Genetic variations in toll-like receptor pathway genes influence asthma and atopy.

abstract：BACKGROUND:There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS:MEDLINE was searched for articles re...

journal_title：Allergy

authors： O'Connell EJ

更新日期：2004-08-01 00:00:00

abstract：:During the last few years, an impressive amount of experimental studies and clinical trials have dealt with a variety of distinct topics in allergic skin diseases - especially atopic dermatitis. In this update, we discuss selected recent data that provide relevant insights into clinical and pathophysiological aspects ...

journal_title：Allergy

authors： Wollenberg A,Feichtner K

更新日期：2013-12-01 00:00:00

abstract：:In a double blind study, alcohol/onion extract (5% ethanol) was injected simultaneously with 20 IU and 200 IU rabbit anti-human-IgE intradermally in 12 adult volunteers (6 atopics, 6 non-atopics). Diameters of wheals and flares were measured 10 min after and compared with control sites challenged with 20 IU and 200 IU...

journal_title：Allergy

authors： Dorsch W,Ring J

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:While immediate-type clinical reactions to food can quite easily be identified by history or measurement of specific IgE in combination with positive oral food challenges, the evaluation of food allergy in the absence of immediate clinical reactions still presents diagnostic difficulties--particularly in chi...

journal_title：Allergy

authors： Niggemann B,Reibel S,Wahn U

更新日期：2000-03-01 00:00:00

abstract：:The yeast Pityrosporum orbiculare (P. orbiculare) is a member of the normal human cutaneous flora, but it is also associated with several clinical manifestations of the skin. We have previously observed IgE-binding components in P. orbiculare extracts, using sera from patients with atopic dermatitis. In the present st...

journal_title：Allergy

authors： Zargari A,Härfast B,Johansson S,Johansson SG,Scheynius A

更新日期：1994-01-01 00:00:00

abstract：:Indoor allergens are likely to be direct environmental causes of asthma and mite exposure, and sensitization is the most important environmental risk factor for childhood asthma in temperate zones. Analagous to occupational asthma, allergen avoidance in asthmatic children sensitized and exposed to mite allergens is as...

journal_title：Allergy

authors： Boner A,Pescollderungg L,Silverman M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...

journal_title：Allergy

authors： Sullivan SD,Wenzel SE,Bresnahan BW,Zheng B,Lee JH,Pritchard M,Kamath TV,Weiss ST,TENOR Study Group.

更新日期：2007-06-01 00:00:00

abstract：:We observed two cases of maculopapular eruption occurring 12-72 h after the administration of aminocaproic acid (ACA). Patch tests performed with ACA were positive. Clinical and allergologic patterns suggest the type IV mechanism of hypersensitivity. We present what we believe are the first two cases described of hype...

journal_title：Allergy

authors： González Gutiérrez ML,Esteban López MI,Ruíz Ruíz MD

更新日期：1995-09-01 00:00:00

abstract：:We developed an antigen- and isotype-specific ELISA for the rapid detection of native serum immune complexes (IC). It is a sandwich assay, in which a solid phase antigen-specific capture antibody selectively binds the antigen-specific IC via the antigen. The isotype of the bound IC is then identified using an enzyme-l...

journal_title：Allergy

authors： Bell SJ,Potter PC

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Because little is known about the effects of asthma and asthma therapy on lipid and protein metabolism, we have investigated the characteristics of diet and plasma/serum levels of fat and protein in a group of asthma patients with various degrees of severity. METHODS:A case-control study was carried out on ...

journal_title：Allergy

authors： Picado C,Deulofeu R,Lleonart R,Agustí M,Casals E,Quintó L,Mullol J

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Patch testing is the standard clinical procedure to prove contact sensitization. It is a common practice to attach multiple patch tests at the same time. However, synchronous reactions to unrelated allergens may not be completely unassociated. If so, the reaction in a given test field might be influenced by ...

journal_title：Allergy

authors： Brasch J,Geier J,Schnuch A,Uter W,German Contact Dermatitis Research Group (DKG).,Information Network of Departments of Dermatology (IVDK).

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Local application of allergen extracts in specific immunotherapy is accompanied by increased compliance and significantly reduced side effects. However, efficacy of local immunotherapy in children has yet not been sufficiently demonstrated. This study was performed to determine clinical efficacy of high dose...

journal_title：Allergy

authors： Bufe A,Ziegler-Kirbach E,Stoeckmann E,Heidemann P,Gehlhar K,Holland-Letz T,Braun W

更新日期：2004-05-01 00:00:00

abstract：:In order to establish reference values for total serum IgE in an adult non-atopic population, 175 individuals, 17-85 years of age, were investigated. The usefulness of a sensitive method (PRIST) for serum IgE determinations in discriminating atopy from non-atopic conditions in allergological routine diagnosis was eluc...

journal_title：Allergy

authors： Zetterström O,Johansson SG

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS:In a prospecti...

journal_title：Allergy

authors： Mösges R,Koch AF,Raskopf E,Singh J,Shah-Hosseini K,Astvatsatourov A,Hauswald B,Yarin Y,Corazza F,Haazen L,Pirotton S,Allekotte S,Zadoyan G,Legon T,Durham SR,Shamji MH

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Variable airflow obstruction and airway hyperresponsiveness (AHR) are features of asthma, which are absent in nonasthmatic eosinophilic bronchitis (EB). Airway remodelling is characteristic of both conditions suggesting that remodelling and airway dysfunction are disassociated, but whether the airway geometr...

