Abstract:
BACKGROUND:Recent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu. OBJECTIVE:To evaluate whether inhalation of S. aureus-derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseases. METHODS:Staphylococcus aureus EV were prepared by sequential ultrafiltration and ultracentrifugation. The innate immune response was evaluated in vitro after the application of EV to airway epithelial cells and alveolar macrophages. In vivo innate and adaptive immune responses were evaluated after airway exposure to EV. Adjuvant effects of EV on the development of hypersensitivity to inhaled allergens were also evaluated after airway sensitization with S. aureus EV and ovalbumin (OVA). RESULTS:Staphylococcus aureus and S. aureus EV were detected in house dust. Alveolar macrophages produced both tumor necrosis α (TNF-α) and interleukin 6 (IL-6) after in vitro stimulation with S. aureus EV, whereas airway epithelial cells produced only IL-6. Repeated airway exposure to S. aureus EV induced both Th1 and Th17 cell responses and neutrophilic pulmonary inflammation, mainly via a Toll-like receptor 2 (TLR2)-dependent mechanism. In terms of adjuvant effects, airway sensitization with S. aureus EV and OVA resulted in neutrophilic pulmonary inflammation after OVA challenge alone. This phenotype was partly reversed by the absence of interferon γ (IFN-γ) or IL-17. CONCLUSION:Staphylococcus aureus EV can induce Th1 and Th17 neutrophilic pulmonary inflammation, mainly in a TLR2-dependent manner. Additionally, S. aureus EV enhance the development of airway hypersensitivity to inhaled allergens.
journal_name
Allergyjournal_title
Allergyauthors
Kim MR,Hong SW,Choi EB,Lee WH,Kim YS,Jeon SG,Jang MH,Gho YS,Kim YKdoi
10.1111/all.12001subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1271-81issue
10eissn
0105-4538issn
1398-9995journal_volume
67pub_type
杂志文章相关文献
ALLERGY文献大全abstract::In recent years, patients allergic to amoxicillin (AX) but with good tolerance of penicillin G (PG) have been described. It has been suggested that the epitope implicated in this type of sensitization might be located on the side-chain of the AX molecule. Thus, cross-reactivity between AX and cephadroxil (CEPH), a cep...
journal_title:Allergy
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb00409.x
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Exposure and contact with bee moth (Galleria mellonella) larvae (Gm) can cause an allergic reaction both in anglers and breeders. We described the case of an amateur fisherman who experienced an allergic reaction using Gm but not using heat-treated Gm (h-Gm) (mummies). The aim of this study was to demonstrat...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00446.x
更新日期:2004-09-01 00:00:00
abstract::This update aimed to review the new evidence available to support or refute prior Allergic Rhinitis and its Impact on Asthma (ARIA) statements. A Medline search of publications between 2000 and 2005 was conducted, with articles selected by experts. New evidence supports previous ARIA statements, such as: (i) allergic ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01551.x
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1398-9995.2007.01473.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, P...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14086
更新日期:2020-04-01 00:00:00
abstract::The skin is the most frequently affected target organ in allergy or intolerance of food and food additives. The most common manifestation is acute urticaria (with or without angioedema), accounting for 40-60% of patients with IgE-mediated food allergy, whereas food additives rather aggravate chronic urticaria (intoler...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1998.tb04983.x
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Although asthma is characterized by variable airways obstruction, most studies of asthma phenotypes are cross-sectional. The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan-European BIOAIR cohort of adult asthmatics. ...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.12445
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demeth...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02767.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01383.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Immunotherapy with Hymenoptera venoms is highly effective but causes allergic side-effects frequently, especially when honeybee venom is used. Therefore, our objective was to investigate the effect of pretreatment with the antihistamine fexofenadine on the incidence of allergic side-effects during ultrarush ...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.2000.00520.x
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01342.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Chitotriosidase (chitinase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. However, the role and the mechanisms that underlie these contributions to the diseases have not been...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13426
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined. PATIENTS AND METHODS:We evaluated the diagnost...
