The increased number of epithelial mast cells in nasal polyps and adjacent turbinates is not allergy-dependent.

Abstract:

:Respiratory epithelial mast cells are an expression of airway inflammatory processes. Nasal epithelial mast cells are known to be increased in allergic rhinitis and have now been examined in patients with nasal polyps. Metachromatic cell counts (mean +/- standard error) expressed as the sum of large mast cells, atypical mast cells and basophils in epithelial scrapings of the inferior turbinates, assessed after Carnoy's fixation and toluidine blue staining (pH 0.5), were 37.5 +/- 29 in non-allergic normal control subjects (n = 11), 435 +/- 130 in polyp patients who were allergic (n = 18), and 699 +/- 267 in polyp patients who were not allergic (n = 8). Metachromatic cell counts in epithelial scrapings obtained in vivo from nasal polyps of allergic patients (n = 8) were 1769 +/- 962, and 2308 +/- 1544 from polyps of non-allergic patients (n = 5); metachromatic counts were 2089 +/- 633 in epithelial scrapings from excised polyps of allergic patients (n = 14) and 2214 +/- 640 from polyps of non-allergic patients (n = 13). It is concluded that the number of metachromatic cells in the epithelium of nasal polyps and the adjacent nasal mucosa is elevated compared with normal nasal epithelium and the increased number does not depend upon allergy.

journal_name

Allergy

journal_title

Allergy

authors

Ruhno J,Howie K,Anderson M,Andersson B,Vanzieleghem M,Hitch D,Lapp P,Denburg J,Dolovich J

doi

10.1111/j.1398-9995.1990.tb00513.x

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

370-4

issue

5

eissn

0105-4538

issn

1398-9995

journal_volume

45

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Hypersensitivity to cefuroxime with good tolerance to other betalactams.

    abstract::A 60-year-old man developed an anaphylactic reaction immediately after administration of intramuscular sodium cefuroxime. By means of oral controlled challenge, the reaction was reproduced with a smaller dose of cefuroxime axetil. Cross-reactivity with other betalactam antibiotics was ruled out by in vivo tests. This ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb01160.x

    authors: Marcos Bravo C,Luna Ortiz I,González Vázquez R

    更新日期:1995-04-01 00:00:00

  • Quantitative immunoelectrophoretic analysis of extract from cow hair and dander. Characterization of the antigens and identification of the allergens.

    abstract::Quantiative immunoelectrophoresis used for the analysis of a dialysed, centrifuged and freeze-dried extract from cow hair and dander revealed 17 antigens. Five of these were identified as serum proteins. Partial identity to antigens of serum and extract from hair and dander of goat, sheep, swine, horse, dog, cat and g...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1978.tb01544.x

    authors: Prahl P,Weeke B,Løwenstein H

    更新日期:1978-10-01 00:00:00

  • Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine.

    abstract::Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical impro...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1981.tb01852.x

    authors: Permin H,Skov PS,Norn S,Geisler A,Klysner R,Andersen V,Wiik A,Manthorpe R,Nielsen H,Petersen J

    更新日期:1981-08-01 00:00:00

  • Antigen-induced bronchial anaphylaxis in actively sensitized SD rats. Effects of local treatment with anti-asthmatic drugs.

    abstract::We studied the effects of anti-asthmatic and anti-inflammatory drugs on antigen-induced bronchial anaphylactic reactions (BAR) in Sprague Dawley (SD) rats immunized with ovalbumin (OA) and alum. The animals were treated locally (intratracheal instillation (i.t.) or by aerosol) with terbutaline (TERB), disodium cromogl...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00352.x

    authors: Dahlbäck M,Brattsand R

    更新日期:1986-11-01 00:00:00

  • Prevalence of lysozyme sensitization in an egg-allergic population.

