Advances and novel developments in environmental influences on the development of atopic diseases.


:Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent indoors, use of antibiotics, and consumption of processed foods and decreased contact with farm animals and pets, which limit exposure to environmental allergens, infectious parasitic worms, and microbes. The lack of exposure to these factors is thought to prevent proper education and training of the immune system. Increased industrialization and urbanization have brought about increases in organic and inorganic pollutants. In addition, Caesarian birth, birth order, increased use of soaps and detergents, tobacco smoke exposure and psychosomatic factors are other factors that have been associated with increased rate of allergic diseases. Here, we review current knowledge on the environmental factors that have been shown to affect the development of allergic diseases and the recent developments in the field.






Alkotob SS,Cannedy C,Harter K,Movassagh H,Paudel B,Prunicki M,Sampath V,Schikowski T,Smith E,Zhao Q,Traidl-Hoffmann C,Nadeau KC




Has Abstract


2020-10-09 00:00:00








  • How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?: Report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop.

    abstract::Quantitative risk assessment (QRA) for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depen...


    pub_type: 杂志文章,评审


    authors: Dubois AEJ,Turner PJ,Hourihane J,Ballmer-Weber B,Beyer K,Chan CH,Gowland MH,O'Hagan S,Regent L,Remington B,Schnadt S,Stroheker T,Crevel RWR

    更新日期:2018-07-01 00:00:00

  • Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps.

    abstract:BACKGROUND:The role of myeloid and plasmacytoid dendritic cells and its consequences for the T(H)2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP(+)) should be detailed. METHODS:In 18 CRS patients without nasal polyps (CRSNP(-)), 35 CRSNP(+) patients and 22 patients with nasal structural abnormalities w...


    pub_type: 杂志文章


    authors: Kirsche H,Niederführ A,Deutschle T,Fuchs C,Riechelmann H

    更新日期:2010-01-01 00:00:00

  • Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel.

    abstract:OBJECTIVE:To determine the prevalence, importance, and the order of frequency of IgE-mediated food allergens among infants and young children in Israel. STUDY DESIGN AND PATIENTS:In a cross-sectional study, the prevalence of IgE-mediated food allergy was investigated in 9070 infants and young children (0-2 years) who ...


    pub_type: 杂志文章


    authors: Dalal I,Binson I,Reifen R,Amitai Z,Shohat T,Rahmani S,Levine A,Ballin A,Somekh E

    更新日期:2002-04-01 00:00:00

  • Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus-predominant subgroup.

    abstract:BACKGROUND:Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti-microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio....


    pub_type: 杂志文章


    authors: Diver S,Richardson M,Haldar K,Ghebre MA,Ramsheh MY,Bafadhel M,Desai D,Cohen ES,Newbold P,Rapley L,Rugman P,Pavord ID,May RD,Barer M,Brightling CE

    更新日期:2020-04-01 00:00:00

  • Impact of (bio)chemical and physical procedures on food allergen stability.

    abstract::A variety of methods have been used to attempt to decrease the allergenicity of food products, with highly variable success. Limited knowledge of allergen and epitope structures and the factors governing their stability may explain this, and the ensuing need for an empirical approach. A combined effort from a processi...


    pub_type: 杂志文章,评审


    authors: Soler-Rivas C,Wichers HJ

    更新日期:2001-01-01 00:00:00

  • Occupational type I allergy to Christmas cactus (Schlumbergera).

    abstract::The study aimed to determine whether occupational contact urticaria and symptoms of mucous membranes, reported by five workers in a cactus nursery, were due to IgE-mediated allergy to Schlumbergera cacti. The five persons had positive skin prick tests to the plants as is and positive histamine-release tests, and in th...


    pub_type: 杂志文章


    authors: Paulsen E,Skov PS,Bindslev-Jensen C,Voitenko V,Poulsen LK

    更新日期:1997-06-01 00:00:00

  • Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma.

