Abstract:
:The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulation was noted in 17 patients, but in none of 10 healthy controls. There was close relationship between basophil "releasability" to polymyxin B and bronchial reactivity to inhaled polymyxin B. These findings support the hypothesis.
journal_name
Allergyjournal_title
Allergyauthors
Górski P,Rozniecki J,Kuźmińska B,Grzegorczyk Jdoi
10.1111/j.1398-9995.1985.tb04157.xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
70-2issue
1eissn
0105-4538issn
1398-9995journal_volume
40pub_type
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