    abstract::An egg protein, lysozyme, is a still unlabeled additive currently used in cheese preparation. Furthermore, the WHO-FAO committee considers it innocuous. However, 31% of children and 8% of adults with food allergies are allergic to eggs. This work aimed to determine the percentage of patients sensitized to lysozyme fro...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb00980.x

    authors: Frémont S,Kanny G,Nicolas JP,Moneret-Vautrin DA

    更新日期:1997-02-01 00:00:00

  • Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use.

    abstract:BACKGROUND:Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood. AIMS OF THE STUDY:To compare sociodemographic, clinical...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13326

    authors: Schmitt J,Buske-Kirschbaum A,Tesch F,Trikojat K,Stephan V,Abraham S,Bauer A,Nemat K,Plessow F,Roessner V

    更新日期:2018-03-01 00:00:00

  • Artificial neural network identifies nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (N-ERD) cohort.

    abstract:BACKGROUND:To date, there has been no reliable in vitro test to either diagnose or differentiate nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). The aim of the present study was to develop and validate an artificial neural network (ANN) for the prediction of N-ERD in patients with a...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14214

    authors: Tyrak KE,Pajdzik K,Konduracka E,Ćmiel A,Jakieła B,Celejewska-Wójcik N,Trąd G,Kot A,Urbańska A,Zabiegło E,Kacorzyk R,Kupryś-Lipińska I,Oleś K,Kuna P,Sanak M,Mastalerz L

    更新日期:2020-07-01 00:00:00

  • CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle.

    abstract:BACKGROUND:CD40 and OX40 Ligand (OX40L) are cell-surface molecules expressed on airway smooth muscle (ASM) that can enhance inflammatory cell activation and survival. The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expres...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.01959.x

    authors: Krimmer DI,Loseli M,Hughes JM,Oliver BG,Moir LM,Hunt NH,Black JL,Burgess JK

    更新日期:2009-07-01 00:00:00

  • Safety and reproducibility of nasal allergen challenge.

    abstract:BACKGROUND:The nasal allergen challenge (NAC) is a useful tool for the diagnosis of allergic rhinitis (AR) and local allergic rhinitis (LAR) and might serve to design and monitor allergen immunotherapy. Nevertheless, data about its safety and reproducibility are scarce. OBJECTIVE:To investigate the safety and reproduc...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13728

    authors: Eguiluz-Gracia I,Testera-Montes A,González M,Pérez-Sánchez N,Ariza A,Salas M,Moreno-Aguilar C,Campo P,Torres MJ,Rondon C

    更新日期:2019-06-01 00:00:00

  • Risks of allergic reactions to biotech proteins in foods: perception and reality.

    abstract::In recent years, significant attention has been paid to the use of biotechnology to improve the quality and quantity of the food supply due in part to the projected growth in the world population, plus limited options available for increasing the amount of land under cultivation. Alterations in the food supply induced...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2005.00704.x

    authors: Lehrer SB,Bannon GA

    更新日期:2005-05-01 00:00:00

  • Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.

    abstract::Six children and six adults were given a single dose of a sustained release theophylline preparation (Nuelin Retard) after an overnight fast and later after a standardized breakfast. Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food. ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1982.tb02336.x

    authors: Pedersen S,Moeller-Petersen J

    更新日期:1982-10-01 00:00:00

  • Regulatory functions of B cells in allergic diseases.

    abstract::B cells are essentially described for their capacity to produce antibodies ensuring anti-infectious immunity or deleterious responses in the case of autoimmunity or allergy. However, abundant data described their ability to restrain inflammation by diverse mechanisms. In allergy, some regulatory B-cell subsets produci...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12490

    authors: Braza F,Chesne J,Castagnet S,Magnan A,Brouard S

    更新日期:2014-11-01 00:00:00

  • Dose response relationship of allergen, histamine, and histamine releasers in skin prick test and precision of the skin prick test method.

