A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy.

Abstract:

BACKGROUND:It has been suggested that human breast milk oligosaccharides play a role in the development of the immune system in infants, and may consequently inhibit the onset of allergy. A specific prebiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GOS/FOS) has been shown to reduce the incidence of atopic dermatitis (AD) at 6 months of age in infants at risk for allergy. AIM OF THE STUDY:This study was aimed to analyze the effect of GOS/FOS on the immune response in these infants. METHODS:In a double-blind randomized placebo-controlled study, infants received a hypoallergenic whey formula with either 8 g/l GOS/FOS in a 9 : 1 ratio (IMMUNOFORTIS) or 8 g/l maltodextrine (placebo) for 6 months. At 3 months of age, children were vaccinated with Hexavac against a.o. diphteria, tetanus, polio (DTP). At 6 months of age, plasma samples were collected from 84 infants (verum group n = 41, placebo group n = 43). Levels of total immunoglobulins (Ig) and of cow's milk protein (CMP-) and DTP-specific Ig were measured. RESULTS:GOS/FOS supplementation led to a significant reduction in the plasma level of total IgE, IgG1, IgG2 and IgG3, whereas no effect on IgG4 was observed. CMP-specific IgG1 was significantly decreased. DTP-specific Ig levels were not affected. CONCLUSIONS:This study shows that GOS/FOS supplementation induces a beneficial antibody profile. GOS/FOS reduces the total Ig response and modulates the immune response towards CMP, while leaving the response to vaccination intact. This suggests that oral GOS/FOS supplementation is a safe method to restrain the atopic march.

journal_name

Allergy

journal_title

Allergy

authors

van Hoffen E,Ruiter B,Faber J,M'Rabet L,Knol EF,Stahl B,Arslanoglu S,Moro G,Boehm G,Garssen J

doi

10.1111/j.1398-9995.2008.01765.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

484-7

issue

3

eissn

0105-4538

issn

1398-9995

pii

ALL1765

journal_volume

64

pub_type

杂志文章,随机对照试验

相关文献

ALLERGY文献大全
  • Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.

    abstract::Azelastine hydrochloride, chemically known as 1(2H)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepine-4-yl)-, monohydrochloride, is a novel, orally effective, long-acting, antiallergic/antiasthmatic agent. The ability of azelastine and selected antiallergic drugs to inhibit SRS-A (leukotriene)...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00331.x

    authors: Chand N,Nolan K,Diamantis W,Perhach JL Jr,Sofia RD

    更新日期:1986-09-01 00:00:00

  • Understanding the challenges faced by adolescents and young adults with allergic conditions: A systematic review.

    abstract:BACKGROUND:Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. METHODS:A systematic literature search was under...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14258

    authors: Vazquez-Ortiz M,Angier E,Blumchen K,Comberiati P,Duca B,DunnGalvin A,Gore C,Hox V,Jensen B,Pite H,Santos AF,Sanchez S,Alviani C,Garriga-Baraut T,Knibb R,Mortz CG,Gowland MH,Timmermans F,Roberts G

    更新日期:2020-08-01 00:00:00

  • Specificity of ELISA for IgG subclass antibodies against inhalant antigens in early childhood.

    abstract::ELISA is increasingly used to measure antibodies in new circumstances. Recently, it has been applied to the measurement of IgG subclass antibodies against common antigens in early childhood. These studies have raised concerns about the specificity of some of these assays. This paper details the results of experiments ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02093.x

    authors: Ruiz RG,Price JF,Kemeny DM

    更新日期:1994-10-01 00:00:00

  • Farm animal feeders: another group affected by cereal flour asthma.

    abstract::Asthma induced by cereal flour is a long recognized entity. We present studies of three patients affected by asthma related to exposure to cereal flour contained in animal formula feeds. Skin prick test performed with the formula feed components showed positive reactions to cereal flours (wheat, rye and barley) and ne...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00909.x

    authors: Valdivieso R,Pola J,Zapata C,Puyana J,Cuesta J,Martin C,Losada E

    更新日期:1988-08-01 00:00:00

  • COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper.

