Markers of autoreactivity, coagulation and angiogenesis in patients with nonallergic asthma.

Abstract:

BACKGROUND:Patients with nonallergic asthma frequently show autoreactivity as do subjects with chronic urticaria (CU). Activation of the coagulation cascade and hyper-expression of vascular endothelial growth factor (VEGF) were recently found in CU, and there is sparse evidence that the same may occur in asthma. OBJECTIVE:To investigate autoreactivity, activation of the coagulation cascade, and expression of VEGF in patients with nonallergic asthma. METHODS:Twenty-one adults with nonallergic asthma underwent autologous plasma skin test (APST) and the measurement of plasma levels of the prothrombin fragment F1+2, D-dimer, VEGF, and the inflammatory marker C-reactive protein (CRP). Twenty-one healthy sex- and age-matched subjects served as normal controls. RESULTS:The APST scored positive in 19 of 21 (90%) patients vs 0 controls. Mean fragment F1+2 plasma levels were significantly higher in patients with asthma (267 ± 243 pM) than in controls (150 ± 51 pM; P = 0.0001). Similarly, plasma levels of both D-dimer and VEGF were significantly higher in patients than in controls (D-dimer: 2364 ± 1467 vs 1301 ± 525 pM; P = 0.0001; VEGF: 1721 ± 2566 vs 76 ± 375 fM; P = 0.0001). A trend toward increased levels of F1+2, D-dimer, VEGF, and CRP was found in patients with a more severe disease according to GINA classification. CONCLUSION:Nonallergic asthma is characterized by autoreactivity as well as increased coagulation and angiogenesis markers, which are known to enhance vascular permeability. The presence of circulating vasoactive factors may be relevant to understand the disease pathophysiology and to detect novel therapeutic strategies in nonallergic asthma.

journal_name

Allergy

journal_title

Allergy

authors

Asero R,Tedeschi A,Cugno M

doi

10.1111/j.1398-9995.2011.02668.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1339-44

issue

10

eissn

0105-4538

issn

1398-9995

journal_volume

66

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Oral disodium cromoglycate treatment of atopic dermatitis.

    abstract::Fourteen adults and 10 children with active atopic dermatitis entered this double blind cross-over study of oral disodium cromoglycate (DSCG) (adults 200 mg qid, children 100 mg qid) compared with placebo. Oral DSCG and placebo were given for 6 weeks in random order. According to the investigators' assessments of ecze...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1983.tb01601.x

    authors: Lindskov R,Knudsen L

    更新日期:1983-04-01 00:00:00

  • Allergic rhinitis: not purely a histamine-related disease.

    abstract::Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1034/j.1398-9995.2000.00802.x

    authors: Howarth PH,Salagean M,Dokic D

    更新日期:2000-01-01 00:00:00

  • Cost-effectiveness of asthma control: an economic appraisal of the GOAL study.

    abstract:BACKGROUND:The Gaining Optimal Asthma ControL (GOAL) study has shown the superiority of a combination of salmeterol/fluticasone propionate (SFC) compared with fluticasone propionate alone (FP) in terms of improving guideline defined asthma control. METHODS:Clinical and economic data were taken from the GOAL study, sup...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2006.01038.x

    authors: Briggs AH,Bousquet J,Wallace MV,Busse WW,Clark TJ,Pedersen SE,Bateman ED,GOAL Investigators Group.

    更新日期:2006-05-01 00:00:00

  • Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens.

    abstract:BACKGROUND:Involvement of paranasal sinuses has been suggested in allergic rhinitis but not clearly demonstrated. AIMS:To investigate the relationship between intermittent allergic rhinitis and computerized tomography (CT). METHODS:Twenty patients with intermittent rhinitis and sensitized to cypress pollens underwent...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00509.x

    authors: Piette V,Bousquet C,Kvedariene V,Dhivert-Donnadieu H,Crampette L,Senac JP,Bousquet J,Demoly P

    更新日期:2004-08-01 00:00:00

  • Four-year stability of Der p I in house dust under simulated domestic conditions in vitro.

    abstract::For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00813.x

    authors: Kort HS,Kniest FM

    更新日期:1994-02-01 00:00:00

  • Placebo-controlled challenges with perfume in patients with asthma-like symptoms.

