Placebo-controlled challenges with perfume in patients with asthma-like symptoms.

Abstract:

:A group of nine patients with respiratory symptoms after nonspecific irritating stimuli, but without any IgE-mediated allergy or demonstrable bronchial obstruction, were referred to the asthma/allergy outpatient department for evaluation of suspected asthma. In order to find a provocation model and objectively assess these patients' symptoms in controlled studies, provocation with perfume or placebo was performed. The same patients were also subjected to perfume provocation with or without a carbon filter mask to ascertain whether breathing through a filter with active carbon could prevent the symptoms. The patients breathed through the mouth during the provocations, as they used a nasal clamp to prevent any smell of perfume. We found that the patients' earlier symptoms could be verified by perfume provocation. Breathing through the carbon filter had no protective effect. The conclusion is that symptoms suggesting hyperreactivity of the respiratory tract and asthma can be provoked by perfume without the presence of bronchial obstruction, and that using a carbon filter mask has no preventive effect. The symptoms are not transmitted via the olfactory nerve, since the patients could not smell the perfume, but they may have been induced by a trigeminal reflex via the respiratory tract or by the eyes.

journal_name

Allergy

journal_title

Allergy

authors

Millqvist E,Löwhagen O

doi

10.1111/j.1398-9995.1996.tb04644.x

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

434-9

issue

6

eissn

0105-4538

issn

1398-9995

journal_volume

51

pub_type

临床试验,杂志文章,随机对照试验

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