Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3+ Treg cells.

abstract：:This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not compl...

journal_title：Allergy

authors： Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Mastocytosis is characterized by the accumulation of mast cells (MCs) associated with activating mutations of KIT. Tumor necrosis factor-related apoptosis-inducing ligand receptors (TRAIL-Rs) are preferentially expressed on neoplastic cells and induce the extrinsic apoptotic pathway. Recent studies reported ...

journal_title：Allergy

authors： Förster A,Grotha SP,Seeger JM,Rabenhorst A,Gehring M,Raap U,Létard S,Dubreuil P,Kashkar H,Walczak H,Roers A,Hartmann K

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Physicians typically rely heavily on self-reported symptoms to make a diagnosis of exercise-induced bronchoconstriction (EIB). However, in elite sport, respiratory symptoms have poor diagnostic value. In 2009, following a change in international sports regulations, all elite athletes suspected of asthma and/...

journal_title：Allergy

authors： Ansley L,Kippelen P,Dickinson J,Hull JH

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:  Human chemokine-like factor 1 (CKLF1) is a functional ligand for human CCR4, which is highly expressed on Th2 lymphocytes and plays an important role in the pathogenesis of asthma. The expression and function of CKLF1 are associated with asthma. The CKLF1 C-terminal peptides C19 and C27 also interact with ...

journal_title：Allergy

authors： Tian L,Li W,Wang J,Zhang Y,Zheng Y,Qi H,Guo X,Zhang Y,Ma D,Shen H,Wang Y

更新日期：2011-02-01 00:00:00

abstract：:Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and nonallergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments...

journal_title：Allergy

authors： Van Gerven L,Steelant B,Hellings PW

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown. OBJECTIVE:The aim of the study was to evaluate the methylation status of whole genom...

journal_title：Allergy

authors： Cheong HS,Park SM,Kim MO,Park JS,Lee JY,Byun JY,Park BL,Shin HD,Park CS

更新日期：2011-05-01 00:00:00

abstract：:Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted pap...

journal_title：Allergy

authors： Ren MQ,Zhou YT,Chen HX,Li TY,Vajandar SK,Osipowicz T,Watt F,Li CW

更新日期：2018-03-01 00:00:00

abstract：:Taxonomy provides the basis for the identity of species, allowing the construction of keys and the reliable, reproducible identification of dust mites for ecologic purposes and other studies. Details are given of nomenclatorial conventions in taxonomy as applied to dust mites, and taxonomically problematic entities ar...

journal_title：Allergy

authors： Colloff MJ

更新日期：1998-01-01 00:00:00

abstract：:The increase in prevalence and burden of atopic diseases, i.e. eczema, rhinitis, and asthma over the past decades was paralleled by a worldwide increase in attention-deficit/hyperactivity disorder (ADHD) diagnoses. We systematically reviewed epidemiologic studies investigating the relationship between atopic diseases ...

journal_title：Allergy

authors： Schmitt J,Buske-Kirschbaum A,Roessner V

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Eosinophilic airway inflammation is the hallmark of asthma, but it has also been reported in other conditions such as allergic rhinitis. We have tested whether the analysis of cells and chemicals in sputum can distinguish between patients with mild allergic asthma, those with allergic rhinitis, and healthy c...

journal_title：Allergy

authors： Alvarez MJ,Olaguibel JM,García BE,Rodríquez A,Tabar AI,Urbiola E

更新日期：2000-04-01 00:00:00

abstract：:Tiaramide hydrochloride (THC) is a new basic, non-steroidal, anti-flammatory drug. Its anti-anaphylactic action has been investigated using rat mast cells. It was found that THC exerts a strong inhibitory action on antigen-induced and compound 48/80-induced histamine release from rat peritoneal mast cells in a fluorom...

journal_title：Allergy

authors： Renoux ML,Weill BJ,Wallach D,Chwetzoff E

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...

journal_title：Allergy

authors： Simon MR,Mulla ZD

更新日期：2008-08-01 00:00:00

abstract：:Inbred guinea pigs selected for high (IMM/S) respectively low (IMM/R) responsiveness to ovalbumin (OA) as measured by induced respiratory anaphylaxis, were investigated for atopic immune responses of their conjunctival mucosa. IMM/S animals sensitized either by inhalation of OA, or by instillation of antigen into the ...

journal_title：Allergy

authors： Lundberg L,Bertelsen C,Zavaro A,Samra Z,Sompolinsky D

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Date-palm (Phoenix dactylifera L.) fruits are eaten daily by most inhabitants of the Middle East and the neighboring countries. Recent reports have indicated that dates are allergenic. This study aimed to investigate the antigenic and allergenic potential of date fruits. METHODS:Date-fruit extracts from eig...

journal_title：Allergy

authors： Kwaasi AA,Harfi HA,Parhar RS,Al-Sedairy ST,Collison KS,Panzani RC,Al-Mohanna FA

更新日期：1999-12-01 00:00:00

abstract：:Basophils are evolutionarily conserved in many animal species, in spite of the fact that they account for <1% of peripheral blood leukocyte. This suggests that basophils have an indispensable and nonredundant role in vivo, even though they show some phenotypic similarity with tissue-resident mast cells. However, their...

