Abstract:
BACKGROUND:Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce. METHODS:A prospective, longitudinal, web-based survey of 'real-life' respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded according to the Medical Dictionary for Regulatory Activities (MedDRA) and risk factors associated with SRs were identified. RESULTS:A total of 4316 patients (corresponding to 4363 ongoing courses of AIT) were included. A total of 109 SRs were recorded, and 90 patients (2.1%) presented at least one SR. Most of the SRs occurred in subcutaneous allergen immunotherapy (SCIT) (89%, n = 97). The most frequently reported symptoms were urticaria, rhinitis, dyspnoea and cough. Respiratory symptoms appeared before skin symptoms. Most SRs occurred during the up-dosing phase (75.8%) and were mild in severity (71.6%). Intramuscular adrenaline was administered in 17 SRs, but only 65% of these were subsequently classified as anaphylaxis. Independent risk factors for SRs during SCIT were as follows: the use of natural extracts (odds ratio, OR) [95% confidence interval (CI)] = 2.74 [1.61-4.87], P = 0.001), the absence of symptomatic allergy medications (1.707 [1.008-2.892], P = 0.047), asthma diagnosis (1.74 [1.05-2.88], P = 0.03), sensitization to animal dander (1.93 [1.21-3.09], P = 0.006) or pollen (1.16 [1.03-1.30], P = 0.012) and cluster regimens (vs rush) (4.18 [1.21-14.37], P = 0.023). A previous episode of anaphylaxis increased the risk for anaphylaxis in SCIT (OR [95% CI] = 17.35 [1.91-157.28], P = 0.01). CONCLUSION:AIT for respiratory allergy is safe, with a low number of SRs observed in real-life clinical practice. A personalized analysis of risk factors could be used to minimize SRs.
journal_name
Allergyjournal_title
Allergyauthors
Calderón MA,Vidal C,Rodríguez Del Río P,Just J,Pfaar O,Tabar AI,Sánchez-Machín I,Bubel P,Borja J,Eberle P,Reiber R,Bouvier M,Lepelliez A,Klimek L,Demoly P,EASSI Doctors' Group.doi
10.1111/all.13066subject
Has Abstractpub_date
2017-03-01 00:00:00pages
462-472issue
3eissn
0105-4538issn
1398-9995journal_volume
72pub_type
杂志文章相关文献
ALLERGY文献大全abstract::Specific Immunotherapy for respiratory allergy is used since about one century and there is now solid documentation of its efficacy. Nevertheless, the methods and experimental designs used in clinical trials are quite heterogeneous and there is no unanimously accepted methodological standard. Many studies are planned ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2006.01312.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01414.x
更新日期:2007-08-01 00:00:00
abstract::An affinity chromatography method for preparation of patient-related antigens from commercially available allergen extracts has been investigated. IgG1,2,4 from a patient previously hyposensitized with dog hair and dandruff allergen was bound to protein A-sepharose. Secondly, commercial allergen extract was applied to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb00927.x
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Investigation of preschool asthma is important since not all children outgrow their illness during this age. Data are scarce on the role of rhinovirus (RV) infections in this patient group. OBJECTIVES:To investigate the role of RV infections in preschool asthma: (i) susceptibility factors, (ii) clinical cou...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14479
更新日期:2021-01-01 00:00:00
abstract::The role of cytokines in the accumulation of eosinophil granulocytes in inflamed tissue has been studied extensively during recent years, and these molecules have been found to participate throughout the whole process of eosinophil recruitment. Haematopoietic cytokines such as IL-3, IL-5 and GM-CSF stimulate the proli...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2004.00469.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Recent studies have yielded heterogeneous results regarding the relationship between vitamin D and atopic conditions. The aim of this study was to investigate the association between serum vitamin D level and the prevalence of eczema in German children and adolescents. METHODS:Data were drawn for children a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12167
更新日期:2013-07-01 00:00:00
abstract:RATIONALE:The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control. OBJECTIVES:To study the degree of CRS c...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12983
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Epicutaneous sensitization is an important route of immunization for allergens in atopic diseases; however, studies have also shown that application with protein on the intact skin induces antigen-specific tolerance. Langerhans cells (LCs) play an immunosuppressive role in several inflammatory skin diseases ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13813
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Genomewide association studies (GWASs) of asthma have identified single-nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to identify susceptibilit...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12990
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Although atopic sensitization is one of the strongest risk factors for asthma, its relationship with asthma is poorly understood. We hypothesize that 'atopy' encompasses multiple sub-phenotypes that relate to asthma in different ways. METHODS:In two population-based birth cohorts (Manchester and Isle of Wig...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12134
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Undernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-spe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02829.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk of the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common conclusion. We investigated ...
