC were isolated from peripheral blood. Cells were cultured and stimulated with IL-4 (5 ng/ml) and CD40 ligand (1 microg/ml) for 10 days. IgE release was detected in cell culture supernatants by enzyme-linked immunosorbent assay (ELISA). Cellular immune status was investigated by fluorescence-activated cell sorting. RESULTS:Omalizumab treatment induced significant inhibition of stimulated IgE release (median 1.38-0 ng/ml vs. 1.64-2.0 ng/ml in placebo group, P<0.05). B-lymphocyte counts were also significantly lower in the omalizumab group compared with placebo after 12 weeks of treatment (median 18.2-15.6% lymphocytes vs 12.7-13.7% lymphocytes after placebo, P<0.01). There were no significant differences in the other lymphocyte subpopulations between the groups. CONCLUSIONS:These findings provide evidence of immunological influences of omalizumab treatment, leading to a downregulation of IgE secretion and decrease of lymphocyte subpopulations (B-cells) indicating their anti-inflammatory potency.
journal_name
Allergyjournal_title
Allergyauthors
Hanf G,Brachmann I,Kleine-Tebbe J,Seybold J,Kunkel G,Suttorp N,Noga Odoi
10.1111/j.1398-9995.2006.01180.xsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
1141-4issue
9eissn
0105-4538issn
1398-9995pii
ALL1180journal_volume
61pub_type
杂志文章相关文献
ALLERGY文献大全abstract::Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01336.x
更新日期:2007-03-01 00:00:00
abstract::In a study of 770 patients with allergic rhinitis, anamnestic data were collected by means of a questionnaire. 484 (63%) of the patients were women and 286 (37%) men. 45.5% of the patients had perennial symptoms, 33.5% had seasonal symptoms only, and 21% had predominantly seasonal but also some perennial symptoms. Mor...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb02317.x
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Because little is known about the effects of asthma and asthma therapy on lipid and protein metabolism, we have investigated the characteristics of diet and plasma/serum levels of fat and protein in a group of asthma patients with various degrees of severity. METHODS:A case-control study was carried out on ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00024.x
更新日期:1999-06-01 00:00:00
abstract::CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2011.02576.x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Fluorescence-labeled MHC class II/peptide tetramer complexes are considered as optimal tools to characterize allergen-specific CD4(+) T cells, but this technique is restricted to frequently expressed HLA class II molecules and knowledge of immunodominant epitopes. In contrast, allergen-stimulated proliferati...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12524
更新日期:2015-01-01 00:00:00
abstract::Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12240
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Several epidemiology studies have found an increase in the major cockroach allergen Bla g 2 with reported pesticide use. AIMS OF THE STUDY:Our aim was to investigate the effect on the excretion of Bla g 1 and Bla g 2 allergens by cockroaches exposed to sub-lethal doses of the pesticides, boric acid and hydr...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00814.x
更新日期:2005-07-01 00:00:00
abstract::The role of cytokines in the accumulation of eosinophil granulocytes in inflamed tissue has been studied extensively during recent years, and these molecules have been found to participate throughout the whole process of eosinophil recruitment. Haematopoietic cytokines such as IL-3, IL-5 and GM-CSF stimulate the proli...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2004.00469.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00153.x
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q(2)oL) and to provide reference assessments of QoL. METHODS:The...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01920.x
更新日期:2009-06-01 00:00:00
abstract::A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot t...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1981.tb01861.x
更新日期:1981-10-01 00:00:00
abstract::Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including geneti...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12126
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Exposure to acrylates may give rise to rhinitis and asthma in both industrial and domestic environments. The mechanisms underlying these respiratory conditions caused by acrylates remain largely unknown. METHODS:We studied two assembly operators exposed to cyanoacrylate glue who developed rhinitis and asthm...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056005446.x
更新日期:2001-05-01 00:00:00
abstract::A crossed radioimmunoelectrophoretic (CRIE) method for detection of human IgG subclass specificities against individual antigens is described. After crossed immunoelectrophoresis (CIE) of the antigens the immunoplates are incubated with serum, washed and incubated with mouse monoclonal anti-human IgG-subclass antibodi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1984.tb01983.x
更新日期:1984-11-01 00:00:00
abstract::The eosinophilic granulocyte is commonly associated with allergic inflammation. Although blood eosinophilia frequently accompanies atopic dermatitis, accumulation of tissue eosinophils is not prominent. Recent studies have elucidated the structure, content, and activities of the eosinophil. In addition, immunofluoresc...