journal_title：Allergy

authors： Karasuyama H,Obata K,Wada T,Tsujimura Y,Mukai K

更新日期：2011-09-01 00:00:00

abstract：:The frequency of aspirin intolerance by history in 2,592 normal individuals was 0.3%. Although the frequency of aspirin intolerance was similar in adults and children, the bronchospastic type predominated in adults, and only the urticarial type was found in normal children. The frequency of recurrent urticaria, regar...

journal_title：Allergy

authors： Settipane RA,Constantine HP,Settipane GA

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pruritic hives. While clinical symptoms are due to the release of histamine by cutaneous mast cells, the underlying pathophysiology is still unknown. However, previous studies indicate that basophils might be of releva...

journal_title：Allergy

authors： Rauber MM,Pickert J,Holiangu L,Möbs C,Pfützner W

更新日期：2017-12-01 00:00:00

abstract：:This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...

journal_title：Allergy

authors： Savolainen J,Kortekangas-Savolainen O,Nermes M,Viander M,Koivikko A,Kalimo K,Terho EO

更新日期：1998-05-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are a recently identified group of cells with the potent capability to produce Th2-type cytokines such as interleukin (IL)-5 and IL-13. Several studies suggest that ILC2s play an important role in the development of allergic diseases and asthma. Activation of pulmonary ILC2s in mu...

journal_title：Allergy

authors： Aron JL,Akbari O

更新日期：2017-08-01 00:00:00

abstract：:Various biological assays are used for qualitative and quantitative measurements of interleukin 1 (IL-1) in supernatants from cell cultures. The purpose of the present study was to compare the specificity and variability of three cellular IL-1 bioassays: the PHA co-stimulatory human T lymphocyte proliferation assay, t...

journal_title：Allergy

authors： Remvig L,Vibe-Petersen J,Svenson M,Enk C,Bendtzen K

更新日期：1991-01-01 00:00:00

abstract：:Several observations have indicated that house-dust mites (HDM) play an important role in allergic diseases. Thus, the primary form of treatment should aim at reducing exposure to HDM for these patients. Allergen-avoidance measures in homes have been demonstrated to be beneficial in decreasing the risk of sensitizatio...

journal_title：Allergy

authors： Kalpaklioğlu AF,Ferizli AG,Misirligil Z,Demirel YS,Gürbüz L

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental asthma. METHODS:ADAM10 was blocked either by using mice with a B-cell-s...

journal_title：Allergy

authors： Mathews JA,Ford J,Norton S,Kang D,Dellinger A,Gibb DR,Ford AQ,Massay H,Kepley CL,Scherle P,Keegan AD,Conrad DH

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Olive tree (Olea europaea) pollen is an important cause of pollinosis in the countries of the Mediterranean area. OBJECTIVE:This work aimed to study the IgE-binding frequency of Ole e 1, Ole e 2, Ole e 3, Ole e 6 and Ole e 7 from O. europaea pollen in a large population of olive pollen-allergic patients. M...

journal_title：Allergy

authors： Quiralte J,Florido F,Arias de Saavedra JM,Gómez A,Sáenz de San Pedro B,González E,Rodríguez R

更新日期：2002-01-01 00:00:00

abstract：:The aim of the study was to develop and evaluate different methods of double-blind, placebo-controlled food challenge (DBPCFC) with apple. Three different DBPCFC models were evaluated: fresh apple juice, freshly grated apple, and freeze-dried apple powder. All challenges were performed outside the pollen season and to...

journal_title：Allergy

authors： Skamstrup Hansen K,Vestergaard H,Stahl Skov P,Søndergaard Khinchi M,Vieths S,Poulsen LK,Bindslev-Jensen C

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE l...

journal_title：Allergy

authors： Tewfik MA,Bossé Y,Lemire M,Hudson TJ,Vallée-Smejda S,Al-Shemari H,Laprise C,Desrosiers M

更新日期：2009-05-01 00:00:00

abstract：:A two-site immunometric assay based on monoclonal antibodies (mAb) was developed for the measurement of a 20-kDa major allergen of cow. The sensitivity of this assay was (BDA20) 1 ng/ml. It was used to measure airborne allergen concentrations in 10 Finnish cowsheds. The mean concentration of the BDA20 measured at two ...

journal_title：Allergy

authors： Ylönen J,Virtanen T,Rytkönen M,Mäntyjärvi R

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Intranasal noninhaled delivery of carbon dioxide (CO₂) is efficacious in the symptomatic treatment of seasonal allergic rhinitis. The goal of this study was to determine whether and how 100% CO₂ inhibits mast cell degranulation, thereby possibly contributing to the reduction of symptoms in seasonal allergic ...

journal_title：Allergy

authors： Strider JW,Masterson CG,Durham PL

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Food allergy may present with a plethora of gastrointestinal and extraintestinal symptoms such as abdominal pain, diarrhea, cardiocirculatory symptoms, cutaneous reactions, or rhinitis. Macropathological lesions like lymphofollicular hyperplasia and erosive or ulcerative lesions have seldom been described in...

journal_title：Allergy

authors： Hagel AF,de Rossi TM,Zopf Y,Lindner AS,Dauth W,Neurath MF,Raithel M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Privet pollen rarely accounts for more than 1% of the annual total of daily pollen concentrations measured in a city; however in areas where these trees are widely used as ornamentals the amounts collected may be high enough to cause allergy symptoms. METHODS:Air samples taken with volumetric particle sampl...

journal_title：Allergy

authors： Cariñanos P,Alcázar P,Galán C,Domínguez E

更新日期：2002-02-01 00:00:00