journal_title：Allergy

authors： Siddiqui S,Gupta S,Cruse G,Haldar P,Entwisle J,Mcdonald S,Whithers PJ,Hainsworth SV,Coxson HO,Brightling C

更新日期：2009-06-01 00:00:00

abstract：:Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti-allergic drug, on bronchoconstri...

journal_title：Allergy

authors： Kurashima K,Fujimura M,Saito M,Sakamoto S,Miyake Y,Nishi K,Matsuda T

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the use of omega 3 and omega 6 supplementation for the prevention of allergic diseases. We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders. METHODS:We searched ...

journal_title：Allergy

authors： Anandan C,Nurmatov U,Sheikh A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Buckwheat flour (BF) is known as a potent food allergen. Sensitization to it usually occurs by ingestion but also by inhalation in occupational or domestic exposure. Buckwheat chaff-stuffed pillows (BCP) can be contaminated with BF during the process of pilling, and many Korean children and adults use BCP fo...

journal_title：Allergy

authors： Lee SY,Lee KS,Hong CH,Lee KY

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for...

journal_title：Allergy

authors： Logan CA,Brandt S,Wabitsch M,Brenner H,Wiens F,Stahl B,Marosvölgyi T,Decsi T,Rothenbacher D,Genuneit J

更新日期：2017-09-01 00:00:00

abstract：:The efficacy of single-allergen-specific immunotherapy in polysensitized subjects is a matter of debate. We therefore performed a post hoc analysis of pooled data from six randomized, double-blind, placebo-controlled trials (N = 1871) comparing the efficacy and safety of the SQ-standardized grass allergy immunotherapy...

journal_title：Allergy

authors： Nelson H,Blaiss M,Nolte H,Würtz SØ,Andersen JS,Durham SR

更新日期：2013-02-01 00:00:00

abstract：:Delayed hypersensitivity to rubber chemicals is well known, but there are only a limited number of case reports on an immediate type of hypersensitivity inducing contact urticaria. We have recently seen several patients with rubber glove-induced contact urticaria who have had both positive skin prick tests and positiv...

journal_title：Allergy

authors： Axelsson JG,Johansson SG,Wrangsjö K

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:So far the issue of patch tests with mite allergens in subjects not affected by atopic dermatitis (AD) has been poorly investigated. The aim of this study was to assess the frequency and intensity of responses to atopy patch tests with Dermatophagoides in non-AD subjects, and to compare them to the ones obse...

journal_title：Allergy

authors： Seidenari S,Giusti F,Pellacani G,Bertoni L

更新日期：2003-05-01 00:00:00

abstract：:Children with recurrent lower respiratory tract infection (RLRI) may respond poorly to polysaccharide antigens. To examine how such children respond to a polysaccharide coupled to a protein carrier, we immunized 15 children with RLRI aged 8-69 months and 15 carefully age-matched healthy controls once with a Haemophilu...

journal_title：Allergy

authors： Kristensen K,Barington T,Pressler T,Heilmann C

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. METHODS:We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-...

journal_title：Allergy

authors： Ruokolainen L,Parkkola A,Karkman A,Sinkko H,Peet A,Hämäläinen AM,von Hertzen L,Tillmann V,Koski K,Virtanen SM,Niemelä O,Haahtela T,Knip M

更新日期：2020-09-01 00:00:00

abstract：:This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...

journal_title：Allergy

authors： Savolainen J,Kortekangas-Savolainen O,Nermes M,Viander M,Koivikko A,Kalimo K,Terho EO

更新日期：1998-05-01 00:00:00

abstract：:House-dust mites are a major source of allergens. Beds are often heavily infested. It is conceivable that, during the winter period in temperate climates, the ambient indoor air is too dry for their survival, but that mites can still survive in beds where the humidity is raised when the bed is occupied. To investigate...

journal_title：Allergy

authors： de Boer R,Kuller K

更新日期：1997-03-01 00:00:00

abstract：:The levels of peripheral-blood, naturally occurring aliphatic polyamines, such as putrescine, spermidine, and spermine, from 21 bronchial asthmatic patients (11 atopics and 10 nonatopics) were measured by postcolumn derivatization high-performance liquid chromatography analysis. None of the patients, except the 44-yea...

journal_title：Allergy

authors： Kurosawa M,Shimizu Y,Tsukagoshi H,Ueki M

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Polcalcins are pollen-specific allergens with two EF-hand calcium-binding sites that exhibit strong cross-reactivity. Our objective was to isolate and express the cDNA coding of the EF-hand calcium-binding allergen from lilac pollen and to study cross-reactivity with other polcalcins from related and nonrela...

journal_title：Allergy

authors： Ledesma A,Barderas R,Westritschnig K,Quiralte J,Pascual CY,Valenta R,Villalba M,Rodríguez R

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：:Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to asthma, allergies, and allied diseases. Prostaglandins and leukotrienes are the most studied eicosanoids and established inducers of air...

journal_title：Allergy

authors： Sokolowska M,Rovati GE,Diamant Z,Untersmayr E,Schwarze J,Lukasik Z,Sava F,Angelina A,Palomares O,Akdis CA,O'Mahony L,Sanak M,Dahlen SE,Woszczek G

更新日期：2021-01-01 00:00:00