Abstract:
:A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot tablets 7.5 mg twice a day compared to terbutaline tablets 5 mg three times a day. Patients suffering from perennial asthma and with daily requirement of asthma medicine were accepted for the study. The trial was a double-blind cross-over, double dummy and randomized. The tablets were given in two consecutive periods of 7 day's duration each. The effect of terbutaline depot tablets was equal to the effect of the ordinary terbutaline tablets. The indication for using depot tablets in the basic treatment of bronchial asthma is a better patient compliance due to medication twice a day. Furthermore in patients with unstable bronchial asthma and in patients with morning dips in PEF the more stable plasma concentration may perhaps keep the patients in a more steady state.
journal_name
Allergyjournal_title
Allergyauthors
Taudorf E,Bundgaard A,Fagerström PO,Weeke E,Weeke Bdoi
10.1111/j.1398-9995.1981.tb01861.xsubject
Has Abstractpub_date
1981-10-01 00:00:00pages
495-500issue
7eissn
0105-4538issn
1398-9995journal_volume
36pub_type
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