Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses.

Abstract:

BACKGROUND:Recent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu. OBJECTIVE:To evaluate whether inhalation of S. aureus-derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseases. METHODS:Staphylococcus aureus EV were prepared by sequential ultrafiltration and ultracentrifugation. The innate immune response was evaluated in vitro after the application of EV to airway epithelial cells and alveolar macrophages. In vivo innate and adaptive immune responses were evaluated after airway exposure to EV. Adjuvant effects of EV on the development of hypersensitivity to inhaled allergens were also evaluated after airway sensitization with S. aureus EV and ovalbumin (OVA). RESULTS:Staphylococcus aureus and S. aureus EV were detected in house dust. Alveolar macrophages produced both tumor necrosis α (TNF-α) and interleukin 6 (IL-6) after in vitro stimulation with S. aureus EV, whereas airway epithelial cells produced only IL-6. Repeated airway exposure to S. aureus EV induced both Th1 and Th17 cell responses and neutrophilic pulmonary inflammation, mainly via a Toll-like receptor 2 (TLR2)-dependent mechanism. In terms of adjuvant effects, airway sensitization with S. aureus EV and OVA resulted in neutrophilic pulmonary inflammation after OVA challenge alone. This phenotype was partly reversed by the absence of interferon γ (IFN-γ) or IL-17. CONCLUSION:Staphylococcus aureus EV can induce Th1 and Th17 neutrophilic pulmonary inflammation, mainly in a TLR2-dependent manner. Additionally, S. aureus EV enhance the development of airway hypersensitivity to inhaled allergens.

journal_name

Allergy

journal_title

Allergy

authors

Kim MR,Hong SW,Choi EB,Lee WH,Kim YS,Jeon SG,Jang MH,Gho YS,Kim YK

doi

10.1111/all.12001

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1271-81

issue

10

eissn

0105-4538

issn

1398-9995

journal_volume

67

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin.

    abstract::In recent years, patients allergic to amoxicillin (AX) but with good tolerance of penicillin G (PG) have been described. It has been suggested that the epitope implicated in this type of sensitization might be located on the side-chain of the AX molecule. Thus, cross-reactivity between AX and cephadroxil (CEPH), a cep...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:

    authors: Sastre J,Quijano LD,Novalbos A,Hernandez G,Cuesta J,de las Heras M,Lluch M,Fernandez M

    更新日期:1996-06-01 00:00:00

  • Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients.

    abstract::We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1988.tb00409.x

    authors: Cavaillon JM,Fitting C,Guinnepain MT,Rassemont R,David B

    更新日期:1988-02-01 00:00:00

  • Bee moth (Galleria mellonella) allergic reactions are caused by several thermolabile antigens.

    abstract:BACKGROUND:Exposure and contact with bee moth (Galleria mellonella) larvae (Gm) can cause an allergic reaction both in anglers and breeders. We described the case of an amateur fisherman who experienced an allergic reaction using Gm but not using heat-treated Gm (h-Gm) (mummies). The aim of this study was to demonstrat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00446.x

    authors: Villalta D,Martelli P,Mistrello G,Roncarolo D,Zanoni D

    更新日期:2004-09-01 00:00:00

  • Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN.

    abstract::This update aimed to review the new evidence available to support or refute prior Allergic Rhinitis and its Impact on Asthma (ARIA) statements. A Medline search of publications between 2000 and 2005 was conducted, with articles selected by experts. New evidence supports previous ARIA statements, such as: (i) allergic ...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2007.01551.x

    authors: Cruz AA,Popov T,Pawankar R,Annesi-Maesano I,Fokkens W,Kemp J,Ohta K,Price D,Bousquet J,ARIA Initiative Scientific Committee.

    更新日期:2007-01-01 00:00:00

  • Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases.

    abstract:BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2007.01473.x

    authors: Fraj J,Valero A,Vives R,Pérez I,Borja J,Izquierdo I,Picado C

    更新日期:2008-01-01 00:00:00

  • New insights into the sensitization to nonspecific lipid transfer proteins from pollen and food: New role of allergen Ole e 7.

    abstract:BACKGROUND:Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, P...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14086

    authors: Oeo-Santos C,Navas A,Benedé S,Ruíz-León B,Díaz-Perales A,Vogel L,Moreno-Aguilar C,Jurado A,Villalba M,Barderas R

    更新日期:2020-04-01 00:00:00

  • Food-induced cutaneous adverse reactions.

    abstract::The skin is the most frequently affected target organ in allergy or intolerance of food and food additives. The most common manifestation is acute urticaria (with or without angioedema), accounting for 40-60% of patients with IgE-mediated food allergy, whereas food additives rather aggravate chronic urticaria (intoler...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1998.tb04983.x

    authors: Wüthrich B

    更新日期:1998-01-01 00:00:00

  • Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma.

    abstract:BACKGROUND:Although asthma is characterized by variable airways obstruction, most studies of asthma phenotypes are cross-sectional. The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan-European BIOAIR cohort of adult asthmatics. ...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/all.12445

    authors: Kupczyk M,Dahlén B,Sterk PJ,Nizankowska-Mogilnicka E,Papi A,Bel EH,Chanez P,Howarth PH,Holgate ST,Brusselle G,Siafakas NM,Gjomarkaj M,Dahlén SE,BIOAIR investigators.