    abstract:BACKGROUND:The Coronavirus disease 2019 (COVID-19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14453

    authors: Pfaar O,Klimek L,Jutel M,Akdis CA,Bousquet J,Breiteneder H,Chinthrajah S,Diamant Z,Eiwegger T,Fokkens WJ,Fritsch HW,Nadeau KC,O'Hehir RE,O'Mahony L,Rief W,Sampath V,Schedlowski M,Torres M,Traidl-Hoffmann C,Wang DY,

    更新日期:2020-06-12 00:00:00

  • Paranasal sinus pathology in allergic and non-allergic respiratory tract diseases.

    abstract::Two hundred and seventy patients with asthma and/or rhinitis (162 or 60% allergic, 108 or 40% non-allergic) were studied for sinus pathology by means of standard X-rays and tomograms. Sinus pathology was defined as abnormal sinus X-rays, either on standard or tomography. Fifty-four percent of the X-rays were classifie...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00306.x

    authors: De Cleyn KM,Kersschot EA,De Clerck LS,Ortmanns PM,De Schepper AM,Van Bever HP,Stevens WJ

    更新日期:1986-07-01 00:00:00

  • Priming and inducing effects of interleukin-3 on histamine release from cord-blood basophils.

    abstract::The effect of interleukin-3 (IL-3) on histamine release from cord and adult blood basophils were evaluated. Leukocyte suspensions, obtained from adult patients with respiratory allergy (n = 15), normal adult subjects (n = 15), and neonates with (n = 15) and without (n = 19) atopic disposition, were stimulated with ant...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb02419.x

    authors: Miadonna A,Salmaso C,Marco MP,Pugni L,Milazzo N,Tedeschi A,Marini A

    更新日期:1997-10-01 00:00:00

  • Mercurochrome allergy. Immediate and delayed hypersensitivity.

    abstract::We describe eight patients suffering from Mercurochrome allergy. Patch and prick tests were carried out with the following organic and inorganic mercury compounds: thimerosal, Mercurochrome, phenylmercuric acetate, phenylmercuric nitrate, metallic mercury, and mercuric chloride, and with sodium fluorescein. Two patien...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb00190.x

    authors: Galindo PA,Feo F,García R,Gómez E,Borja J,Fernández F

    更新日期:1997-11-01 00:00:00

  • Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps.

    abstract:BACKGROUND:The role of myeloid and plasmacytoid dendritic cells and its consequences for the T(H)2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP(+)) should be detailed. METHODS:In 18 CRS patients without nasal polyps (CRSNP(-)), 35 CRSNP(+) patients and 22 patients with nasal structural abnormalities w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.02174.x

    authors: Kirsche H,Niederführ A,Deutschle T,Fuchs C,Riechelmann H

    更新日期:2010-01-01 00:00:00

  • Urban/rural differences in diet and atopy in South Africa.

    abstract:BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1398-9995.2008.01627.x

    authors: Hooper R,Calvert J,Thompson RL,Deetlefs ME,Burney P

    更新日期:2008-04-01 00:00:00

  • House-dust mites and mattresses.

    abstract:BACKGROUND:Despite considerable efforts to develop anti dust mite strategies, surprisingly few studies have evaluated the allergen content in different types of mattresses in everyday use. This study investigated the presence of mite feces (an indicator of mite allergens) in foam and spring mattresses. METHODS:The hom...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23433.x

    authors: Schei MA,Hessen JO,Lund E

    更新日期:2002-06-01 00:00:00

  • Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ.

    abstract:BACKGROUND:Several epidemiologic studies in the United States and Europe have linked Alternaria sensitivity to both persistence and severity of asthma. In this study, we examined T cell responses and HLA class II alleles in children with moderate-severe asthma. METHODS:Ninety-six children with moderate-severe asthma w...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02382.x

    authors: Knutsen AP,Vijay HM,Kumar V,Kariuki B,Santiago LA,Graff R,Wofford JD,Shah MR

    更新日期:2010-11-01 00:00:00

  • Anamnestic data in allergic rhinitis.