    abstract::Although H1 antihistamine compounds (H1) are highly effective in the treatment of allergic rhinitis (AR), their role in the treatment of asthma is still controversial. Because a strong association between AR and bronchial hyperresponsiveness (BHR) has been reported, this study was designed to assess the effect of a ne...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Aubier M,Neukirch C,Peiffer C,Melac M

    更新日期:2001-01-01 00:00:00

  • Urban/rural differences in diet and atopy in South Africa.

    abstract:BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...


    pub_type: 临床试验,杂志文章


    authors: Hooper R,Calvert J,Thompson RL,Deetlefs ME,Burney P

    更新日期:2008-04-01 00:00:00

  • Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels.

    abstract:BACKGROUND:Intranasal noninhaled delivery of carbon dioxide (CO₂) is efficacious in the symptomatic treatment of seasonal allergic rhinitis. The goal of this study was to determine whether and how 100% CO₂ inhibits mast cell degranulation, thereby possibly contributing to the reduction of symptoms in seasonal allergic ...


    pub_type: 杂志文章


    authors: Strider JW,Masterson CG,Durham PL

    更新日期:2011-03-01 00:00:00

  • Plasma protein profiles in early asthmatic responses to inhalation allergen challenge.

    abstract::Although mediators, such as lipids, cytokines, and chemokines, are related to the appearance of an IPR, there has been no reliable indicator to predict conditions for the appearance of an IPR. In this study, we adopted a proteomic approach to investigate the pathogenesis at the level of the plasma proteins and to deve...


    pub_type: 杂志文章


    authors: Rhim T,Choi YS,Nam BY,Uh ST,Park JS,Kim YH,Paik YK,Park CS

    更新日期:2009-01-01 00:00:00

  • Markers for eosinophils and T-lymphocytes as predictors of late asthmatic response.

    abstract::Bronchial allergen challenge was performed on 12 allergic asthmatics during a stable phase of their disease. After resolution of the immediate bronchial response, fractional lung lavage was performed twice, two and 24 h post-challenge. The recovery of eosinophils, eosinophil cationic protein (ECP), eosinophil chemotac...


    pub_type: 杂志文章


    authors: Schmekel B,Venge P

    更新日期:1993-01-01 00:00:00

  • Cost-effectiveness of asthma control: an economic appraisal of the GOAL study.

    abstract:BACKGROUND:The Gaining Optimal Asthma ControL (GOAL) study has shown the superiority of a combination of salmeterol/fluticasone propionate (SFC) compared with fluticasone propionate alone (FP) in terms of improving guideline defined asthma control. METHODS:Clinical and economic data were taken from the GOAL study, sup...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Briggs AH,Bousquet J,Wallace MV,Busse WW,Clark TJ,Pedersen SE,Bateman ED,GOAL Investigators Group.

    更新日期:2006-05-01 00:00:00

  • Priming and inducing effects of interleukin-3 on histamine release from cord-blood basophils.

    abstract::The effect of interleukin-3 (IL-3) on histamine release from cord and adult blood basophils were evaluated. Leukocyte suspensions, obtained from adult patients with respiratory allergy (n = 15), normal adult subjects (n = 15), and neonates with (n = 15) and without (n = 19) atopic disposition, were stimulated with ant...


    pub_type: 杂志文章


    authors: Miadonna A,Salmaso C,Marco MP,Pugni L,Milazzo N,Tedeschi A,Marini A

    更新日期:1997-10-01 00:00:00

  • Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens.

    abstract:BACKGROUND:The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to...


    pub_type: 杂志文章


    authors: Klinglmayr E,Hauser M,Zimmermann F,Dissertori O,Lackner P,Wopfner N,Ferreira F,Wallner M

    更新日期:2009-04-01 00:00:00

  • Increased prevalence of latex-sensitization among children with chronic renal failure.