    abstract::A group of nine patients with respiratory symptoms after nonspecific irritating stimuli, but without any IgE-mediated allergy or demonstrable bronchial obstruction, were referred to the asthma/allergy outpatient department for evaluation of suspected asthma. In order to find a provocation model and objectively assess ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1996.tb04644.x

    authors: Millqvist E,Löwhagen O

    更新日期:1996-06-01 00:00:00

  • Clinical evaluation of in vitro leukocyte histamine release in allergy to muscle relaxant drugs.

    abstract::We have evaluated the in vitro leukocyte histamine release tests for the diagnosis of allergy to muscle relaxant drugs in 40 patients (Group A) and a control group of 44 subjects with negative leukocyte histamine release (Group B). Non-IgE dependent histamine release, expressed as a percentage of the total blood hista...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb00667.x

    authors: Mata E,Guéant JL,Moneret-Vautrin DA,Bermejo N,Gérard P,Nicolas JP,Laxenaire MC

    更新日期:1992-10-01 00:00:00

  • Comparative evaluation between two immunoenzymatic techniques (FAST and Phadezym) and the Phadebas RAST in food allergy.

    abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb00466.x

    authors: Moneret-Vautrin DA,Gueant JL,Abdel-Ghani A,Maria Y,Nicolas JP

    更新日期:1990-02-01 00:00:00

  • The role of hen's egg-specific IgE, IgG and IgG4 in the diagnostic procedure of hen's egg allergy.

    abstract:BACKGROUND:Hen's egg (HE) allergy is a common disease in childhood. HE-specific serum IgE has been correlated with the outcome of oral food challenge tests, and diagnostic decision points have been described as helpful but still not sufficient to reduce the requirement for oral food challenges. The aim of the study was...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02429.x

    authors: Ahrens B,Lopes de Oliveira LC,Schulz G,Borres MP,Niggemann B,Wahn U,Beyer K

    更新日期:2010-12-01 00:00:00

  • CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis.

    abstract:BACKGROUND:The contribution of B-cell subsets and T-B cell interaction to the pathogenesis of allergic rhinitis (AR) and mechanisms of allergen immunotherapy (AIT) remain poorly understood. This study aimed to outline circulating B-cell signature, the underlying mechanism, and its association with clinical response to ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14288

    authors: Yao Y,Wang N,Chen CL,Pan L,Wang ZC,Yunis J,Chen ZA,Zhang Y,Hu ST,Xu XY,Zhu RF,Yu D,Liu Z

    更新日期:2020-10-01 00:00:00

  • Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics.

    abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01342.x

    authors: Kay AB,Ali FR,Heaney LG,Benyahia F,Soh CP,Renz H,Lee TH,Larché M

    更新日期:2007-05-01 00:00:00

  • Aspirin tolerance induced in aspirin-sensitive asthmatics.

    abstract::Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patien...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1984.tb02621.x

    authors: Kowalski ML,Grzelewska-Rzymowska I,Rozniecki J,Szmidt M

    更新日期:1984-04-01 00:00:00

  • Arizona cypress (Cupressus arizonica) pollen allergens. Identification of cross-reactive periodate-resistant and -sensitive epitopes with monoclonal antibodies.

    abstract::Species of the Cupressaceae family are a worldwide cause of respiratory allergies. We used monoclonal antibodies (mAbs) to investigate the presence and the nature of cross-reacting epitopes shared by various components within Cupressus arizonica pollen extract (CaE) or by CaE and pollen extract from C. sempervirens (C...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03934.x

    authors: Barletta B,Tinghino R,Corinti S,Afferni C,Iacovacci P,Mari A,Pini C,Di Felice G

    更新日期:1998-06-01 00:00:00

  • Inhibition of IgE binding to cross-reactive carbohydrate determinants enhances diagnostic selectivity.

    abstract:BACKGROUND:Allergy diagnosis by determination of allergen-specific IgE is complicated by clinically irrelevant IgE, of which the most prominent example is IgE against cross-reactive carbohydrate determinants (CCDs) that occur on allergens from plants and insects. Therefore, CCDs cause numerous false-positive results. I...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12229

    authors: Holzweber F,Svehla E,Fellner W,Dalik T,Stubler S,Hemmer W,Altmann F

    更新日期:2013-10-01 00:00:00

  • Understanding the challenges faced by adolescents and young adults with allergic conditions: A systematic review.

