Occupational conjunctivitis associated with type IV allergy to methacrylates.


:On rare occasions, exposure to methacrylates (MAs) may induce mucosal symptoms. Three patients, two dental laboratory workers and one hearing aid laboratory worker, are presented. All three had allergic contact dermatitis from MAs which disappeared after avoidance of contact with uncured MA compounds. Two of the patients, the dental laboratory assistant and the hearing aid worker, had also developed symptoms of conjunctivitis. Both were exposed to chemically curable and light-curable MAs. The association between their conjunctivitis and type IV allergy to MAs was supported by the following observations: 1) sensitization to several MAs including methylMA, 2-hydroxyethylMA, ethyleneglycol diMA, triethyleneglycoldiMA, tetrahydrofurfuryldiMA, and 1,4-butanedioldiMA, as well as to pentaerythritol triacrylate; 2) simultaneous appearance of their eye symptoms and allergic contact dermatitis; 3) high exposure to MAs because of disturbances of ventilation; 4) disappearance of the eye symptoms during holidays; and 5) opthalmologist's findings of follicular conjunctivitis with some papillae, eosinophilia, and lymphocytosis in conjunctival scrapings corresponding to allergic contact conjunctivitis. In addition, the activation of eosinophils in the conjunctival scrapings was demonstrated with the monoclonal antibody technique, and an elevated level of eosinophilic cationic protein was found in the tear fluid. Our cases suggest that conjunctivitis may be caused by type IV allergy to MAs, although type I allergy (even though prick tests were negative), other hypersensitivity mechanisms, or irritation cannot be excluded. 4H-Gloves seem to give adequate hand protection even to allergic patients. More attention should be paid to ventilation systems if MA exposure occurs. In some cases, patients with eye symptoms need to be patch tested.






Estlander T,Kanerva L,Kari O,Jolanki R,Mölsä K




Has Abstract


1996-01-01 00:00:00














  • Food-induced cutaneous adverse reactions.

    abstract::The skin is the most frequently affected target organ in allergy or intolerance of food and food additives. The most common manifestation is acute urticaria (with or without angioedema), accounting for 40-60% of patients with IgE-mediated food allergy, whereas food additives rather aggravate chronic urticaria (intoler...


    pub_type: 杂志文章,评审


    authors: Wüthrich B

    更新日期:1998-01-01 00:00:00

  • Blocking activity of mite-specific IgG antibodies studied by skin tests.

    abstract::The aim of the study was to determine whether IgG antibodies from patients on specific immunotherapy could inhibit skin test reactivity of allergens when mixed with them prior to testing. In a preliminary double-blind study, mite extracts were incubated with glycero-saline solution or non-specific IgG and used in test...


    pub_type: 临床试验,杂志文章


    authors: Pecquet C,Murrieta M,Michelen V,Leynadier F,Dry J,Allary M,Fabre G,Saint-Blancard J

    更新日期:1989-08-01 00:00:00

  • Immunology of atopic eczema: overcoming the Th1/Th2 paradigm.

    abstract::Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely affects quality of life of patients and their families, and causes high socioeconomic costs. The pathogenesis of AE is complex. While initial studies suggested a Th2 deviation as primary reason for the disease, numerous studies ad...


    pub_type: 杂志文章,评审


    authors: Eyerich K,Novak N

    更新日期:2013-08-01 00:00:00

  • Extent, patterns, and burden of uncontrolled disease in severe or difficult-to-treat asthma.

    abstract:BACKGROUND:Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. METHODS:Baseline pati...


    pub_type: 杂志文章,多中心研究


    authors: Sullivan SD,Rasouliyan L,Russo PA,Kamath T,Chipps BE,TENOR Study Group.

