Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma.

Abstract:

:The standard treatment of allergic rhinitis and asthma consists of topical corticosteroids administered intranasally and inhaled through the mouth. Although this therapy is highly effective, and side-effects are few and mild, it may be possible further to improve the therapeutic index and patient compliance with the treatment. In the present study, we evaluated a nasal inhalation system used for the simultaneous treatment of rhinitis and asthma. In principle, it results in an airway deposition of the corticosteroid similar to that of inhaled allergens. Twenty-four children with perennial rhinitis and asthma inhaled budesonide through the nose from a pressurized aerosol, attached to a spacer device, in a double-blind, placebo-controlled, crossover study. Compared with placebo, budesonide treatment resulted in a significant reduction of nasal symptoms (P<0.01) and of asthma symptoms (P<0.05), and in an increase of nasal peak inspiratory flow (P < 0.001) and of oral peak expiratory flow (P=0.01). There were no differences between budesonide and placebo in local side-effects, such as dry nose, nosebleed, and hoarseness. We conclude that nasal inhalation of a corticosteroid from a spacer offers a simple and effective treatment for both rhinitis and asthma in children, but it is an open question whether the nasal inhalation system can improve the ratio of antirhinitis/antiasthma effects to side-effects.

journal_name

Allergy

journal_title

Allergy

authors

Pedersen W,Hjuler I,Bisgaard H,Mygind N

doi

10.1111/j.1398-9995.1998.tb03909.x

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

383-7

issue

4

eissn

0105-4538

issn

1398-9995

journal_volume

53

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ALLERGY文献大全
  • Oral allergy syndrome (OAS) in pollinosis patients after eating pistachio nuts: two cases with two different patterns of onset.

    abstract::We describe two uncommon cases of oral allergy syndrome (OAS) after eating pistachio nuts (p.n.) in subjects (a 54-year-old man and a 3-year-old girl) with exclusive skin prick test (SPT) positivity to Parietaria (P.) and pistachio nut (p.n.) allergens. Serologic P.- and p.n.-specific IgE determinations were also carr...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1996.tb04493.x

    authors: Liccardi G,Mistrello G,Noschese P,Falagiani P,D'Amato M,D'Amato G

    更新日期:1996-12-01 00:00:00

  • CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis.

    abstract:BACKGROUND:The contribution of B-cell subsets and T-B cell interaction to the pathogenesis of allergic rhinitis (AR) and mechanisms of allergen immunotherapy (AIT) remain poorly understood. This study aimed to outline circulating B-cell signature, the underlying mechanism, and its association with clinical response to ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14288

    authors: Yao Y,Wang N,Chen CL,Pan L,Wang ZC,Yunis J,Chen ZA,Zhang Y,Hu ST,Xu XY,Zhu RF,Yu D,Liu Z

    更新日期:2020-10-01 00:00:00

  • Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites.

    abstract::It is well established that different sites in healthy human skin are colonized by distinct microbial communities due to different physiological conditions. However, few studies have explored microbial heterogeneity between skin sites in diseased skin, such as atopic dermatitis (AD) lesions. To address this issue, we ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14606

    authors: Ottman N,Barrientos-Somarribas M,Fyhrquist N,Alexander H,Wisgrill L,Olah P,Tsoka S,Greco D,Levi-Schaffer F,Soumelis V,Schröder JM,Kere J,Nestle FO,Barker J,Ranki A,Lauerma A,Homey B,Andersson B,Alenius H

    更新日期:2020-10-01 00:00:00

  • Characterization of monocyte subtypes in the allergic form of atopic eczema/dermatitis syndrome.

    abstract:BACKGROUND:Monocyte (Mo) subsets exhibiting distinct phenotypic and functional properties identified in peripheral blood are assumed to be under the control of soluble factors from their surrounding micromilieu. Atopic eczema/dermatitis syndrome (AEDS) is accompanied by humoral and cellular alterations among which an i...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23737.x

    authors: Novak N,Allam P,Geiger E,Bieber T

    更新日期:2002-10-01 00:00:00

  • Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been considered a paradigmatic type 2 immunity (T2)-driven disease. Interleukin (IL)-4 and IL-13 are both pivotal cytokines involved in the generation of allergic diseases. Currently, besides dupilumab, which blocks the binding of bo...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.13954

    authors: Bieber T

    更新日期:2020-01-01 00:00:00

  • Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma.

