Lowered glutathione-peroxidase activity in asthmatic patients with food and aspirin intolerance.

Abstract:

:In analogy with findings from animal experiments, people with low glutathione-peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of the 12 patients had very low or low GSH-Px activity and the frequency of low GSH-Px activity in this group was statistically significant (P less than 0.001) compared with the control material of age- and sex-matched healthy individuals. Our finding of lowered GSH-Px activity in patients with aspirin intolerance may indicate the involvement of hitherto unknown mechanisms in the pathogenesis of asthmatic disorders.

journal_name

Allergy

journal_title

Allergy

authors

Malmgren R,Unge G,Zetterström O,Theorell H,de Wahl K

doi

10.1111/j.1398-9995.1986.tb00273.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

43-5

issue

1

eissn

0105-4538

issn

1398-9995

journal_volume

41

pub_type

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