    abstract:BACKGROUND:Type-I-allergy to natural rubber latex (NRL) has been shown to be more prevalent among certain groups of patients. Children suffering from chronic renal failure (CRF) could be a suspected risk group because of their intense exposure to latex through catheters, gloves and anesthetic equipment during frequent ...


    pub_type: 杂志文章


    authors: Dehlink E,Prandstetter C,Eiwegger T,Putschögl B,Urbanek R,Szépfalusi Z

    更新日期:2004-07-01 00:00:00

  • Combined skin prick and patch testing enhances identification of peanut-allergic patients with atopic dermatitis.

    abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...


    pub_type: 杂志文章


    authors: Seidenari S,Giusti F,Bertoni L,Mantovani L

    更新日期:2003-06-01 00:00:00

  • Single-dose inhaled budesonide in subjects with chronic asthma.

    abstract::In 30 stable asthmatics, a comparison was made between the changes in pulmonary function (FEV1, FVC, PEF, MEF75, MEF50 and MEF25) hourly for 9 h after a single dose of inhaled budesonide 1,600 micrograms, and placebo. All subjects used inhaled steroids daily; this medication was, however, withheld 8 days prior to the ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Engel T,Dirksen A,Heinig JH,Nielsen NH,Weeke B,Johansson SA

    更新日期:1991-10-01 00:00:00

  • The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis.

    abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...


    pub_type: 杂志文章


    authors: Hu Y,Matsumoto Y,Dogru M,Okada N,Igarashi A,Fukagawa K,Tsubota K,Fujishima H

    更新日期:2007-08-01 00:00:00

  • Undernotification of anaphylaxis deaths in Brazil due to difficult coding under the ICD-10.

    abstract:BACKGROUND:Undernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-spe...


    pub_type: 杂志文章


    authors: Tanno LK,Ganem F,Demoly P,Toscano CM,Bierrenbach AL

    更新日期:2012-06-01 00:00:00

  • Results of wearing test with two different latex gloves with and without the use of skin-protection cream.

    abstract::A total of 109 subjects reporting symptoms indicating type I hypersensitivity reactions to natural rubber latex (NRL) gloves was included in this study, and 66 of them had latex-specific IgE antibodies. They underwent provocation tests by wearing two types of NRL gloves with high (n=103) and low (n=75) allergen conten...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baur X,Chen Z,Allmers H,Raulf-Heimsoth M

    更新日期:1998-04-01 00:00:00

  • Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts.

    abstract:BACKGROUND:Although atopic sensitization is one of the strongest risk factors for asthma, its relationship with asthma is poorly understood. We hypothesize that 'atopy' encompasses multiple sub-phenotypes that relate to asthma in different ways. METHODS:In two population-based birth cohorts (Manchester and Isle of Wig...


    pub_type: 杂志文章


    authors: Lazic N,Roberts G,Custovic A,Belgrave D,Bishop CM,Winn J,Curtin JA,Hasan Arshad S,Simpson A

    更新日期:2013-06-01 00:00:00

  • Systemic contact dermatitis to copper-containing IUD.

    abstract::Although copper sulfate can cause systemic contact dermatitis, few such cases have been recorded among copper-releasing IUD users. Reported in this paper is a case of endometritis and urticaria-angioedema syndrome in a 32-year-old user of a copper IUD. Widespread urticaria, as well as angioedema of the eyelids and t...


    pub_type: 杂志文章


    authors: Purello D'Ambrosio F,Ricciardi L,Isola S,Gangemi S,Cilia M,Levanti C,Marcazzò A

    更新日期:1996-09-01 00:00:00

  • Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines.

    abstract:BACKGROUND:The worldwide increasing incidence of allergic diseases requires the development of new, efficient vaccination strategies, the only curative treatment with a long-lasting effect. Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time. METHODS:We engineered m...


