Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis.

Abstract:

:Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.

journal_name

Allergy

journal_title

Allergy

authors

Pezato R,Świerczyńska-Krępa M,Niżankowska-Mogilnicka E,Derycke L,Bachert C,Pérez-Novo CA

doi

10.1111/all.12010

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1347-56

issue

11

eissn

0105-4538

issn

1398-9995

journal_volume

67

pub_type

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