journal_title:Allergy
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01342.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Class I chitinase in natural rubber latex (NRL) has been assumed to be an important allergen, especially concerning its cross-reactivity with fruits like avocado and banana. OBJECTIVES:The present study aimed to produce a recombinant latex class I chitinase from Hevea brasiliensis leaves and to study its im...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00058.x
更新日期:2003-03-01 00:00:00
abstract::Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent in...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14624
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:The prevalence of self-reported symptoms of allergic rhinitis is increasing in many countries, but the reasons for this trend are not well understood. Data from a 6-year follow-up study of a population sample of children and adolescents (n=408), aged 7-17 years at enrolment in 1986, were analyzed to investig...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00630.x
更新日期:2000-11-01 00:00:00
abstract::Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods and management of acute allergic reactions with antihistamines an...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14116
更新日期:2020-06-01 00:00:00
abstract::The clinical effects in asthma of corticosteroids can be ascribed to their strong anti-inflammatory action. The pathophysiology of asthma is complex. A diversity of mediators and interactions between mediators and between mediators and various cell types enhances and maintains the inflammatory process in the airways r...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1988.tb00908.x
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Abnormalities, including bronchiectasis, that are detectable on high-resolution computed tomography (HRCT) have been associated with severe asthma. Bronchiectasis is associated with the diagnosis of allergic bronchopulmonary aspergillosis (ABPA), which also occurs in patients with severe asthma. We sought to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02542.x
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Immunoglobulin E (IgE)-mediated allergy belongs to common chronic disorders resulting from an interaction between both genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31.1, a region that is linked to asthma and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00271.x
更新日期:2003-10-01 00:00:00
abstract::This study delineates the prevalence of reactions to condoms among latex-allergic patients seen in allergy consultation services since 1987. Questionnaires were mailed to 374 patients previously found to have clinically significant allergy to latex. Of these, only 238 completed the questionnaire. The respondents we...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03827.x
更新日期:1998-11-01 00:00:00
abstract::The effect of interleukin-3 (IL-3) on histamine release from cord and adult blood basophils were evaluated. Leukocyte suspensions, obtained from adult patients with respiratory allergy (n = 15), normal adult subjects (n = 15), and neonates with (n = 15) and without (n = 19) atopic disposition, were stimulated with ant...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb02419.x
更新日期:1997-10-01 00:00:00
abstract::The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulat...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1985.tb04157.x
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Birch pollen allergies are frequently associated with adverse reactions to various fruits, nuts, or vegetables, described as pollen-food syndrome (PFS) and caused by cross-reactive IgE antibodies primarily directed against Bet v 1. Specific immunotherapy (SIT) represents an effective treatment for inhalant a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12306
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Food allergy in children can be life-threatening. Component-resolved diagnostics approach to food anaphylaxis is rarely assessed in children. The aim of the study was to identify the food allergen components as the triggers responsible for severe anaphylaxis, with regard to characteristics and associated ris...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13810
更新日期:2019-10-01 00:00:00
abstract::Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb01910.x
更新日期:1982-05-01 00:00:00
abstract::The presence of viable mold propagules in house dust was investigated by 10 different analytic methods, in order to determine to what extent different results are obtained when different analytic methods are used. Moreover, the value of this measurement as an estimator of the potential exposure to fungi in epidemiolog...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb01125.x
更新日期:1994-08-01 00:00:00