Abstract:
:The nasal mucociliary clearance is an important defense mechanism of the upper respiratory tract. It is known to be influenced by many pharmacologic substances. We investigated the effects of three topical intranasal antiallergic formulations containing disodium cromoglycate (DNCG), dimethindene maleate (DMM), and azelastine-HCL (AZL) on nasal ciliary beat frequency (CBF) in vitro. Nasal ciliated cells were harvested from 16 healthy volunteers. Cells were diluted 1:10 in culture medium and incubated with a placebo formulation (PLAC), containing 0.022% benzalkonium chloride, which was part of all formulations, a registered 2% formulation of DNCG, a 0.1% formulation of DMM, and a registered 0.1% formulation of AZL. After an incubation period of 20 min, CBF was registered by a photoelectric measurement device. Under control conditions (CONTROL), CBF was 11.4 +/- 1.3 Hz. PLAC reduced CBF to 9.7 +/- 2.3 Hz (NS). DNCG reduced CBF to 9.7 +/- 2 Hz (NS). DMM reduced CBF to 7.2 +/- 1.7 Hz (P < or = 0.05 vs CONTROL, NS vs PLAC), and AZL reduced CBF to 0.9 +/- 1.8 Hz (P < or = 0.001 vs CONTROL, P < or = 0.001 vs DNCG, P < or = 0.001 vs PLAC). In conclusion, a possible influence of antiallergic intranasal formulations on nasal ciliary function has to be considered in clinical application.
journal_name
Allergyjournal_title
Allergyauthors
Alberty J,Stoll Wdoi
10.1111/j.1398-9995.1998.tb03801.xsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
986-9issue
10eissn
0105-4538issn
1398-9995journal_volume
53pub_type
杂志文章相关文献
ALLERGY文献大全abstract:BACKGROUND:Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract. OBJECTIVE:To identify and characterize kirola, the 17-kDa protein of green kiwifruit (Act d 11). METHODS:Act d 11 was purified from green ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02555.x
更新日期:2011-07-01 00:00:00
abstract::In a study conducted 1 year ago, we found that Th1 immune enhancement following Bacille Calmette-Guérin (BCG) vaccination effectively suppressed human asthma. To investigate whether revaccination would further improve lung function, BCG vaccine was given again. Current lung function tended to improve in the Repeated B...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1034/j.1398-9995.2003.00246.x
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056002175.x
更新日期:2001-02-01 00:00:00
abstract::The possible dependence of the dual cutaneous reaction (DCR) on activation of the complement and coagulation systems was further elucidated. Heterologous whole anti-human IgE was injected intradermally (i.d.) on the volar aspect of the forearms of 17 drug-free healthy volunteers and venous samples for the selected lab...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1985.tb00883.x
更新日期:1985-11-01 00:00:00
abstract::We developed an antigen- and isotype-specific ELISA for the rapid detection of native serum immune complexes (IC). It is a sandwich assay, in which a solid phase antigen-specific capture antibody selectively binds the antigen-specific IC via the antigen. The isotype of the bound IC is then identified using an enzyme-l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb01626.x
更新日期:1988-10-01 00:00:00
abstract::We investigated the relationship between residence in the neighbourhood of an aluminium smelter and the prevalence of atopy in schoolchildren (7-13 years of age). Atopy was assessed in 556 of the 620 participants by a skin prick test with eight common aeroallergens. The median exposures to sulphur dioxide and fluoride...
journal_title:Allergy
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosano...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12010
更新日期:2012-11-01 00:00:00
abstract::House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for a range of allergic conditions. Technological advances have accelerated the identification of these allergens and characterized their putative roles within HDMs. Understanding their functional bioactivities is illuminating how ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13940
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13161
更新日期:2017-09-01 00:00:00
abstract::Olea europaea (olive) pollen extract was prepared by aqueous extraction and characterized by biochemical and immunochemical methods. Two components, displaying respective mol. wt. of 17,000 and 19,000, were the most reactive allergens, being the doublet (designated Ole e I) recognized by most sera tested. The 19,000 m...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb00724.x
更新日期:1993-05-01 00:00:00
abstract::An affinity chromatography method for preparation of patient-related antigens from commercially available allergen extracts has been investigated. IgG1,2,4 from a patient previously hyposensitized with dog hair and dandruff allergen was bound to protein A-sepharose. Secondly, commercial allergen extract was applied to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb00927.x
更新日期:1988-11-01 00:00:00
abstract::Eighteen children with perennial asthma and allergy to house-dust mite (HDM) underwent a bronchial challenge with HDM. Before and 24 h after the test, a venous blood sample was taken to determine levels of eosinophils, eosinophil cationic protein (ECP), soluble interleukin-2 receptor (IL-2R), and interleukin-6 (IL-6)....