    abstract::The aim of the present investigation was to study the dose response relationship of allergen, histamine and histamine releasers in skin prick test (SPT) and the precision of the SPT method. In one experiment timothy allergen, histamine HCl, rabbit anti-human-IgE and compound 48/80 were studied in seven patients. In a ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb02369.x

    authors: Dreborg S,Holgersson M,Nilsson G,Zetterström O

    更新日期:1987-02-01 00:00:00

  • The effect of fluticasone propionate aqueous nasal spray on nasal mucosal inflammation in perennial allergic rhinitis.

    abstract::Mast cell degranulation, and the subsequent recruitment of infiltrating inflammatory cells, such as eosinophils, into the nasal mucosa has long been considered the most important model to explain allergic rhinitis. Several studies show a decrease in the number of eosinophils and possibly also mast cells during local c...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1995.tb02737.x

    authors: Godthelp T,Holm AF,Blom H,Klein-Jan A,Rijntjes E,Fokkens WJ

    更新日期:1995-01-01 00:00:00

  • The burden of atopy and asthma in children.

    abstract:BACKGROUND:There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS:MEDLINE was searched for articles re...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2004.00563.x

    authors: O'Connell EJ

    更新日期:2004-08-01 00:00:00

  • Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance.

    abstract:BACKGROUND:Bronchial asthma is a chronic disease characterized by inflammation, obstruction, and hyperresponsiveness of the airways. There is currently no curative therapy for asthma. Type 2 helper T cell response plays a critical role in the pathogenesis of the disease. Protein S is a glycoprotein endowed with anticoa...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14261

    authors: Asayama K,Kobayashi T,D'Alessandro-Gabazza CN,Toda M,Yasuma T,Fujimoto H,Okano T,Saiki H,Takeshita A,Fujiwara K,Fridman D'Alessandro V,Nishihama K,Totoki T,Inoue R,Takei Y,Gabazza EC

    更新日期:2020-09-01 00:00:00

  • Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers.

    abstract:BACKGROUND:Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. OBJECTIVE:To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite athletes and co...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12540

    authors: Seys SF,Hox V,Van Gerven L,Dilissen E,Marijsse G,Peeters E,Dekimpe E,Kasran A,Aertgeerts S,Troosters T,Vanbelle V,Peers K,Ceuppens JL,Hellings PW,Dupont LJ,Bullens DM

    更新日期:2015-02-01 00:00:00

  • Clinical correlates of rhinovirus infection in preschool asthma.

    abstract:BACKGROUND:Investigation of preschool asthma is important since not all children outgrow their illness during this age. Data are scarce on the role of rhinovirus (RV) infections in this patient group. OBJECTIVES:To investigate the role of RV infections in preschool asthma: (i) susceptibility factors, (ii) clinical cou...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14479

    authors: Jartti T,Liimatainen U,Xepapadaki P,Vahlberg T,Bachert C,Finotto S,Kowalski ML,Sobanska A,Lukkarinen H,Pasioti M,Vuorinen T,Zhang N,Zimmermann T,Papadopoulos NG

    更新日期:2021-01-01 00:00:00

  • Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin.

    abstract::In recent years, patients allergic to amoxicillin (AX) but with good tolerance of penicillin G (PG) have been described. It has been suggested that the epitope implicated in this type of sensitization might be located on the side-chain of the AX molecule. Thus, cross-reactivity between AX and cephadroxil (CEPH), a cep...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:

    authors: Sastre J,Quijano LD,Novalbos A,Hernandez G,Cuesta J,de las Heras M,Lluch M,Fernandez M

    更新日期:1996-06-01 00:00:00

  • Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas.

    abstract:BACKGROUND:Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2012.02846.x

    authors: Ghiani A,Aina R,Asero R,Bellotto E,Citterio S

    更新日期:2012-07-01 00:00:00

  • Egg white proteins as inhalant allergens associated with baker's asthma.

    abstract:BACKGROUND:Bakery workers may develop IgE-mediated allergy to liquid and aerosolized hen's egg proteins that are commonly used in the baking and confectionery industries. METHODS:We studied four bakery workers who had work-related allergic respiratory symptoms upon exposure to egg aerosols. The causative role of egg p...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00201.x

    authors: Escudero C,Quirce S,Fernández-Nieto M,Miguel J,Cuesta J,Sastre J

    更新日期:2003-07-01 00:00:00

  • Primary care: the cornerstone of diagnosis of allergic rhinitis.