    abstract::In a study of 770 patients with allergic rhinitis, anamnestic data were collected by means of a questionnaire. 484 (63%) of the patients were women and 286 (37%) men. 45.5% of the patients had perennial symptoms, 33.5% had seasonal symptoms only, and 21% had predominantly seasonal but also some perennial symptoms. Mor...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1982.tb02317.x

    authors: Binder E,Holopainen E,Malmberg H,Salo O

    更新日期:1982-08-01 00:00:00

  • Prevalence of lysozyme sensitization in an egg-allergic population.

    abstract::An egg protein, lysozyme, is a still unlabeled additive currently used in cheese preparation. Furthermore, the WHO-FAO committee considers it innocuous. However, 31% of children and 8% of adults with food allergies are allergic to eggs. This work aimed to determine the percentage of patients sensitized to lysozyme fro...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb00980.x

    authors: Frémont S,Kanny G,Nicolas JP,Moneret-Vautrin DA

    更新日期:1997-02-01 00:00:00

  • Detection of specific IgE antibodies towards cat flea (Ctenocephalides felis felis) in patients with suspected cat allergy.

    abstract::Cat flea sensitivity is considered one of the most important skin diseases in cats and dogs. Cat fleas, however, are also a growing allergen problem for humans. Cat flea-specific IgE antibodies were studied in serum samples from 70 patients with suspected cat allergy, using RAST-based techniques and the nitrocellulose...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb02196.x

    authors: Rolfsen W,Schröder H,Tibell C,Tibell M

    更新日期:1987-04-01 00:00:00

  • Tomato allergy in children and young adults: cross-reactivity with latex and potato.

    abstract:BACKGROUND:Several studies have shown that allergy to natural rubber latex is associated with cross-reactivity to certain foods such as tomato and potato. The objective was to investigate the clinical and immunologic differences between a group of patients with clinical allergy to tomato and latex and another which had...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.00279.x

    authors: Reche M,Pascual CY,Vicente J,Caballero T,Martín-Muñoz F,Sanchez S,Martín-Esteban M

    更新日期:2001-12-01 00:00:00

  • Helminths can protect themselves against rejection inhibiting hostile respiratory allergy symptoms.

    abstract::The ability of common environmental allergens to stimulate IgE responses and thus to produce allergic diseases has tended to overshadow the fact that helminthic parasites are possibly the most potent inducers of this immunoglobulin that exists in nature. Although it has been well established that during these infectio...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2006.00983.x

    authors: Mingomataj EC,Xhixha F,Gjata E

    更新日期:2006-04-01 00:00:00

  • Contact allergy to budesonide contained in a nasal spray.

    abstract::We describe a case of contact allergic sensitization to budesonide in a nasal spray used in the treatment of allergic rhinitis. No cross-sensitivity to other topical corticosteroids was found. ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb02392.x

    authors: Sastre J,Ibañez MD

    更新日期:1992-12-01 00:00:00

  • Quantification of a major bovine allergen by a two-site immunometric assay based on monoclonal antibodies.

    abstract::A two-site immunometric assay based on monoclonal antibodies (mAb) was developed for the measurement of a 20-kDa major allergen of cow. The sensitivity of this assay was (BDA20) 1 ng/ml. It was used to measure airborne allergen concentrations in 10 Finnish cowsheds. The mean concentration of the BDA20 measured at two ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb02091.x

    authors: Ylönen J,Virtanen T,Rytkönen M,Mäntyjärvi R

    更新日期:1994-10-01 00:00:00

  • IgE autoantibodies in atopic dermatitis--occurrence of different antibodies against the CH3 and the CH4 epitopes of IgE.

    abstract::Levels of "free" anti-IgE autoantibodies and IgE/anti-IgE immune complexes were measured in the sera of patients with atopic dermatitis before and after treatment, psoriasis patients, and nonatopic controls. In this measurement, we used two monoclonal antibodies with distinct in vitro functions (LE 27, BSW 17), direct...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb01141.x

    authors: Czech W,Stadler BM,Schôpf E,Kapp A

    更新日期:1995-03-01 00:00:00

  • Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.