    abstract:BACKGROUND:Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. METHODS:A systematic literature search was under...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14258

    authors: Vazquez-Ortiz M,Angier E,Blumchen K,Comberiati P,Duca B,DunnGalvin A,Gore C,Hox V,Jensen B,Pite H,Santos AF,Sanchez S,Alviani C,Garriga-Baraut T,Knibb R,Mortz CG,Gowland MH,Timmermans F,Roberts G

    更新日期:2020-08-01 00:00:00

  • Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus-predominant subgroup.

    abstract:BACKGROUND:Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti-microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio....

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14058

    authors: Diver S,Richardson M,Haldar K,Ghebre MA,Ramsheh MY,Bafadhel M,Desai D,Cohen ES,Newbold P,Rapley L,Rugman P,Pavord ID,May RD,Barer M,Brightling CE

    更新日期:2020-04-01 00:00:00

  • Perennial allergic rhinitis and chronic sinusitis: correlation with rhinologic risk factors.

    abstract:BACKGROUND:The reported association of allergy and sinusitis varies greatly between study, and the exact role of allergy in predisposing to sinusitis is not clear. We attempted to determine whether patients with perennial allergic rhinitis are at greater risk of developing sinusitis with respect to a control group, and...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00813.x

    authors: Berrettini S,Carabelli A,Sellari-Franceschini S,Bruschini L,Abruzzese A,Quartieri F,Sconosciuto F

    更新日期:1999-03-01 00:00:00

  • Skin prick test reactivity to common allergens in Finnish adolescents.

    abstract::We studied 708 adolescents aged 15-17 years in the 9th grade of school in Imatra. Of the eligible population born in 1962 77% were included. All were skin prick tested with 16 extracts from two manufacturers with 12 common allergens, which included pollens, epithelia, mite, house dust and fish. At least one positive, ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1980.tb01789.x

    authors: Haahtela T,Björkstén F,Heiskala M,Suoniemi I

    更新日期:1980-07-01 00:00:00

  • Human herpes virus reactivations and dynamic cytokine profiles in patients with cutaneous adverse drug reactions --a prospective comparative study.

    abstract:BACKGROUND:Sequential human herpes virus (HHV) reactivation is well known in drug reaction with eosinophilia and systemic symptom (DRESS), but such a phenomenon has seldom studied in other types of cutaneous adverse drug reactions (cADRs). Moreover, the association between viral reactivations and cytokine or chemokine ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12602

    authors: Chen YC,Chiang HH,Cho YT,Chang CY,Chen KL,Yang CW,Lee YH,Chu CY

    更新日期:2015-05-01 00:00:00

  • Increased CD69 expression on peripheral blood eosinophils after specific inhalation challenge.

    abstract:BACKGROUND:CD69 is a molecule expressed on human eosinophils after cytokine-activation. Different studies have described the eosinophil activation, evaluated by CD69 expression, at the site of an allergic inflammation. In this study we evaluated the expression of CD69 on peripheral blood eosinophils after a specific in...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23454.x

    authors: Pignatti P,Perfetti L,Galdi E,Pozzi V,Bossi A,Biale C,Moscato G

    更新日期:2002-05-01 00:00:00

  • Plasma protein profiles in early asthmatic responses to inhalation allergen challenge.

    abstract::Although mediators, such as lipids, cytokines, and chemokines, are related to the appearance of an IPR, there has been no reliable indicator to predict conditions for the appearance of an IPR. In this study, we adopted a proteomic approach to investigate the pathogenesis at the level of the plasma proteins and to deve...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01817.x

    authors: Rhim T,Choi YS,Nam BY,Uh ST,Park JS,Kim YH,Paik YK,Park CS

    更新日期:2009-01-01 00:00:00

  • Impairment of T helper and T regulatory cell responses at birth.

    abstract:BACKGROUND:There is strong evidence that reduced exposures to microbial compounds triggering innate immune responses early in life are critical for the development of allergic illnesses. The underlying mechanisms remain unknown, but will include T-cell responses either along T helper type 1 (Th1)/Th2 pathways or via T ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01685.x

    authors: Schaub B,Liu J,Schleich I,Höppler S,Sattler C,von Mutius E

    更新日期:2008-11-01 00:00:00

  • Level of asthma control and healthcare utilization in Latin America.