    abstract::Allergic rhinitis (AR) is a very common disease with over 600 million people (200 million of them with concomitant asthma) worldwide suffering from it. The majority of patients who seek medical advice are seen in primary care. Although there is a selection of guidelines focused on the management of AR, there is a pauc...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2008.01653.x

    authors: Ryan D,van Weel C,Bousquet J,Toskala E,Ahlstedt S,Palkonen S,van den Nieuwenhof L,Zuberbier T,Wickman M,Fokkens W

    更新日期:2008-08-01 00:00:00

  • n-Nonanoyl-CCL14 (NNY-CCL14), a novel inhibitor of allergic airway inflammation is a partial agonist of human CCR2.

    abstract:BACKGROUND:Modulation of leukocyte recruitment through blocking of chemokine receptors has been proposed as an attractive therapeutic strategy. We have previously demonstrated that n-Nonanoyl-CC chemokine ligand 14 (NNY-CCL14), a modified analog of the naturally occurring chemokine CCL14(9-74) internalizes and desensit...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01787.x

    authors: Gupta S,Erdmann G,Schulz-Maronde S,Escher SE,Richter R,Forssmann WG,Elsner J,Forssmann U

    更新日期:2008-10-01 00:00:00

  • CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis.

    abstract:BACKGROUND:The contribution of B-cell subsets and T-B cell interaction to the pathogenesis of allergic rhinitis (AR) and mechanisms of allergen immunotherapy (AIT) remain poorly understood. This study aimed to outline circulating B-cell signature, the underlying mechanism, and its association with clinical response to ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14288

    authors: Yao Y,Wang N,Chen CL,Pan L,Wang ZC,Yunis J,Chen ZA,Zhang Y,Hu ST,Xu XY,Zhu RF,Yu D,Liu Z

    更新日期:2020-10-01 00:00:00

  • Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.

    abstract::Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the develo...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.14582

    authors: Breiteneder H,Peng YQ,Agache I,Diamant Z,Eiwegger T,Fokkens WJ,Traidl-Hoffmann C,Nadeau K,O'Hehir RE,O'Mahony L,Pfaar O,Torres MJ,Wang DY,Zhang L,Akdis CA

    更新日期:2020-09-07 00:00:00

  • Green, Yellow, and Red risk perception in everyday life - a communication tool.

    abstract:BACKGROUND:Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families, and their friends. METHODS:The web-based 'Colours Of Risks' (COR) questionnaire...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13095

    authors: Stensgaard A,DunnGalvin A,Nielsen D,Munch M,Bindslev-Jensen C

    更新日期:2017-07-01 00:00:00

  • Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis.

    abstract::Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1398-9995.1998.tb03890.x

    authors: Moll B,Klimek L,Eggers G,Mann W

    更新日期:1998-03-01 00:00:00

  • The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy.

    abstract:BACKGROUND:As in vitro diagnosis of wasp venom sensitization by specific serum IgE has a sensitivity of only 60-80%, additional in vitro tests are desirable. Basophil activation is associated with the expression of CD63 and its measurement has been proposed as a novel in vitro test for immediate-type allergy. Furthermo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00624.x

    authors: Erdmann SM,Sachs B,Kwiecien R,Moll-Slodowy S,Sauer I,Merk HF

    更新日期:2004-10-01 00:00:00

  • Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics.

    abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01342.x

    authors: Kay AB,Ali FR,Heaney LG,Benyahia F,Soh CP,Renz H,Lee TH,Larché M

    更新日期:2007-05-01 00:00:00

  • The exposome in atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, ...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.13946

    authors: Stefanovic N,Flohr C,Irvine AD

    更新日期:2020-01-01 00:00:00