The structural basis of allergenicity: recombinant DNA-based strategies for the study of allergens.

abstract：BACKGROUND:  Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses and is frequently divided into polypoid CRS (CRSwNP) and nonpolypoid CRS (CRSsNP). However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the s...

journal_title：Allergy

authors： Keswani A,Chustz RT,Suh L,Carter R,Peters AT,Tan BK,Chandra R,Kim SH,Azam T,Dinarello CA,Kern RC,Schleimer RP,Kato A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway inflammation is unknown. OBJECTIVES:This study investigated whether allergen-induced airway inflammation involves an impaired local AM response. METHO...

journal_title：Allergy

authors： Hagner S,Welz H,Kicic A,Alrifai M,Marsh LM,Sutanto EN,Ling KM,Stick SM,Müller B,Weissmann N,Renz H

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Group 2 innate lymphoid cells (ILC2s) were closely associated with asthma. However, there were no perspective studies about the effects of glucocorticoid on ILC2s in asthma patients. Our objective was to perform a perspective study and evaluate the ILC2 activity after glucocorticoid therapy in asthma patient...

journal_title：Allergy

authors： Yu QN,Guo YB,Li X,Li CL,Tan WP,Fan XL,Qin ZL,Chen D,Wen WP,Zheng SG,Fu QL

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Strategies to prevent children from developing allergy have been elaborated on the basis of state-of-the-art reviews of the scientific literature regarding pets and allergies, building dampness and health, and building ventilation and health. A similar multidisciplinary review of infant feeding mode in relat...

journal_title：Allergy

authors： van Odijk J,Kull I,Borres MP,Brandtzaeg P,Edberg U,Hanson LA,Høst A,Kuitunen M,Olsen SF,Skerfving S,Sundell J,Wille S

更新日期：2003-09-01 00:00:00

abstract：:Sublingual immunotherapy has been shown in some clinical studies to modulate allergen-specific antibody responses [with a decrease in the immunoglobulin E/immunoglobulin G4 (IgE/IgG4) ratio] and to reduce the recruitment and activation of proinflammatory cells in target mucosa. Whereas a central paradigm for successfu...

journal_title：Allergy

authors： Moingeon P,Batard T,Fadel R,Frati F,Sieber J,Van Overtvelt L

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The prevalence of self-reported symptoms of allergic rhinitis is increasing in many countries, but the reasons for this trend are not well understood. Data from a 6-year follow-up study of a population sample of children and adolescents (n=408), aged 7-17 years at enrolment in 1986, were analyzed to investig...

journal_title：Allergy

authors： Ulrik CS,von Linstow ML,Backer V

更新日期：2000-11-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosano...

journal_title：Allergy

authors： Pezato R,Świerczyńska-Krępa M,Niżankowska-Mogilnicka E,Derycke L,Bachert C,Pérez-Novo CA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Whereas recent studies underlie the fundamental importance of the CC chemokine receptor 3 (CCR3) for the recruitment of eosinophils in allergic diseases, controversial data exist about the relevance of CCR1 on eosinophils. Therefore, the purpose of this study was to investigate the expression and regulation ...

journal_title：Allergy

authors： Elsner J,Dulkys Y,Gupta S,Escher SE,Forssmann WG,Kapp A,Forssmann U

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:This paper reports a study on the concentrations of the pro-inflammatory cytokines IL-18 and IL-1beta in nasal secretions of allergic rhinitis patients in relation to ECP and nasal symptoms. METHODS:We measured IL-18 and IL-1beta concentrations using ELISA, and eosinophilic cationic protein (ECP) using the ...

journal_title：Allergy

authors： Verhaeghe B,Gevaert P,Holtappels G,Lukat KF,Lange B,Van Cauwenberge P,Bachert C

更新日期：2002-09-01 00:00:00

abstract：:This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...

journal_title：Allergy

authors： Savolainen J,Kortekangas-Savolainen O,Nermes M,Viander M,Koivikko A,Kalimo K,Terho EO

更新日期：1998-05-01 00:00:00

abstract：:Drug-induced erythema multiforme is reported with many antimicrobial and antipyretic medications. We present one patient who experienced erythema multiforme and urticaria after administration of pyrazinamide for treatment of cutaneous tuberculosis. The side-effects of pyrazinamide include hepatic or dermatologic disor...

journal_title：Allergy

authors： Perdu D,Lavaud F,Prévost A,Deschamps F,Cambie MP,Bongrain E,Barhoum K,Kalis B

更新日期：1996-05-01 00:00:00

abstract：:Since the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosapros...

journal_title：Allergy

authors： Canonica GW,Ciprandi G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis is commonly divided into seasonal and perennial rhinitis. The recent Allergic Rhinitis and its Impact on Asthma (ARIA) workshop proposes to replace these terms by intermittent vs persistent rhinitis. METHODS:In order to test the new ARIA classification against the classical one used in med...

journal_title：Allergy

authors： Demoly P,Allaert FA,Lecasble M,Bousquet J,PRAGMA.

