Increased circulating platelet microparticles as a potential biomarker in asthma.

Abstract:

BACKGROUND:Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. METHODS:In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. RESULTS:Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). CONCLUSIONS:We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

journal_name

Allergy

journal_title

Allergy

authors

Duarte D,Taveira-Gomes T,Sokhatska O,Palmares C,Costa R,Negrão R,Guimarães JT,Delgado L,Soares R,Moreira A

doi

10.1111/all.12190

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

1073-5

issue

8

eissn

0105-4538

issn

1398-9995

journal_volume

68

pub_type

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