    更新日期:2014-09-01 00:00:00

  • Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year.

    abstract:BACKGROUND:Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demeth...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02767.x

    authors: Hinz D,Bauer M,Röder S,Olek S,Huehn J,Sack U,Borte M,Simon JC,Lehmann I,Herberth G,LINA study group.

    更新日期:2012-03-01 00:00:00

  • Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients.

    abstract:BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01383.x

    authors: Sullivan SD,Wenzel SE,Bresnahan BW,Zheng B,Lee JH,Pritchard M,Kamath TV,Weiss ST,TENOR Study Group.

    更新日期:2007-06-01 00:00:00

  • Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Immunotherapy with Hymenoptera venoms is highly effective but causes allergic side-effects frequently, especially when honeybee venom is used. Therefore, our objective was to investigate the effect of pretreatment with the antihistamine fexofenadine on the incidence of allergic side-effects during ultrarush ...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1398-9995.2000.00520.x

    authors: Reimers A,Hari Y,Müller U

    更新日期:2000-05-01 00:00:00

  • Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics.

    abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2007.01342.x

    authors: Kay AB,Ali FR,Heaney LG,Benyahia F,Soh CP,Renz H,Lee TH,Larché M

    更新日期:2007-05-01 00:00:00

  • Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3+ Treg cells.

    abstract:BACKGROUND:Chitotriosidase (chitinase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. However, the role and the mechanisms that underlie these contributions to the diseases have not been...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13426

    authors: Hong JY,Kim M,Sol IS,Kim KW,Lee CM,Elias JA,Sohn MH,Lee CG

    更新日期:2018-08-01 00:00:00

  • Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms.

    abstract:BACKGROUND:Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined. PATIENTS AND METHODS:We evaluated the diagnost...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1398-9995.2007.01351.x

    authors: Canani RB,Ruotolo S,Auricchio L,Caldore M,Porcaro F,Manguso F,Terrin G,Troncone R

    更新日期:2007-07-01 00:00:00

  • An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge.

    abstract::Quantitative determinations of the inflammatory mediators in nasal secretions were performed and correlated with the objective nasal symptoms within 1 h after nasal allergen challenge (NAC). Twenty-six patients with seasonal allergic rhinitis were enrolled outside the pollen season. All measurements were performed bef...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1997.tb00970.x

    authors: Wang D,Smitz J,Waterschoot S,Clement P

    更新日期:1997-02-01 00:00:00

  • A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis.

    abstract:BACKGROUND:With the current increasing incidence of allergies worldwide, new treatments showing efficacy and long term safety are needed for chronic conditions such as persistent allergic rhinitis (PER). New generation H1-antihistamines have demonstrated anti-allergic properties, which could possibly enhance their effe...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2008.01668.x

    authors: Fantin S,Maspero J,Bisbal C,Agache I,Donado E,Borja J,Mola O,Izquierdo I,international Rupatadine study group.

    更新日期:2008-07-01 00:00:00

  • Pulmonary function changes in asthmatics associated with low-level SO2 and NO2 air pollution, weather, and medicine intake. An 8-month prospective study analyzed by neural networks.

    abstract::This paper presents the response in subjects with asthma to gaseous air-pollution levels, weather, and medicine intake as identified by principal-component analysis and neural network techniques. Pulmonary function measured by respiratory peak-flow rate in nonallergic asthmatics was associated with ambient, low-level,...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1993.tb02402.x

    authors: Moseholm L,Taudorf E,Frøsig A

    更新日期:1993-07-01 00:00:00

  • Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells.

    abstract:BACKGROUND:Alkaline serine proteases from six prevalent airborne Penicillium and Aspergillus species have been identified as a group of major allergens (group 13). After entering human airways, the allergens are in initial contacts with respiratory epithelial cells. The purpose of this study is to investigate interacti...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00958.x

    authors: Tai HY,Tam MF,Chou H,Peng HJ,Su SN,Perng DW,Shen HD

    更新日期:2006-03-01 00:00:00

  • A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis.

    abstract:BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02444.x

    authors: Wang H,Chavali S,Mobini R,Muraro A,Barbon F,Boldrin D,Aberg N,Benson M

    更新日期:2011-01-01 00:00:00

  • Comparative evaluation between two immunoenzymatic techniques (FAST and Phadezym) and the Phadebas RAST in food allergy.

    abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb00466.x

    authors: Moneret-Vautrin DA,Gueant JL,Abdel-Ghani A,Maria Y,Nicolas JP

    更新日期:1990-02-01 00:00:00

  • Birch pollen allergy in Europe.