    更新日期:2007-02-01 00:00:00

  • Immunostimulatory DNA-based therapeutics for experimental and clinical allergy.

    abstract::Although allergen immunotherapy (IT) has been shown to modulate allergic hypersensitivities, its efficacy is limited. Recently, in various models of experimental allergy, a number of reagents which we have termed immunostimulatory DNA-based therapeutics have proven highly effective in both the prevention and reversal ...


    pub_type: 杂志文章,评审


    authors: Horner AA,Takabaysahi K,Zubeldia JM,Raz E

    更新日期:2002-01-01 00:00:00

  • Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model.

    abstract:BACKGROUND:In high-risk populations, allergen-specific prophylaxis could protect from sensitization and subsequent development of allergic disease. However, such treatment might itself induce sensitization and allergies, thus requiring hypoallergenic vaccine formulations. We here characterized the preventive potential ...


    pub_type: 杂志文章


    authors: Kratzer B,Köhler C,Hofer S,Smole U,Trapin D,Iturri J,Pum D,Kienzl P,Elbe-Bürger A,Gattinger P,Mittermann I,Linhart B,Gadermaier G,Jahn-Schmid B,Neunkirchner A,Valenta R,Pickl WF

    更新日期:2019-02-01 00:00:00

  • Cytodestructive mechanisms provoked by food antigens. II. Antibody-dependent, allergic autocytotoxicity.

    abstract::Antibody-dependent, allergic autocytotoxicity (ACT) is an in vitro process through which WBC from patients and/or controls, passively sensitized with RAST positive serum, are damaged in the presence of corresponding food antigens. Studies among 13 patients, sensitive to cow milk, corn and wheat, and 13 asymptomatic co...


    pub_type: 杂志文章


    authors: Podleski WK

    更新日期:1985-04-01 00:00:00

  • The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease.

    abstract::Asthma is a generalized term that describes a scope of distinct pathologic phenotypes of variable severity, which share a common complication of reversible airflow obstruction. Asthma is estimated to affect almost 400 million people worldwide, and nearly ten percent of asthmatics have what is considered "severe" disea...


    pub_type: 杂志文章,评审


    authors: Perkins TN,Donnell ML,Oury TD

    更新日期:2020-09-25 00:00:00

  • Mercurochrome allergy. Immediate and delayed hypersensitivity.

    abstract::We describe eight patients suffering from Mercurochrome allergy. Patch and prick tests were carried out with the following organic and inorganic mercury compounds: thimerosal, Mercurochrome, phenylmercuric acetate, phenylmercuric nitrate, metallic mercury, and mercuric chloride, and with sodium fluorescein. Two patien...


    pub_type: 杂志文章


    authors: Galindo PA,Feo F,García R,Gómez E,Borja J,Fernández F

    更新日期:1997-11-01 00:00:00

  • Biological assays for interleukin 1 detection. Comparison of human T lymphocyte, murine thymocyte and NOB-1 assays.

    abstract::Various biological assays are used for qualitative and quantitative measurements of interleukin 1 (IL-1) in supernatants from cell cultures. The purpose of the present study was to compare the specificity and variability of three cellular IL-1 bioassays: the PHA co-stimulatory human T lymphocyte proliferation assay, t...


    pub_type: 杂志文章


    authors: Remvig L,Vibe-Petersen J,Svenson M,Enk C,Bendtzen K

    更新日期:1991-01-01 00:00:00

  • Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

    abstract:BACKGROUND:Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM)...


    pub_type: 杂志文章


    authors: Niedoszytko M,Bruinenberg M,van Doormaal JJ,de Monchy JG,Nedoszytko B,Koppelman GH,Nawijn MC,Wijmenga C,Jassem E,Elberink JN

    更新日期:2011-05-01 00:00:00

  • Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN.

    abstract::This update aimed to review the new evidence available to support or refute prior Allergic Rhinitis and its Impact on Asthma (ARIA) statements. A Medline search of publications between 2000 and 2005 was conducted, with articles selected by experts. New evidence supports previous ARIA statements, such as: (i) allergic ...


    pub_type: 杂志文章,评审


    authors: Cruz AA,Popov T,Pawankar R,Annesi-Maesano I,Fokkens W,Kemp J,Ohta K,Price D,Bousquet J,ARIA Initiative Scientific Committee.