journal_title:Allergy
pub_type: 杂志文章,meta分析
doi:10.1111/all.12589
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The beta-lactam allergic work-up is mostly standardized. However, the negative predictive value of drug provocation tests is not yet well established. METHOD:A historical-prospective multicentre cohort study was conducted in four centres (one in France, one in Portugal, two in Italy) to assess the negative ...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1398-9995.2009.02228.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Blomia tropicalis is an important mite species in the tropical and sub-tropical regions of the world. Blo t 5 is the major allergen with up to 70% sensitization rates in B. tropicalis allergic populations. METHODS:Mice were immunized intramuscularly with naked plasmid DNA encoding Blo t 5 gene with in vivo ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00597.x
更新日期:2005-01-01 00:00:00
abstract::The scarce data published on mite sensitization and mite-allergen levels in Norway indicate that the mites may not be of the same importance in allergic disease in Norway as in countries such as the UK and the rest of Europe. The problem also involves the low allergen levels and small amounts of dust collected for all...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1998.tb04999.x
更新日期:1998-01-01 00:00:00
abstract::There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12390
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13161
更新日期:2017-09-01 00:00:00
abstract::The nasal mucociliary clearance is an important defense mechanism of the upper respiratory tract. It is known to be influenced by many pharmacologic substances. We investigated the effects of three topical intranasal antiallergic formulations containing disodium cromoglycate (DNCG), dimethindene maleate (DMM), and aze...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03801.x
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Immunoglobulin E (IgE)-mediated allergy belongs to common chronic disorders resulting from an interaction between both genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31.1, a region that is linked to asthma and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00271.x
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Asthma-like symptoms in young children are orchestrated by the local airway immune response, but current knowledge largely relies on in vitro airway models. Azithromycin has been shown to reduce the duration of episodes with asthma-like symptoms, but efficacy may depend on the individual child's immune respo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14651
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2007.01473.x
更新日期:2008-01-01 00:00:00
abstract::The IgE-binding components of date palm (Phoenix dactylifera L.) pollen were determined by ELISA and Western blotting in atopic patients in order to identify its major allergens. From a pool of previously identified allergenic fractions and sera from 15 skin-test-positive, atopic subjects, four components of 12, 14.4,...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb01107.x
更新日期:1993-10-01 00:00:00
abstract::The clinical effects in asthma of corticosteroids can be ascribed to their strong anti-inflammatory action. The pathophysiology of asthma is complex. A diversity of mediators and interactions between mediators and between mediators and various cell types enhances and maintains the inflammatory process in the airways r...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1988.tb00908.x
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Recent studies showed the presence of a unique dust-mite fauna in the indoor environment of Singapore. Immediate hypersensitivity to these dust mites, along with other known indoor allergens, may play a role in the pathogenesis of allergic respiratory diseases. This study evaluated the sensitization rates of...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00050.x
更新日期:1999-11-01 00:00:00
abstract::The presence of indoor allergens in Finnish homes was studied for the first time. Dust samples (n = 30) were collected by vacuuming a 1 m2 area from a living-room carpet in 30 apartments divided into three groups: homes with cats (n = 10), homes with dogs (n = 10), and homes without pets (n = 10). The levels of major ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03870.x
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Hen's egg (HE) allergy is a common disease in childhood. HE-specific serum IgE has been correlated with the outcome of oral food challenge tests, and diagnostic decision points have been described as helpful but still not sufficient to reduce the requirement for oral food challenges. The aim of the study was...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02429.x
更新日期:2010-12-01 00:00:00
abstract::Olea europaea (olive) pollen extract was prepared by aqueous extraction and characterized by biochemical and immunochemical methods. Two components, displaying respective mol. wt. of 17,000 and 19,000, were the most reactive allergens, being the doublet (designated Ole e I) recognized by most sera tested. The 19,000 m...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb00724.x
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The cysteinyl leukotrienes (cysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as potent bronchoconstrictors, cysLTs contribute to airway inflammation through eosinophil and neutrophil chemotaxis, plasma exudation, and mucus secretion. We tested the activity of the dual cysL...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/all.12987
更新日期:2016-12-01 00:00:00
abstract::House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for a range of allergic conditions. Technological advances have accelerated the identification of these allergens and characterized their putative roles within HDMs. Understanding their functional bioactivities is illuminating how ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13940
更新日期:2020-01-01 00:00:00
abstract::Thirty children with rhinoconjunctivitis due to birch pollinosis were treated in a double blind manner for 10 months with enteric-coated capsules containing either a birch pollen preparation (n = 14) with doses up to 1.4 X 10(6) biologic units per day or placebo (n = 16). Compared with the placebo group the actively t...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1986.tb02028.x
更新日期:1986-05-01 00:00:00