Immune mechanisms of allergen-specific sublingual immunotherapy.

abstract：BACKGROUND:Hen's egg (HE) allergy is a common disease in childhood. HE-specific serum IgE has been correlated with the outcome of oral food challenge tests, and diagnostic decision points have been described as helpful but still not sufficient to reduce the requirement for oral food challenges. The aim of the study was...

journal_title：Allergy

authors： Ahrens B,Lopes de Oliveira LC,Schulz G,Borres MP,Niggemann B,Wahn U,Beyer K

更新日期：2010-12-01 00:00:00

abstract：:The red cell-linked antigen-antiglobulin reaction (RCLAAR) with stearoyldextran-coated erythrocytes was used to characterize the immunoglobulin (Ig) classes and IgG subclasses of dextran reactive antibodies (DRA) in 27 dextran reactors (DR) and 96 on reactors (DNR). High titres of dextran reactive IgG were regularly f...

journal_title：Allergy

authors： Kraft D,Hedin H,Richter W,Scheiner O,Rumpold H,Devey ME

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most ...

journal_title：Allergy

authors： Doña I,Jurado-Escobar R,Perkins JR,Ayuso P,Plaza-Serón MC,Pérez-Sánchez N,Campo P,Bogas-Herrera G,Bartra J,Torres MJ,Sanak M,Cornejo-García JA

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:It has been suggested that human breast milk oligosaccharides play a role in the development of the immune system in infants, and may consequently inhibit the onset of allergy. A specific prebiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GOS/FOS) has been shown...

journal_title：Allergy

authors： van Hoffen E,Ruiter B,Faber J,M'Rabet L,Knol EF,Stahl B,Arslanoglu S,Moro G,Boehm G,Garssen J

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Mastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis factor-related apoptosis-inducing ligand receptors (TRAIL-Rs) are preferentially expressed on neoplastic cells and induce the extrinsic apoptotic pathway. Recent studies reported ...

journal_title：Allergy

authors： Förster A,Grotha SP,Seeger JM,Rabenhorst A,Gehring M,Raap U,Létard S,Dubreuil P,Kashkar H,Walczak H,Roers A,Hartmann K

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Adolescents with food allergy have poorer psychosocial outcomes compared with their nonallergic counterparts; however, few studies have prospectively examined the mental health of adolescents and young adults in this vulnerable population. Our objectives were to estimate the prevalence of emotional and behav...

journal_title：Allergy

authors： Ferro MA,Van Lieshout RJ,Ohayon J,Scott JG

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract. OBJECTIVE:To identify and characterize kirola, the 17-kDa protein of green kiwifruit (Act d 11). METHODS:Act d 11 was purified from green ...

journal_title：Allergy

authors： D'Avino R,Bernardi ML,Wallner M,Palazzo P,Camardella L,Tuppo L,Alessandri C,Breiteneder H,Ferreira F,Ciardiello MA,Mari A

更新日期：2011-07-01 00:00:00

abstract：:The aim of the study was to determine whether IgG antibodies from patients on specific immunotherapy could inhibit skin test reactivity of allergens when mixed with them prior to testing. In a preliminary double-blind study, mite extracts were incubated with glycero-saline solution or non-specific IgG and used in test...

journal_title：Allergy

authors： Pecquet C,Murrieta M,Michelen V,Leynadier F,Dry J,Allary M,Fabre G,Saint-Blancard J

更新日期：1989-08-01 00:00:00

abstract：:A common feature of environmental irritants is their ability to cause local inflammation which could alter airway function. The principal targets of such injury are the epithelial cells lining the airway passages and the lower respiratory gas-exchange areas. While host atopy is a recognized risk factor for airway infl...

journal_title：Allergy

authors： Spiteri MA,Bianco A,Strange RC,Fryer AA

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Several epidemiologic studies in the United States and Europe have linked Alternaria sensitivity to both persistence and severity of asthma. In this study, we examined T cell responses and HLA class II alleles in children with moderate-severe asthma. METHODS:Ninety-six children with moderate-severe asthma w...