    abstract::The purpose of this study was to investigate whether uncontrolled asthma was associated with healthcare outcomes among Latin American patients with asthma. We used data from 2168 patients with asthma who participated in the 2011 Latin America Asthma Insights and Management (AIM) survey. Using Global Initiative for Ast...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12237

    authors: Gold LS,Montealegre F,Allen-Ramey FC,Jardim J,Smith N,Sansores R,Sullivan SD

    更新日期:2013-11-01 00:00:00

  • Activation of basophils by the double-stranded RNA poly(A:U) exacerbates allergic inflammation.

    abstract:BACKGROUND:It is commonly acknowledged that asthma is exacerbated by viral infections. On the other hand, basophil infiltration of lung tissues has been evidenced postmortem in cases of fatal disease, raising the question of a possible link between these two observations. OBJECTIVES:Herein, we addressed the relationsh...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12151

    authors: Ramadan A,Pham Van L,Machavoine F,Dietrich C,Alkan M,Karasuyama H,Schneider E,Dy M,Thieblemont N

    更新日期:2013-06-01 00:00:00

  • Monitoring of serologic immune parameters in inflammatory skin diseases.

    abstract::This paper deals with the correlation of clinical scoring and serologic markers of inflammation in atopic dermatitis and psoriasis. Serum eosinophil cationic protein (ECP), soluble interleukin-2 receptor (sIL-2R), total serum IgE, IgG and IgM anti-IgE antibodies, and IgE immune complexes were evaluated in monitoring i...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb00180.x

    authors: Gebhardt M,Wenzel HC,Hipler UC,Herrmann D,Wollina U

    更新日期:1997-11-01 00:00:00

  • Astemizole in the treatment of hay fever.

    abstract::A double-blind parallel trial of astemizole, pheniramine and placebo was carried out in 51 patients with hay fever. Astemizole is a new potent H1-antihistamine with long duration of action but devoid of central activity. Evaluation criteria were daily symptom- and side effect score cards, daily nasal peak flow measure...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1983.tb01615.x

    authors: Malmberg H,Holopainen E,Grahne B,Binder E,Savolainen S,Sundberg S

    更新日期:1983-05-01 00:00:00

  • Pharyngeal edema caused by occupational exposure to cellulase enzyme.

    abstract::Enzymes can cause allergic asthma and rhinitis. Although patients sometimes complain of symptoms in their throat, we have not been able to find any published report of pharyngeal edema caused by exposure to enzymes. We present the case of a maintenance foreman who worked in a factory producing enzymes, and who had pha...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02103.x

    authors: Hytönen M,Vanhanen M,Keskinen H,Tuomi T,Tupasela O,Nordman H

    更新日期:1994-10-01 00:00:00

  • A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis.

    abstract:BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02444.x

    authors: Wang H,Chavali S,Mobini R,Muraro A,Barbon F,Boldrin D,Aberg N,Benson M

    更新日期:2011-01-01 00:00:00

  • Positivity of patch tests in cutaneous reaction to aminocaproic acid: two case reports.

    abstract::We observed two cases of maculopapular eruption occurring 12-72 h after the administration of aminocaproic acid (ACA). Patch tests performed with ACA were positive. Clinical and allergologic patterns suggest the type IV mechanism of hypersensitivity. We present what we believe are the first two cases described of hype...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb01217.x

    authors: González Gutiérrez ML,Esteban López MI,Ruíz Ruíz MD

    更新日期:1995-09-01 00:00:00

  • A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma.

    abstract:BACKGROUND:The cysteinyl leukotrienes (cysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as potent bronchoconstrictors, cysLTs contribute to airway inflammation through eosinophil and neutrophil chemotaxis, plasma exudation, and mucus secretion. We tested the activity of the dual cysL...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/all.12987

    authors: Gauvreau GM,Boulet LP,FitzGerald JM,Cockcroft DW,Davis BE,Leigh R,Tanaka M,Fourre JA,Tanaka M,Nabata T,O'Byrne PM

    更新日期:2016-12-01 00:00:00