Abstract:
:In analogy with findings from animal experiments, people with low glutathione-peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of the 12 patients had very low or low GSH-Px activity and the frequency of low GSH-Px activity in this group was statistically significant (P less than 0.001) compared with the control material of age- and sex-matched healthy individuals. Our finding of lowered GSH-Px activity in patients with aspirin intolerance may indicate the involvement of hitherto unknown mechanisms in the pathogenesis of asthmatic disorders.
journal_name
Allergyjournal_title
Allergyauthors
Malmgren R,Unge G,Zetterström O,Theorell H,de Wahl Kdoi
10.1111/j.1398-9995.1986.tb00273.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
43-5issue
1eissn
0105-4538issn
1398-9995journal_volume
41pub_type
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