Terbutaline depot tablets in asthma. A clinical evaluation.

Abstract:

:A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot tablets 7.5 mg twice a day compared to terbutaline tablets 5 mg three times a day. Patients suffering from perennial asthma and with daily requirement of asthma medicine were accepted for the study. The trial was a double-blind cross-over, double dummy and randomized. The tablets were given in two consecutive periods of 7 day's duration each. The effect of terbutaline depot tablets was equal to the effect of the ordinary terbutaline tablets. The indication for using depot tablets in the basic treatment of bronchial asthma is a better patient compliance due to medication twice a day. Furthermore in patients with unstable bronchial asthma and in patients with morning dips in PEF the more stable plasma concentration may perhaps keep the patients in a more steady state.

journal_name

Allergy

journal_title

Allergy

authors

Taudorf E,Bundgaard A,Fagerström PO,Weeke E,Weeke B

doi

10.1111/j.1398-9995.1981.tb01861.x

subject

Has Abstract

pub_date

1981-10-01 00:00:00

pages

495-500

issue

7

eissn

0105-4538

issn

1398-9995

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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