journal_title:Allergy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1398-9995.2007.01351.x
更新日期:2007-07-01 00:00:00
abstract::Quantitative determinations of the inflammatory mediators in nasal secretions were performed and correlated with the objective nasal symptoms within 1 h after nasal allergen challenge (NAC). Twenty-six patients with seasonal allergic rhinitis were enrolled outside the pollen season. All measurements were performed bef...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb00970.x
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:With the current increasing incidence of allergies worldwide, new treatments showing efficacy and long term safety are needed for chronic conditions such as persistent allergic rhinitis (PER). New generation H1-antihistamines have demonstrated anti-allergic properties, which could possibly enhance their effe...
journal_title:Allergy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1398-9995.2008.01668.x
更新日期:2008-07-01 00:00:00
abstract::This paper presents the response in subjects with asthma to gaseous air-pollution levels, weather, and medicine intake as identified by principal-component analysis and neural network techniques. Pulmonary function measured by respiratory peak-flow rate in nonallergic asthmatics was associated with ambient, low-level,...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1993.tb02402.x
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Alkaline serine proteases from six prevalent airborne Penicillium and Aspergillus species have been identified as a group of major allergens (group 13). After entering human airways, the allergens are in initial contacts with respiratory epithelial cells. The purpose of this study is to investigate interacti...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00958.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02444.x
更新日期:2011-01-01 00:00:00
abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1990.tb00466.x
更新日期:1990-02-01 00:00:00
abstract::Birch and other related trees of the families Betulaceae and Fagaceae (alder, hazel, oak, hornbeam, chestnut, and beech) constitute the birch homologous group. This grouping is primarily based on the extensive IgE cross-reactivity of allergen homologs to the major birch allergen Bet v 1. Birch pollen is the most domin...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13758
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Partial mattress encasing was found to be effective in reducing exposure to mite allergen in our previous investigation. We aimed to compare the short-term efficacy of partial and complete mattress encasing and to study mite-allergen levels within these mattresses. METHODS:Thirty-one mattresses with high mi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00060.x
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). AIM OF THE STUDY:To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.01937.x
更新日期:2009-05-01 00:00:00
abstract::An atopic girl experienced an anaphylactic reaction after eating cookies containing pecan nuts. Investigations revealed that she had developed IgE antibodies exclusively specific against allergenic determinants present in aged or heated pecan nuts, but not in fresh pecans. These neoallergenic determinants were located...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb02513.x
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens. OBJECTIVE:Establish whether jackfruit allergy is linked to birchpollen allergy. METHODS:Two jackfruit allergic patients and five patients with...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2004.00544.x
更新日期:2004-11-01 00:00:00
abstract::Soluble interleukin-2 receptor (sIL-2R), eosinophil cationic protein (ECP), the lymphoproliferative response to house-dust mite (HDM), adhesion to human umbilical vein endothelial cells (HUVEC), and lymphocyte membrane markers were studied in three groups of children: healthy children, asthmatic children without hypos...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00135.x
更新日期:1994-09-01 00:00:00
abstract::Cat flea sensitivity is considered one of the most important skin diseases in cats and dogs. Cat fleas, however, are also a growing allergen problem for humans. Cat flea-specific IgE antibodies were studied in serum samples from 70 patients with suspected cat allergy, using RAST-based techniques and the nitrocellulose...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb02196.x
更新日期:1987-04-01 00:00:00
abstract::Epicutaneous allergen-specific immunotherapy (EPIT) is proposed as an alternative route for allergen-specific immunotherapy (AIT). The induction of allergen-specific blocking IgG antibodies represents an important mechanism underlying AIT, but has not been investigated for EPIT. Here, we compared the induction of alle...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13036
更新日期:2017-01-01 00:00:00
abstract::Various biological assays are used for qualitative and quantitative measurements of interleukin 1 (IL-1) in supernatants from cell cultures. The purpose of the present study was to compare the specificity and variability of three cellular IL-1 bioassays: the PHA co-stimulatory human T lymphocyte proliferation assay, t...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1991.tb00544.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00841.x
更新日期:2005-09-01 00:00:00