journal_title：Allergy

authors： Knutsen AP,Vijay HM,Kumar V,Kariuki B,Santiago LA,Graff R,Wofford JD,Shah MR

更新日期：2010-11-01 00:00:00

abstract：:House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies, could detect 0.5-1.5 ng/ml of specific ant...

journal_title：Allergy

authors： Einarsson R,Dreborg S,Hammarström L,Löfkvist T,Smith CI,Svensson G

更新日期：1992-04-01 00:00:00

abstract：:The incidence of positive skin test responses among atopic subjects with suspected respiratory allergy was investigated with commercial and autochthonous pollen extracts of various cultivars of Olea europaea. Pollen was collected from olive trees of well-defined cultivars, extracted, and separated by SDS-PAGE. Immunob...

journal_title：Allergy

authors： Waisel Y,Geller-Bernstein C,Keynan N,Arad G

更新日期：1996-11-01 00:00:00

abstract：:The present study was designed to investigate the effects of immunotherapy (IT) with an extract of Dermatophagoides pteronyssinus (Alergo-Merck Depot) during a 27-month period in patients with allergic asthma to house-dust mites. We included 11 patients (mean age 18 years) treated with a combination of IT and inhaled ...

journal_title：Allergy

authors： Costa JC,Plácido JL,Silva JP,Delgado L,Vaz M

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Food allergy affects approximately 5% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. The mucosal adjuvant cholera toxin induces allergic sensitization to co-administered proteins in mice, while feeding the protein alone induces oral tolerance. Int...

journal_title：Allergy

authors： Bol-Schoenmakers M,Marcondes Rezende M,Bleumink R,Boon L,Man S,Hassing I,Fiechter D,Pieters RH,Smit JJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2-lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma. OBJECTIVE:We hypothesize...

journal_title：Allergy

authors： Wang TN,Chiang W,Tseng HI,Chu YT,Chen WY,Shih NH,Ko YC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Supermarket bakers are exposed not only to flour and alpha-amylase but also to other 'improver' enzymes, the nature of which is usually shrouded by commercial sensitivity. We aimed to determine the prevalence of sensitization to 'improver' enzymes in UK supermarket bakers. METHODS:We examined the prevalence...

journal_title：Allergy

authors： Jones M,Welch J,Turvey J,Cannon J,Clark P,Szram J,Cullinan P

更新日期：2016-07-01 00:00:00

abstract：UNLABELLED:We evaluated the ENEA System, a fully automated instrument for the measurement of specific IgE antibodies. The instrument dispenses sera and reagents, incubates, washes, and reads and prints results automatically. The "core" of the instrument is the reactive unit called ACE (Allergy Chamber Enzymatic), which...

journal_title：Allergy

authors： Plebani M,Faggian D,Borghesan F

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Succinate, in addition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and propagating danger signals resulting from tissue injury or inflammatory stimuli. The contribution of this immune sensing pathway to the development of allergic and inflammatory responses is unkn...

journal_title：Allergy

authors： Rubić-Schneider T,Carballido-Perrig N,Regairaz C,Raad L,Jost S,Rauld C,Christen B,Wieczorek G,Kreutzer R,Dawson J,Lametschwandner G,Littlewood-Evans A,Carballido JM

更新日期：2017-03-01 00:00:00

abstract：:The levels of peripheral-blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics and 10 nonatopics) were measured by postcolumn derivatization high-performance liquid chromatography analysis. None of the patients, except the 44-yea...

journal_title：Allergy

authors： Kurosawa M,Shimizu Y,Tsukagoshi H,Ueki M

更新日期：1992-12-01 00:00:00

abstract：:In analogy with findings from animal experiments, people with low glutathione-peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of...

journal_title：Allergy

authors： Malmgren R,Unge G,Zetterström O,Theorell H,de Wahl K

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Patch testing is the standard clinical procedure to prove contact sensitization. It is a common practice to attach multiple patch tests at the same time. However, synchronous reactions to unrelated allergens may not be completely unassociated. If so, the reaction in a given test field might be influenced by ...

journal_title：Allergy

authors： Brasch J,Geier J,Schnuch A,Uter W,German Contact Dermatitis Research Group (DKG).,Information Network of Departments of Dermatology (IVDK).