    pub_type: 杂志文章


    authors: Crameri R,Flückiger S,Daigle I,Kündig T,Rhyner C

    更新日期:2007-02-01 00:00:00

  • Double-blind, placebo-controlled food challenge with apple.

    abstract::The aim of the study was to develop and evaluate different methods of double-blind, placebo-controlled food challenge (DBPCFC) with apple. Three different DBPCFC models were evaluated: fresh apple juice, freshly grated apple, and freeze-dried apple powder. All challenges were performed outside the pollen season and to...


    pub_type: 临床试验,杂志文章


    authors: Skamstrup Hansen K,Vestergaard H,Stahl Skov P,Søndergaard Khinchi M,Vieths S,Poulsen LK,Bindslev-Jensen C

    更新日期:2001-02-01 00:00:00

  • A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-QoL).

    abstract:BACKGROUND:Health-related quality of Life in patients with chronic urticaria is evaluated by mean of generic instruments or questionnaire designed for skin diseases. No disease-specific tool is now available for the assessment of chronic urticaria impact from patients' viewpoint. OBJECTIVE:The aim of our study is to d...


    pub_type: 杂志文章


    authors: Baiardini I,Pasquali M,Braido F,Fumagalli F,Guerra L,Compalati E,Braga M,Lombardi C,Fassio O,Canonica GW

    更新日期:2005-08-01 00:00:00

  • Impairment of T helper and T regulatory cell responses at birth.

    abstract:BACKGROUND:There is strong evidence that reduced exposures to microbial compounds triggering innate immune responses early in life are critical for the development of allergic illnesses. The underlying mechanisms remain unknown, but will include T-cell responses either along T helper type 1 (Th1)/Th2 pathways or via T ...


    pub_type: 杂志文章


    authors: Schaub B,Liu J,Schleich I,Höppler S,Sattler C,von Mutius E

    更新日期:2008-11-01 00:00:00

  • Natural evolution of skin-test sensitivity in patients with IgE-mediated hypersensitivity to cephalosporins.

    abstract::There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospe...


    pub_type: 杂志文章


    authors: Romano A,Gaeta F,Valluzzi RL,Zaffiro A,Caruso C,Quaratino D

    更新日期:2014-06-01 00:00:00

  • Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation.

    abstract:BACKGROUND:Exposure to environmental endocrine-disrupting chemicals (EDCs) is associated with allergy, chronic inflammation, and immunodeficiency. Phthalates, the common EDCs used in plastic industry, may act as adjuvants to disrupt immune system and enhance allergy. Plasmacytoid DCs (pDCs) are predominant cells secret...


    pub_type: 杂志文章


    authors: Kuo CH,Hsieh CC,Kuo HF,Huang MY,Yang SN,Chen LC,Huang SK,Hung CH

    更新日期:2013-07-01 00:00:00

  • Atopy and asthma in rural Poland: a paradigm for the emergence of childhood respiratory allergies in Europe.

    abstract:BACKGROUND:We hypothesized that, in south-west Poland, a 'rural' protective effect on atopy and respiratory allergies would be most pronounced among children but that at all ages would be stronger among those with a rural background. METHODS:A cross-sectional survey of the inhabitants (age >5 years, n = 1657) of Sobot...


    pub_type: 杂志文章


    authors: Sozanska B,Macneill SJ,Kajderowicz-Kowalik M,Danielewicz H,Wheatley M,Newman Taylor AJ,Boznanski A,Cullinan P

    更新日期:2007-04-01 00:00:00

  • Allergy to jackfruit: a novel example of Bet v 1-related food allergy.

    abstract:BACKGROUND:Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens. OBJECTIVE:Establish whether jackfruit allergy is linked to birchpollen allergy. METHODS:Two jackfruit allergic patients and five patients with...


    pub_type: 杂志文章


    authors: Bolhaar ST,Ree R,Bruijnzeel-Koomen CA,Knulst AC,Zuidmeer L

    更新日期:2004-11-01 00:00:00