Nature and function of gastrointestinal antigen-presenting cells.

Abstract:

:Antigen-presenting cells (APCs) of the human gut are heterogeneous, including both macrophages, a variety of dendritic cells and B cells. They are found both in gut-associated lymphoid tissue and in the mucosal lamina propria, especially beneath the surface epithelium. APCs have diverse phenotypes and therefore probably different functions in various locations; their expression levels of a variety of costimulatory molecules are most likely important for immunological decision making of stimulated T cells, either locally in the gut or in regional lymph nodes to which migrating APCs (dendritic cells) carry antigen. Thus, APCs are involved in active immunity as well as in induction of oral tolerance. However, their precise role in food allergy remains to be defined.

journal_name

Allergy

journal_title

Allergy

authors

Brandtzaeg P

doi

10.1034/j.1398-9995.2001.00903.x

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

16-20

eissn

0105-4538

issn

1398-9995

pii

all903

journal_volume

56 Suppl 67

pub_type

杂志文章,评审

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