    更新日期:2007-01-01 00:00:00

  • Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015.

    abstract::MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale ...


    pub_type: 杂志文章,评审


    authors: Bousquet J,Anto JM,Akdis M,Auffray C,Keil T,Momas I,Postma DS,Valenta R,Wickman M,Cambon-Thomsen A,Haahtela T,Lambrecht BN,Lodrup Carlsen KC,Koppelman GH,Sunyer J,Zuberbier T,Annesi-Maesano I,Arno A,Bindslev-Jensen C

    更新日期:2016-11-01 00:00:00

  • Measurement of natural rubber latex allergen levels in medical gloves by allergen-specific IgE-ELISA inhibition, RAST inhibition, and skin prick test.

    abstract::Exposure to natural rubber latex (NRL) medical gloves poses risks to patients sensitized to NRL and to users of protective gloves. Previous studies have shown that extractable allergen levels of the gloves vary widely. Since most of the available laboratory methods of NRL allergen measurement lack adequate validation,...


    pub_type: 杂志文章


    authors: Palosuo T,Mäkinen-Kiljunen S,Alenius H,Reunala T,Yip E,Turjanmaa K

    更新日期:1998-01-01 00:00:00

  • Respiratory symptoms in ispaghula-allergic nurses after oral challenge with ispaghula suspension.

    abstract::Ispaghula powder, which is used as a component in bulk laxatives, is known to induce allergic reactions when inhaled by occupationally exposed persons. We have tested whether nurses sensitized by inhalation could get allergic symptoms when challenged by eating ispaghula. Of six nurses tested, all developed symptoms fr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Machado L,Stålenheim G

    更新日期:1984-01-01 00:00:00

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    abstract::In vitro challenge of peripheral white blood cells (WBC) from 62 food sensitive patients and 22 asymptomatic control individuals was performed using standardized extract of cow milk, corn and wheat. 81% of the patients reacted at least toward one food antigen, showing disintegration of WBC, as measured by trypan blue ...


    pub_type: 杂志文章


    authors: Podleski WK

    更新日期:1985-04-01 00:00:00

  • Effects of BCG revaccination on asthma.

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    pub_type: 临床试验,杂志文章


    authors: Choi IS,Koh YI

    更新日期:2003-11-01 00:00:00

  • Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin.

    abstract:BACKGROUND:Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible in pediatric populations. Tape strips are an emerging, minimally invasive alternative, but global transcriptomic profiling in early pediatric AD is lacking. We aimed t...


    pub_type: 杂志文章


    authors: Pavel AB,Renert-Yuval Y,Wu J,Del Duca E,Diaz A,Lefferdink R,Fang MM,Canter T,Rangel SM,Zhang N,Krueger JG,Paller AS,Guttman-Yassky E

    更新日期:2021-01-01 00:00:00

  • The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis.

    abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...


    pub_type: 杂志文章


    authors: Hu Y,Matsumoto Y,Dogru M,Okada N,Igarashi A,Fukagawa K,Tsubota K,Fujishima H

    更新日期:2007-08-01 00:00:00

  • Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.

    abstract::Six children and six adults were given a single dose of a sustained release theophylline preparation (Nuelin Retard) after an overnight fast and later after a standardized breakfast. Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food. ...


    pub_type: 杂志文章


    authors: Pedersen S,Moeller-Petersen J

    更新日期:1982-10-01 00:00:00

  • Health economics of asthma: assessing the value of asthma interventions.

    abstract::The aim of this systematic review was to summarize and assess the quality of asthma intervention health economic studies from 2002 to 2007, compare the study findings with clinical management guidelines, and suggest avenues for future improvement of asthma health economic studies. Forty of the 177 studies met our incl...


    pub_type: 杂志文章,评审


    authors: Campbell JD,Spackman DE,Sullivan SD

    更新日期:2008-12-01 00:00:00

  • Role of comorbid conditions in asthma hospitalizations in the south of France.

    abstract:BACKGROUND:Reasons for asthma hospitalizations are dynamic and complex. Comorbid conditions are important contributors to most chronic diseases today. We aim to characterize and describe risk factors associated with hospitalizations due to asthma in the Languedoc-Roussillon region (France) in 2009. METHODS:Programme d...


