Prolactin and contact sensitivity.

Abstract:

:Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.

journal_name

Allergy

journal_title

Allergy

authors

Nagy E,Berczi I

doi

10.1111/j.1398-9995.1981.tb01850.x

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

429-31

issue

6

eissn

0105-4538

issn

1398-9995

journal_volume

36

pub_type

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