    abstract:BACKGROUND:Abnormalities, including bronchiectasis, that are detectable on high-resolution computed tomography (HRCT) have been associated with severe asthma. Bronchiectasis is associated with the diagnosis of allergic bronchopulmonary aspergillosis (ABPA), which also occurs in patients with severe asthma. We sought to...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02542.x

    authors: Menzies D,Holmes L,McCumesky G,Prys-Picard C,Niven R

    更新日期:2011-05-01 00:00:00

  • Allergy to date fruits: characterization of antigens and allergens of fruits of the date palm (Phoenix dactylifera L.).

    abstract:BACKGROUND:Date-palm (Phoenix dactylifera L.) fruits are eaten daily by most inhabitants of the Middle East and the neighboring countries. Recent reports have indicated that dates are allergenic. This study aimed to investigate the antigenic and allergenic potential of date fruits. METHODS:Date-fruit extracts from eig...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00116.x

    authors: Kwaasi AA,Harfi HA,Parhar RS,Al-Sedairy ST,Collison KS,Panzani RC,Al-Mohanna FA

    更新日期:1999-12-01 00:00:00

  • Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber.

    abstract:BACKGROUND:Recombinant allergens offer a tool for improving specific immunotherapy (SIT). OBJECTIVE:To find the optimal dose of a new hypoallergenic folding variant of recombinant Bet v 1 (rBet v 1-FV) as SIT for patients with birch pollen allergy. METHODS:Before SIT, thirty-seven adult patients were exposed for eigh...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/all.12148

    authors: Meyer W,Narkus A,Salapatek AM,Häfner D

    更新日期:2013-06-01 00:00:00

  • Histamine release from basophil leukocytes induced by microbial antigen preparations in patients with AIDS.

    abstract::Type I allergy against some common microorganisms was investigated in 14 patients with AIDS and 11 human immunodeficiency virus (HIV) antibody-positive homosexual men, and in a control group consisting of 13 heterosexual men without HIV antibodies. Basophil histamine release technique was used as a sensitive method to...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb02212.x

    authors: Pedersen M,Permin H,Jensen C,Stahl Skov P,Norn S,Faber V

    更新日期:1987-05-01 00:00:00

  • Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults.

    abstract:BACKGROUND:While total IgE measurements are often used in clinical practice, it is unclear how they should be interpreted for the diagnosis of allergic disorders. We studied whether total IgE may be used to rule out or predict sensitization and whether there are age or gender differences. METHODS:ROC curves were asses...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00230.x

    authors: Kerkhof M,Dubois AE,Postma DS,Schouten JP,de Monchy JG

    更新日期:2003-09-01 00:00:00

  • Intensive educational course in allergy and immunology.

    abstract::A one-day intensive educational course on allergy and immunology theory and diagnostic procedure significantly increased the competency of allergy and immunology fellows-in-training. ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2012.02869.x

    authors: Elizalde A,Perez EE,Sriaroon P,Nguyen D,Lockey RF,Dorsey MJ

    更新日期:2012-09-01 00:00:00

  • Clinical and immunologic evaluation of Cedrus deodara pollen: a new allergen from India.

    abstract:BACKGROUND:Allergy to pollen from gymnosperms is well documented in the West. However, many allergenic species are native to the Himalayan region of India, and Cedrus deodara (Pinaceae) was selected for allergologic investigation. The objective was to define the allergologic and immunochemical aspects of C. deodara pol...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2000.00491.x

    authors: Rawat A,Singh A,Singh AB,Gaur SN,Kumar L,Roy I,Ravindrun P

    更新日期:2000-07-01 00:00:00

  • Allergen-induced release of sulphidopeptide leukotrienes (SRS-A) and LTB4 in allergic rhinitis.

    abstract::Leukotrienes are a recently discovered group of arachidonic acid-derived lipid mediators. Using radioimmunoassay and high pressure liquid chromatography (HPLC), we have identified the SRS-A sulphidopeptide leukotrienes (LTC4, LTD4 and LTE4) in nasal washings from patients with allergic rhinitis who underwent nasal cha...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1985.tb04147.x

    authors: Shaw RJ,Fitzharris P,Cromwell O,Wardlaw AJ,Kay AB

    更新日期:1985-01-01 00:00:00

  • Influenza A virus enhances basophil histamine release and the enhancement is abolished by carbohydrates.

