Abstract:
BACKGROUND:Little information is available on the clinical efficacy of sublingual immunotherapy (SLIT) using extracts derived from mammalian epithelia. OBJECTIVES:To assess clinical efficacy of cat SLIT based on natural exposure challenge test (NCT). MATERIAL AND METHODS:Fifty cat allergic patients with rhinoconjunctivitis with or without asthma were included in a randomized double blind placebo controlled clinical trial of cat SLIT during 1 year. Twenty-five patients received active treatment and 25 placebo. Sublingual immunotherapy efficacy was assessed by natural exposure challenge to a cat in a cat-room and by skin tests. Airborne Fel d 1 levels, symptom scores and peak expiratory flow (PEF) values were monitored. RESULTS:Thirty-three (66%) out of 50 patients completed the treatment. Fel d 1 content of the maximum concentration was 0.51 microg per ml. During the build up phase, the accumulated dose was 1.7 mug of Fel d 1 and during the entire length of the study was 17.1. No adverse reports were reported. The active group showed a marked reduction (62%) in symptoms during the NCT (P < 0.001) with no changes in placebo group. Active group also showed a reduced PEF response to cat exposure (P < 0.05), and an improvement in skin test reactivity to a standardized cat extract (P < 0.05), without significant changes in placebo group. Mean Fel d 1 exposure during the NCT was 6.2 +/- 2.21 ng/m(3). CONCLUSIONS:The results suggest that the cat SLIT used in this study was able to improve cat allergy based on natural exposure challenge.
journal_name
Allergyjournal_title
Allergyauthors
Alvarez-Cuesta E,Berges-Gimeno P,González-Mancebo E,Fernández-Caldas E,Cuesta-Herranz J,Casanovas Mdoi
10.1111/j.1398-9995.2007.01365.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
810-7issue
7eissn
0105-4538issn
1398-9995pii
ALL1365journal_volume
62pub_type
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