Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine.

Abstract:

:Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H1 and H2 antihistamines in six of 12 patients with RA in active phase, whereas four showed definite deterioration.

journal_name

Allergy

journal_title

Allergy

authors

Permin H,Skov PS,Norn S,Geisler A,Klysner R,Andersen V,Wiik A,Manthorpe R,Nielsen H,Petersen J

doi

10.1111/j.1398-9995.1981.tb01852.x

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

435-6

issue

6

eissn

0105-4538

issn

1398-9995

journal_volume

36

pub_type

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