    abstract::Basophil histamine release was studied in leukocyte suspensions from normal individuals and from patients allergic to house dust mite or birch pollen. Mediator release caused by IgE-mediated reactions was examined by stimulating the cells with anti-IgE or specific antigens, and the calcium ionophore A23187 was used fo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb01099.x

    authors: Clementsen P,Norn S,Kristensen KS,Hannoun C

    更新日期:1990-08-01 00:00:00

  • Prevalence and features of allergic rhinitis in Italy.

    abstract:BACKGROUND:Italian data on the prevalence of allergic rhinitis are sparse and with wide variations, maybe because of different diagnostic criteria and methods of investigation. This study analyzes the information on rhinitis collected in northern Italy through standardized methods within the European Community Respirat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23537.x

    authors: Olivieri M,Verlato G,Corsico A,Lo Cascio V,Bugiani M,Marinoni A,de Marco R,Italian European Community Respiratory Health Survey group.

    更新日期:2002-07-01 00:00:00

  • Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via the oral route.

    abstract:BACKGROUND:Aluminium (ALUM) is used as experimental and clinical adjuvant for parenteral vaccine formulation. It is also contained in anti-acid drugs like sucralfate (SUC). These anti-acids have been shown to cause sensitization to food proteins via elevation of the gastric pH. The aim of this study was to assess the o...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01933.x

    authors: Brunner R,Wallmann J,Szalai K,Karagiannis P,Altmeppen H,Riemer AB,Jensen-Jarolim E,Pali-Schöll I

    更新日期:2009-06-01 00:00:00

  • Human herpes virus reactivations and dynamic cytokine profiles in patients with cutaneous adverse drug reactions --a prospective comparative study.

    abstract:BACKGROUND:Sequential human herpes virus (HHV) reactivation is well known in drug reaction with eosinophilia and systemic symptom (DRESS), but such a phenomenon has seldom studied in other types of cutaneous adverse drug reactions (cADRs). Moreover, the association between viral reactivations and cytokine or chemokine ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12602

    authors: Chen YC,Chiang HH,Cho YT,Chang CY,Chen KL,Yang CW,Lee YH,Chu CY

    更新日期:2015-05-01 00:00:00

  • Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) in guinea pigs.

    abstract::Effects of a thromboxane synthetase inhibitor (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) were investigated in anesthetized, artificially ventilated guinea pigs in order to examine the role ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1992.tb00961.x

    authors: Saito M,Fujimura M,Sakamoto S,Miyake Y,Shintani H,Yasui M,Matsuda T

    更新日期:1992-04-01 00:00:00

  • Non-specific histamine release activity of busereline, LH-releasing hormone.

    abstract::Busereline acetate is an LH-RH agonist that was found to induce local reactions at the injection site or generalized minor skin reactions in some patients. Since these reactions may represent the first reaction of systemic anaphylaxis, we tested the non-specific histamine releasing activity of this drug by intradermal...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb01634.x

    authors: Bousquet J,Hédon B,Hejjaoui A,Chanal I,Michel FB

    更新日期:1988-10-01 00:00:00

  • Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis.

    abstract:BACKGROUND:Fluticasone furoate is a novel-enhanced affinity glucocorticoid and its long-term safety must be assessed. This study was designed to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR). METHO...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2007.01521.x

    authors: Rosenblut A,Bardin PG,Muller B,Faris MA,Wu WW,Caldwell MF,Fokkens WJ

    更新日期:2007-09-01 00:00:00

  • Anaphylaxis caused by Hymenoptera stings: from epidemiology to treatment.

    abstract::Hymenoptera venom allergy occasionally causes fatal reactions. The prevalence of systemic reactions (SRs) is 0.3-8.9%, with anaphylaxis in 0.3-42.8% of cases. Factors contributing to reaction severity include older age, insect type, a previous less severe SR, preexisting diseases, concomitant treatments, mast cell dis...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02630.x

    authors: Bilò MB

    更新日期:2011-07-01 00:00:00

  • Prenatal allergen exposures prevent allergen-induced sensitization and airway inflammation in young mice.