    pub_type: 杂志文章


    authors: Aubas C,Bourdin A,Aubas P,Gamez AS,Halimi L,Vachier I,Malafaye N,Chanez P,Molinari N

    更新日期:2013-01-01 00:00:00

  • Longitudinal evaluation of bone mass in asthmatic children treated with inhaled beclomethasone dipropionate or cromolyn sodium.

    abstract::Inhaled corticosteroids are recommended as first-line therapy in patients with moderate to severe asthma. The use of these agents in the milder form of asthma is controversial because of their potential adverse effects, especially in growing children. We investigated 49 asthmatic children (38 treated with beclomethaso...


    pub_type: 杂志文章


    authors: Martinati LC,Bertoldo F,Gasperi E,Fortunati P,Lo Cascio V,Boner AL

    更新日期:1998-07-01 00:00:00

  • Newly appreciated roles for basophils in allergy and protective immunity.

    abstract::Basophils are evolutionarily conserved in many animal species, in spite of the fact that they account for <1% of peripheral blood leukocyte. This suggests that basophils have an indispensable and nonredundant role in vivo, even though they show some phenotypic similarity with tissue-resident mast cells. However, their...


    pub_type: 杂志文章,评审


    authors: Karasuyama H,Obata K,Wada T,Tsujimura Y,Mukai K

    更新日期:2011-09-01 00:00:00

  • Four-year stability of Der p I in house dust under simulated domestic conditions in vitro.

    abstract::For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...


    pub_type: 杂志文章


    authors: Kort HS,Kniest FM

    更新日期:1994-02-01 00:00:00

  • Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines.

    abstract:BACKGROUND:The worldwide increasing incidence of allergic diseases requires the development of new, efficient vaccination strategies, the only curative treatment with a long-lasting effect. Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time. METHODS:We engineered m...


    pub_type: 杂志文章


    authors: Crameri R,Flückiger S,Daigle I,Kündig T,Rhyner C

    更新日期:2007-02-01 00:00:00

  • Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year.

    abstract:BACKGROUND:Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demeth...


    pub_type: 杂志文章


    authors: Hinz D,Bauer M,Röder S,Olek S,Huehn J,Sack U,Borte M,Simon JC,Lehmann I,Herberth G,LINA study group.

    更新日期:2012-03-01 00:00:00

  • Immunological mechanisms of sublingual immunotherapy.

    abstract::Administration of allergen-specific immunotherapy by the oral route, sublingual immunotherapy (SLIT), has been shown to be effective, with an improved safety profile compared with subcutaneous administration. However, the precise mechanisms underlying the induction of immune tolerance by SLIT remain unclear. Contact o...


    pub_type: 杂志文章,评审


    authors: Akdis CA,Barlan IB,Bahceciler N,Akdis M

    更新日期:2006-01-01 00:00:00

  • Dynamics in cytokine responses during the development of occupational sensitization to rats.

    abstract:BACKGROUND:Occupational allergy forms an attractive model to study the development of allergic responses, as in some occupations it has a high incidence and develops quickly. In a cohort of starting laboratory animal workers, we previously found 20% sensitization to animal allergens within 2 years. METHODS:We compared...


    pub_type: 杂志文章


    authors: Krop EJ,van de Pol MA,Lutter R,Heederik DJ,Aalberse RC,van der Zee JS

    更新日期:2010-10-01 00:00:00

  • Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps.

    abstract:BACKGROUND:The role of myeloid and plasmacytoid dendritic cells and its consequences for the T(H)2 skew in chronic rhinosinusitis (CRS) with nasal polyps (CRSNP(+)) should be detailed. METHODS:In 18 CRS patients without nasal polyps (CRSNP(-)), 35 CRSNP(+) patients and 22 patients with nasal structural abnormalities w...


    pub_type: 杂志文章


    authors: Kirsche H,Niederführ A,Deutschle T,Fuchs C,Riechelmann H

    更新日期:2010-01-01 00:00:00