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Mastocytosis is a heterogeneous disease characterized by a clonal expansion of mast cells in various organs. The vast majority of patients suffer from signs and symptoms caused by mediator release from mast cells. Although the disease burden is high, there is currently no specific and validated instrument to...

journal_title：Allergy

authors： Siebenhaar F,Sander B,Ho LHT,Ellrich A,Maurer M,Weller K

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...

journal_title：Allergy

authors： Suaini NHA,Wang Y,Soriano VX,Martino DJ,Allen KJ,Ellis JA,Koplin JJ

更新日期：2019-09-01 00:00:00

abstract：:A study was undertaken to see whether the principal airborne fungi in the North-East Netherlands were also found to be the most reactive in skin testing. Atmospheric samples were taken weekly with the Andersen sampler, from April 1981, up to and including, June 1983. At the same time skin tests of 833 patients referre...

journal_title：Allergy

authors： Beaumont F,Kauffman HF,de Monchy JG,Sluiter HJ,de Vries K

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Immunotherapy with Hymenoptera venoms is highly effective but causes allergic side-effects frequently, especially when honeybee venom is used. Therefore, our objective was to investigate the effect of pretreatment with the antihistamine fexofenadine on the incidence of allergic side-effects during ultrarush ...

journal_title：Allergy

authors： Reimers A,Hari Y,Müller U

更新日期：2000-05-01 00:00:00

abstract：:Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti-allergic drug, on bronchoconstri...

journal_title：Allergy

authors： Kurashima K,Fujimura M,Saito M,Sakamoto S,Miyake Y,Nishi K,Matsuda T

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The reasons for the rise in asthma and allergies remain unclear. To identify risk or protective factors, it is essential to carry out longitudinal epidemiological studies, preferably birth cohort studies. In Europe, several birth cohort studies on asthma and atopic diseases have been initiated over the last ...

journal_title：Allergy

authors： Keil T,Kulig M,Simpson A,Custovic A,Wickman M,Kull I,Lødrup Carlsen KC,Carlsen KH,Smit HA,Wijga AH,Schmid S,Berg A,Bollrath C,Eller E,Bindslev-Jensen C,Halken S,Høst A,Heinrich J,Porta D,Forastiere F,Brunekreef B

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Intradermal skin testing of the clinically important antibiotics ciprofloxacin, clarithromycin, and rifampicin in the case of suspected allergies to antibiotics is poorly standardized. For clinical practice, standardized procedures and protocols are desired. METHODS:Fifteen healthy volunteers were tested wi...

journal_title：Allergy

authors： Brož P,Harr T,Hecking C,Grize L,Scherer K,Jaeger KA,Bircher AJ

更新日期：2012-05-01 00:00:00

abstract：:The aim of this systematic review was to summarize and assess the quality of asthma intervention health economic studies from 2002 to 2007, compare the study findings with clinical management guidelines, and suggest avenues for future improvement of asthma health economic studies. Forty of the 177 studies met our incl...

journal_title：Allergy

authors： Campbell JD,Spackman DE,Sullivan SD

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:CD40 and OX40 Ligand (OX40L) are cell-surface molecules expressed on airway smooth muscle (ASM) that can enhance inflammatory cell activation and survival. The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expres...

journal_title：Allergy

authors： Krimmer DI,Loseli M,Hughes JM,Oliver BG,Moir LM,Hunt NH,Black JL,Burgess JK

更新日期：2009-07-01 00:00:00