    abstract::The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics and a randomized, d...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1982.tb01884.x

    authors: Svedmyr K,Mellstrand T,Svedmyr N

    更新日期:1982-02-01 00:00:00

  • The structural basis of allergenicity: recombinant DNA-based strategies for the study of allergens.

    abstract::The use of recombinant DNA techniques for the study of allergenicity of proteins is a viable, and in many ways a preferred, alternative to the traditional procedures of protein purification, digestion and analysis of peptides for both allergenicity and amino acid sequence. The process of protein purification can be di...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1989.tb02230.x

    authors: Baldo BA,Donovan GR

    更新日期:1989-02-01 00:00:00

  • Ingestive and inhalative allergy to the mushroom Boletus edulis.

    abstract::This is the first report on inhalative and ingestive allergy to the common edible mushroom Boletus edulis (Be) (English, edible boletus; German, Steinpilz; French, bolet; Italian, porcino or boleto) belonging to the class Basidiomycetes. Four cases observed in our allergy unit are presented, showing different clinical...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb01232.x

    authors: Torricelli R,Johansson SG,Wüthrich B

    更新日期:1997-07-01 00:00:00

  • Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.

    abstract:BACKGROUND:Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic. METHODS:Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Ev...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2010.02412.x

    authors: Matsui EC,Sampson HA,Bahnson HT,Gruchalla RS,Pongracic JA,Teach SJ,Gergen PJ,Bloomberg GR,Chmiel JF,Liu AH,Kattan M,Sorkness CA,Steinbach SF,Story RE,Visness CM,Inner-city Asthma Consortium.

    更新日期:2010-11-01 00:00:00

  • The burden of atopy and asthma in children.

    abstract:BACKGROUND:There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS:MEDLINE was searched for articles re...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2004.00563.x

    authors: O'Connell EJ

    更新日期:2004-08-01 00:00:00

  • Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency.

    abstract:BACKGROUND:Hereditary angioedema (HAE), type I and II, is an autosomal dominant disease with deficiency of functional C1 inhibitor protein causing episodic swellings of skin, mucosa and viscera. HAE is a genetically heterogeneous disease with more than 200 different mutations in the SERPING1 gene. A genotype-phenotype ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02456.x

    authors: Bygum A,Fagerberg CR,Ponard D,Monnier N,Lunardi J,Drouet C

    更新日期:2011-01-01 00:00:00

  • Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.

    abstract::Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1-receptor antagonist, 0.05% mequitazine eye-drops, was tested in a double-blind ran...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1997.tb01028.x

    authors: Persi L,Dupin O,Arnaud B,Trinquand C,Michel FB,Bousquet J

    更新日期:1997-04-01 00:00:00

  • Allergens in house-dust samples in Germany: results of an East-West German comparison.

    abstract::The background of this study is the finding of several studies that the frequency of respiratory allergies was significantly higher in the former West Germany than the former East Germany. The present study investigated the levels of allergens of house-dust mite (Der p 1 and Der f 1), cat (Fel d 1), and cockroach (Bla...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00196.x

    authors: Fahlbusch B,Heinrich J,Gross I,Jäger L,Richter K,Wichmann HE

    更新日期:1999-11-01 00:00:00

  • Markers for eosinophils and T-lymphocytes as predictors of late asthmatic response.

    abstract::Bronchial allergen challenge was performed on 12 allergic asthmatics during a stable phase of their disease. After resolution of the immediate bronchial response, fractional lung lavage was performed twice, two and 24 h post-challenge. The recovery of eosinophils, eosinophil cationic protein (ECP), eosinophil chemotac...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1993.tb04708.x

    authors: Schmekel B,Venge P

    更新日期:1993-01-01 00:00:00

  • The influence of early environmental exposures on immune development and subsequent risk of allergic disease.

    abstract::Environmental exposures in pregnancy and the early postnatal period affect early immune development. Early immune function and future allergy susceptibility appear to result from a combination of maternal phenotype, infant genotype, and environmental exposures in utero that affect early gene expression. Furthermore, e...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02620.x

    authors: Prescott SL

    更新日期:2011-07-01 00:00:00