    abstract:BACKGROUND:Immune-modulation such as tolerance induction appears to be an upcoming concept to prevent development of atopic diseases. Pregnancy might present a critical period for preventing allergic sensitization of the progeny. We investigated the effect of maternal allergen exposures during pregnancy on allergen-ind...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02775.x

    authors: Gerhold K,Avagyan A,Reichert E,Seib C,Van DV,Luger EO,Hutloff A,Hamelmann E

    更新日期:2012-03-01 00:00:00

  • Storage mite allergy among bakers.

    abstract::Allergy to storage mites has been shown among farmers and grain elevator workers. This study aimed to examine whether bakers also are sensitized to storage mites. Twenty-three bakers or other employees in bakeries suffering from nasal or pulmonary symptoms were compared with 17 control persons with no relation to bake...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb00484.x

    authors: Revsbech P,Dueholm M

    更新日期:1990-04-01 00:00:00

  • Taxonomy and identification of dust mites.

    abstract::Taxonomy provides the basis for the identity of species, allowing the construction of keys and the reliable, reproducible identification of dust mites for ecologic purposes and other studies. Details are given of nomenclatorial conventions in taxonomy as applied to dust mites, and taxonomically problematic entities ar...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1998.tb04989.x

    authors: Colloff MJ

    更新日期:1998-01-01 00:00:00

  • Periodic fever syndromes: a diagnostic challenge for the allergist.

    abstract::The objective was to present a case of periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), summarize the medical literature on PFAPA, review the differential diagnosis and suggest a diagnostic approach to periodic fevers in children. A PubMed search was conducted for all case reports an...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2007.01534.x

    authors: Lierl M

    更新日期:2007-12-01 00:00:00

  • Asthma, allergic rhinitis and atopic eczema in Finnish children and adolescents.

    abstract::The parents of 3649 Finnish children and adolescents were interviewed in 1980 to evaluate the prevalence of bronchial asthma, allergic rhinitis and atopic dermatitis. The same group was interviewed 6 years later to determine the incidence of new cases of bronchial asthma in the 1980s. Age- and sex-matched samples were...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1991.tb00564.x

    authors: Pöysä L,Korppi M,Pietikäinen M,Remes K,Juntunen-Backman K

    更新日期:1991-04-01 00:00:00

  • New insights into the sensitization to nonspecific lipid transfer proteins from pollen and food: New role of allergen Ole e 7.

    abstract:BACKGROUND:Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, P...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14086

    authors: Oeo-Santos C,Navas A,Benedé S,Ruíz-León B,Díaz-Perales A,Vogel L,Moreno-Aguilar C,Jurado A,Villalba M,Barderas R

    更新日期:2020-04-01 00:00:00

  • Longitudinal evaluation of bone mass in asthmatic children treated with inhaled beclomethasone dipropionate or cromolyn sodium.

    abstract::Inhaled corticosteroids are recommended as first-line therapy in patients with moderate to severe asthma. The use of these agents in the milder form of asthma is controversial because of their potential adverse effects, especially in growing children. We investigated 49 asthmatic children (38 treated with beclomethaso...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03957.x

    authors: Martinati LC,Bertoldo F,Gasperi E,Fortunati P,Lo Cascio V,Boner AL

    更新日期:1998-07-01 00:00:00

  • Double-blind, placebo-controlled food challenge with apple.

    abstract::The aim of the study was to develop and evaluate different methods of double-blind, placebo-controlled food challenge (DBPCFC) with apple. Three different DBPCFC models were evaluated: fresh apple juice, freshly grated apple, and freeze-dried apple powder. All challenges were performed outside the pollen season and to...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1398-9995.2001.056002109.x

    authors: Skamstrup Hansen K,Vestergaard H,Stahl Skov P,Søndergaard Khinchi M,Vieths S,Poulsen LK,Bindslev-Jensen C

    更新日期:2001-02-01 00:00:00

  • Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study.

    abstract:BACKGROUND:A cross-sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown. METHODS:From the Taiwan National Health Insurance Research Database, 10 455 patients who were diagnosed with ast...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12758

    authors: Cheng CM,Wu YH,Tsai SJ,Bai YM,Hsu JW,Huang KL,Su TP,Li CT,Tsai CF,Yang AC,Lin WC,Pan TL,Chang WH,Chen TJ,Chen MH

    更新日期:2015-12-01 00:00:00