    abstract::Birch and other related trees of the families Betulaceae and Fagaceae (alder, hazel, oak, hornbeam, chestnut, and beech) constitute the birch homologous group. This grouping is primarily based on the extensive IgE cross-reactivity of allergen homologs to the major birch allergen Bet v 1. Birch pollen is the most domin...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.13758

    authors: Biedermann T,Winther L,Till SJ,Panzner P,Knulst A,Valovirta E

    更新日期:2019-07-01 00:00:00

  • Complete mattress encasing is not superior to partial encasing in the reduction of mite allergen.

    abstract:BACKGROUND:Partial mattress encasing was found to be effective in reducing exposure to mite allergen in our previous investigation. We aimed to compare the short-term efficacy of partial and complete mattress encasing and to study mite-allergen levels within these mattresses. METHODS:Thirty-one mattresses with high mi...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.1999.00060.x

    authors: Vichyanond P,Uthaisangsook S,Ruangruk S,Malainual N

    更新日期:1999-07-01 00:00:00

  • TRPV1-mediated itch in seasonal allergic rhinitis.

    abstract:BACKGROUND:Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). AIM OF THE STUDY:To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.01937.x

    authors: Alenmyr L,Högestätt ED,Zygmunt PM,Greiff L

    更新日期:2009-05-01 00:00:00

  • Anaphylactic reaction caused by neoallergens in heated pecan nut.

    abstract::An atopic girl experienced an anaphylactic reaction after eating cookies containing pecan nuts. Investigations revealed that she had developed IgE antibodies exclusively specific against allergenic determinants present in aged or heated pecan nuts, but not in fresh pecans. These neoallergenic determinants were located...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb02513.x

    authors: Malanin K,Lundberg M,Johansson SG

    更新日期:1995-12-01 00:00:00

  • Allergy to jackfruit: a novel example of Bet v 1-related food allergy.

    abstract:BACKGROUND:Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens. OBJECTIVE:Establish whether jackfruit allergy is linked to birchpollen allergy. METHODS:Two jackfruit allergic patients and five patients with...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00544.x

    authors: Bolhaar ST,Ree R,Bruijnzeel-Koomen CA,Knulst AC,Zuidmeer L

    更新日期:2004-11-01 00:00:00

  • Influence of hyposensitization on soluble interleukin-2 receptor, eosinophil cationic protein, in vitro lymphocyte proliferation, in vitro lymphocyte adhesion, and lymphocyte membrane markers in childhood asthma.

    abstract::Soluble interleukin-2 receptor (sIL-2R), eosinophil cationic protein (ECP), the lymphoproliferative response to house-dust mite (HDM), adhesion to human umbilical vein endothelial cells (HUVEC), and lymphocyte membrane markers were studied in three groups of children: healthy children, asthmatic children without hypos...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00135.x

    authors: Moens MM,Van Bever HP,Stevens WJ,Mertens AV,Bridts CH,De Clerck LS

    更新日期:1994-09-01 00:00:00

  • Detection of specific IgE antibodies towards cat flea (Ctenocephalides felis felis) in patients with suspected cat allergy.

    abstract::Cat flea sensitivity is considered one of the most important skin diseases in cats and dogs. Cat fleas, however, are also a growing allergen problem for humans. Cat flea-specific IgE antibodies were studied in serum samples from 70 patients with suspected cat allergy, using RAST-based techniques and the nitrocellulose...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb02196.x

    authors: Rolfsen W,Schröder H,Tibell C,Tibell M

    更新日期:1987-04-01 00:00:00

  • Heat-labile Escherichia coli toxin enhances the induction of allergen-specific IgG antibodies in epicutaneous patch vaccination.

    abstract::Epicutaneous allergen-specific immunotherapy (EPIT) is proposed as an alternative route for allergen-specific immunotherapy (AIT). The induction of allergen-specific blocking IgG antibodies represents an important mechanism underlying AIT, but has not been investigated for EPIT. Here, we compared the induction of alle...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13036

    authors: Cabauatan CR,Campana R,Niespodziana K,Reinisch C,Lundberg U,Meinke A,Henning R,Neubauer A,Valenta R

    更新日期:2017-01-01 00:00:00

  • Biological assays for interleukin 1 detection. Comparison of human T lymphocyte, murine thymocyte and NOB-1 assays.

    abstract::Various biological assays are used for qualitative and quantitative measurements of interleukin 1 (IL-1) in supernatants from cell cultures. The purpose of the present study was to compare the specificity and variability of three cellular IL-1 bioassays: the PHA co-stimulatory human T lymphocyte proliferation assay, t...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1991.tb00544.x

    authors: Remvig L,Vibe-Petersen J,Svenson M,Enk C,Bendtzen K

    更新日期:1991-01-01 00:00:00

  • Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients.

    abstract:BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00841.x

    authors: Platzer MH,Grattan CE,Poulsen LK,Skov PS

    更新日期:2005-09-01 00:00:00