Safety of rush insect venom immunotherapy. The results of a retrospective study in 178 patients.

Abstract:

BACKGROUND:Venom immunotherapy (VIT) is regarded as an established and efficient treatment of Hymenoptera venom allergy. Different frequencies of side-effects have been reported in the literature, depending on the hyposensitization regimen (conventional outpatient programme, rush immunotherapy, ultra rush immunotherapy) and the venom preparation. Aim of this study was to evaluate safety and tolerance of rush VIT in patients treated with a 7-day protocol in our department. METHODS:VIT protocols of 178 patients treated at the Department of Dermatology and Allergy of the University of Bonn were analysed retrospectively. All patients had been treated with a standardized venom preparations (ALK-SQ). We used a modified VIT-protocol with a 2-day break to reduce systemic side-effects. RESULTS:During the course of VIT in 15 patients (8.4%) systemic reactions grade I (Mueller scale) were observed, in seven (3.9%) grade II, in six (3.4%) grade III and in four (2.2%) grade IV. A total of 146 patients (82.1%) had no or only local reactions. CONCLUSIONS:The rate of systemic adverse reactions Mueller Grade I-IV of 17.9% of the 'Bonn rush VIT protocol' appears to be relatively low compared with the data in the literature.

journal_name

Allergy

journal_title

Allergy

authors

Wenzel J,Meissner-Kraemer M,Bauer R,Bieber T,Gerdsen R

doi

10.1034/j.1398-9995.2003.00268.x

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1176-9

issue

11

eissn

0105-4538

issn

1398-9995

pii

268

journal_volume

58

pub_type

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