Bronchial and basophil reaction to polymyxin B in asthmatic patients.

Abstract:

:The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulation was noted in 17 patients, but in none of 10 healthy controls. There was close relationship between basophil "releasability" to polymyxin B and bronchial reactivity to inhaled polymyxin B. These findings support the hypothesis.

journal_name

Allergy

journal_title

Allergy

authors

Górski P,Rozniecki J,Kuźmińska B,Grzegorczyk J

doi

10.1111/j.1398-9995.1985.tb04157.x

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

70-2

issue

1

eissn

0105-4538

issn

1398-9995

journal_volume

40

pub_type

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