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb00742.x
更新日期:1993-08-01 00:00:00
abstract::Women's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregati...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14317
更新日期:2020-11-01 00:00:00
abstract::Children with recurrent lower respiratory tract infection (RLRI) may respond poorly to polysaccharide antigens. To examine how such children respond to a polysaccharide coupled to a protein carrier, we immunized 15 children with RLRI aged 8-69 months and 15 carefully age-matched healthy controls once with a Haemophilu...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb01192.x
更新日期:1995-06-01 00:00:00
abstract::The study aimed to determine whether occupational contact urticaria and symptoms of mucous membranes, reported by five workers in a cactus nursery, were due to IgE-mediated allergy to Schlumbergera cacti. The five persons had positive skin prick tests to the plants as is and positive histamine-release tests, and in th...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb01045.x
更新日期:1997-06-01 00:00:00
abstract::Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being statistically slowe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1979.tb04376.x
更新日期:1979-10-01 00:00:00
abstract::Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is wid...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02753.x
更新日期:2012-03-01 00:00:00
abstract::This update aimed to review the new evidence available to support or refute prior Allergic Rhinitis and its Impact on Asthma (ARIA) statements. A Medline search of publications between 2000 and 2005 was conducted, with articles selected by experts. New evidence supports previous ARIA statements, such as: (i) allergic ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01551.x
更新日期:2007-01-01 00:00:00
abstract::Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to asthma, allergies, and allied diseases. Prostaglandins and leukotrienes are the most studied eicosanoids and established inducers of air...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14295
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses and is frequently divided into polypoid CRS (CRSwNP) and nonpolypoid CRS (CRSsNP). However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the s...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02706.x
更新日期:2012-01-01 00:00:00
abstract::In vitro challenge of peripheral white blood cells (WBC) from 62 food sensitive patients and 22 asymptomatic control individuals was performed using standardized extract of cow milk, corn and wheat. 81% of the patients reacted at least toward one food antigen, showing disintegration of WBC, as measured by trypan blue ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1985.tb00211.x
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:It is currently believed that most fungal exposure occurs external to the home. AIMS:To enumerate the fungal flora of used synthetic and feather pillows and the dust vacuumed from them, in the UK. METHODS:10 pillows aged between 1.5 and >20 years in regular use were collected and quantitatively cultured fo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00941.x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Measurement of exposure to the dust mite allergen Der p 1 is important in asthma research and is potentially useful in managing asthma. As no single measure can capture all characteristics of an exposure, it is important to recognize differences in the available methods of measuring exposure to Der p 1. MET...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00228.x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:The Gaining Optimal Asthma ControL (GOAL) study has shown the superiority of a combination of salmeterol/fluticasone propionate (SFC) compared with fluticasone propionate alone (FP) in terms of improving guideline defined asthma control. METHODS:Clinical and economic data were taken from the GOAL study, sup...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2006.01038.x
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:We report a series of 24 health-care workers with respiratory symptoms suggestive of occupational asthma due to glutaraldehyde exposure. METHODS:The history of asthmatic symptoms was investigated with peak expiratory flow rate (PEFR) monitoring, and in eight of the subjects, the specific bronchial provocati...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00239.x
更新日期:1999-10-01 00:00:00
abstract::The yeast Pityrosporum orbiculare (P. orbiculare) is a member of the normal human cutaneous flora, but it is also associated with several clinical manifestations of the skin. We have previously observed IgE-binding components in P. orbiculare extracts, using sera from patients with atopic dermatitis. In the present st...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00773.x
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:There has been no study for evaluating the associations of human leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate (TDI)-induced asthma in an Asian population. OBJECTIVE:The aim of this study was to investigate a susceptible or protective marker of HLA class I and II alleles in TDI-in...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01023.x
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2007.01466.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02846.x
更新日期:2012-07-01 00:00:00
abstract::This paper deals with the correlation of clinical scoring and serologic markers of inflammation in atopic dermatitis and psoriasis. Serum eosinophil cationic protein (ECP), soluble interleukin-2 receptor (sIL-2R), total serum IgE, IgG and IgM anti-IgE antibodies, and IgE immune complexes were evaluated in monitoring i...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb00180.x
更新日期:1997-11-01 00:00:00