Abstract:
:Antigen-presenting cells (APCs) of the human gut are heterogeneous, including both macrophages, a variety of dendritic cells and B cells. They are found both in gut-associated lymphoid tissue and in the mucosal lamina propria, especially beneath the surface epithelium. APCs have diverse phenotypes and therefore probably different functions in various locations; their expression levels of a variety of costimulatory molecules are most likely important for immunological decision making of stimulated T cells, either locally in the gut or in regional lymph nodes to which migrating APCs (dendritic cells) carry antigen. Thus, APCs are involved in active immunity as well as in induction of oral tolerance. However, their precise role in food allergy remains to be defined.
journal_name
Allergyjournal_title
Allergyauthors
Brandtzaeg Pdoi
10.1034/j.1398-9995.2001.00903.xkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
16-20eissn
0105-4538issn
1398-9995pii
all903journal_volume
56 Suppl 67pub_type
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