Abstract:
:Dose- and pH- dependent carbodiimide-mediated coupling of Penicillin-G to polystyrene microtiter-plates that leaves the beta-lactam ring unchanged is described. A new ELISA method was developed using Penicillin-G coated plates. The binding of 3 different monoclonal antibodies as well as human IgG antibodies of the IgG1 and IgG3 subclasses is demonstrated, whereas IgG2, IgG4 and IgE antibodies did not bind. Thus, covalently coupled Penicillin-G can be used to study the immune-response to the unchanged beta-lactam ring in patients receiving penicillin therapy. The new method is complementary to hitherto described techniques, which generally only allow detection of antibodies binding to penicilloyl-groups.
journal_name
Allergyjournal_title
Allergyauthors
Klein GF,Stanzl U,Fritsch PO,Varga JMdoi
10.1111/j.1398-9995.1993.tb00705.xsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
151-7issue
3eissn
0105-4538issn
1398-9995journal_volume
48pub_type
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