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Differential leukocyte counts are of proven clinical value, but information about basophil counts in normal and disease conditions is scarce although basophils are regarded as key effector cells in allergy. AIMS:To establish and validate flowcytometric methods for counting basophils in peripheral human bloo...

journal_title：Allergy

authors： Ducrest S,Meier F,Tschopp C,Pavlovic R,Dahinden CA

更新日期：2005-11-01 00:00:00

abstract：:A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot t...

journal_title：Allergy

authors： Taudorf E,Bundgaard A,Fagerström PO,Weeke E,Weeke B

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. METHODS:FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evalu...

journal_title：Allergy

authors： Schuttelaar ML,Kerkhof M,Jonkman MF,Koppelman GH,Brunekreef B,de Jongste JC,Wijga A,McLean WH,Postma DS

更新日期：2009-12-01 00:00:00

abstract：:The estimation of exposure to molds and their products in the indoor environment, which may lead to the occurrence of allergies or respiratory complaints, by means of enumeration of viable parts is inadequate. Therefore, other methods must be developed. When grown under various circumstances (22 degrees C and 30 degre...

journal_title：Allergy

authors： Wijnands LM,Deisz WD,van Leusden FM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...

journal_title：Allergy

authors： Savilahti R,Uitti J,Roto P,Laippala P,Husman T

更新日期：2001-02-01 00:00:00

abstract：:In a double blind study, alcohol/onion extract (5% ethanol) was injected simultaneously with 20 IU and 200 IU rabbit anti-human-IgE intradermally in 12 adult volunteers (6 atopics, 6 non-atopics). Diameters of wheals and flares were measured 10 min after and compared with control sites challenged with 20 IU and 200 IU...

journal_title：Allergy

authors： Dorsch W,Ring J

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk of the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common conclusion. We investigated ...

journal_title：Allergy

authors： Yoon SH,Lee SY,Kang HR,Kim JY,Hahn S,Park CM,Chang YS,Goo JM,Cho SH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Signal transducer and activator of transcription 1 (STAT1), an intracellular signal transducer and activator of transcription centrally involved in many inflammatory pathways, was recently suggested to play an important role in allergy related immune responses. AIM:Thus, we investigated the effect of polymo...

journal_title：Allergy

authors： Pinto LA,Steudemann L,Depner M,Klopp N,Illig T,Weiland SK,von Mutius E,Kabesch M

更新日期：2007-12-01 00:00:00

abstract：:Asthma is a generalized term that describes a scope of distinct pathologic phenotypes of variable severity, which share a common complication of reversible airflow obstruction. Asthma is estimated to affect almost 400 million people worldwide, and nearly ten percent of asthmatics have what is considered "severe" disea...

journal_title：Allergy

authors： Perkins TN,Donnell ML,Oury TD

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality-of-life charact...

journal_title：Allergy

authors： Valero A,Quirce S,Dávila I,Delgado J,Domínguez-Ortega J

更新日期：2017-09-01 00:00:00

abstract：:The presence of indoor allergens in Finnish homes was studied for the first time. Dust samples (n = 30) were collected by vacuuming a 1 m2 area from a living-room carpet in 30 apartments divided into three groups: homes with cats (n = 10), homes with dogs (n = 10), and homes without pets (n = 10). The levels of major ...

journal_title：Allergy

authors： Raunio P,Pasanen AL,Reiman M,Virtanen T

更新日期：1998-02-01 00:00:00

abstract：:Inhalation and nasal aspirin challenge has been investigated in asthma patients with co-existing rhinitis. Eight of 39 asthma patients were diagnosed as aspirin-sensitive on the basis of inhalation challenge. Seven aspirin-sensitive asthmatics were subjected to nasal aspirin provocation. During nasal challenge, all se...

journal_title：Allergy

authors： Pawlowicz A,Williams WR,Davies BH

更新日期：1991-08-01 00:00:00

abstract：:Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is wid...

journal_title：Allergy

authors： Ramirez LF,Pereira A,Chiriac AM,Bonnet-Boyer MC,Demoly P

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Fluorescence-labeled MHC class II/peptide tetramer complexes are considered as optimal tools to characterize allergen-specific CD4(+) T cells, but this technique is restricted to frequently expressed HLA class II molecules and knowledge of immunodominant epitopes. In contrast, allergen-stimulated proliferati...

journal_title：Allergy

authors： Van Hemelen D,Mahler V,Fischer G,Fae I,Reichl-Leb V,Pickl W,Jutel M,Smolinska S,Ebner C,Bohle B,Jahn-Schmid B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Partial mattress encasing was found to be effective in reducing exposure to mite allergen in our previous investigation. We aimed to compare the short-term efficacy of partial and complete mattress encasing and to study mite-allergen levels within these mattresses. METHODS:Thirty-one mattresses with high mi...

journal_title：Allergy

authors： Vichyanond P,Uthaisangsook S,Ruangruk S,Malainual N

更新日期：1999-07-01 00:00:00

abstract：:Indoor allergens are likely to be direct environmental causes of asthma and mite exposure, and sensitization is the most important environmental risk factor for childhood asthma in temperate zones. Analagous to occupational asthma, allergen avoidance in asthmatic children sensitized and exposed to mite allergens is as...

journal_title：Allergy

authors： Boner A,Pescollderungg L,Silverman M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Intradermal skin testing of the clinically important antibiotics ciprofloxacin, clarithromycin, and rifampicin in the case of suspected allergies to antibiotics is poorly standardized. For clinical practice, standardized procedures and protocols are desired. METHODS:Fifteen healthy volunteers were tested wi...

journal_title：Allergy

authors： Brož P,Harr T,Hecking C,Grize L,Scherer K,Jaeger KA,Bircher AJ

更新日期：2012-05-01 00:00:00