Abstract:
BACKGROUND:The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway inflammation is unknown. OBJECTIVES:This study investigated whether allergen-induced airway inflammation involves an impaired local AM response. METHODS:Airway AM expression was measured in acute and chronically sensitized mice following allergen inhalation and in airway epithelial cells of asthmatic and nonasthmatic patients. The effects of AM on experimental allergen-induced airway inflammation and of AM on lung epithelial repair in vitro were investigated. RESULTS:Adrenomedullin mRNA levels were significantly (P < 0.05) reduced in acute ovalbumin (OVA)-sensitized mice after OVA challenge, by over 60% at 24 h and for up to 6 days. Similarly, reduced AM expression was observed in two models of chronic allergen-induced inflammation, OVA- and house dust mite-sensitized mice. The reduced AM expression was restricted to airway epithelial and endothelial cells, while AM expression in alveolar macrophages was unaltered. Intranasal AM completely attenuated the OVA-induced airway hyperresponsiveness and mucosal plasma leakage but had no effect on inflammatory cells or cytokines. The effects of inhaled AM were reversed by pre-inhalation of the putative AM receptor antagonist, AM ((22-52)) . AM mRNA levels were significantly (P < 0.05) lower in human asthmatic airway epithelial samples than in nonasthmatic controls. In vitro, AM dose-dependently (10(-11) -10(-7) M) accelerated experimental wound healing in human and mouse lung epithelial cell monolayers and stimulated epithelial cell migration. CONCLUSION:Adrenomedullin suppression in T(H) 2-related inflammation is of pathophysiological significance and represents loss of a factor that maintains tissue integrity during inflammation.
journal_name
Allergyjournal_title
Allergyauthors
Hagner S,Welz H,Kicic A,Alrifai M,Marsh LM,Sutanto EN,Ling KM,Stick SM,Müller B,Weissmann N,Renz Hdoi
10.1111/j.1398-9995.2012.02851.xsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
998-1006issue
8eissn
0105-4538issn
1398-9995journal_volume
67pub_type
杂志文章相关文献
ALLERGY文献大全abstract::Sera from 425 patients were analysed with Phadebas RAST reagents against a panel of 19 allergens and the most commonly positive results were to grass pollen, Dermatophagoides pteronyssinus and cat epithelium. Of the 275 sera RAST-positive to any allergen, 261 were positive by a RAST technique which used a mixture of t...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1980.tb01796.x
更新日期:1980-09-01 00:00:00
abstract::We describe two uncommon cases of oral allergy syndrome (OAS) after eating pistachio nuts (p.n.) in subjects (a 54-year-old man and a 3-year-old girl) with exclusive skin prick test (SPT) positivity to Parietaria (P.) and pistachio nut (p.n.) allergens. Serologic P.- and p.n.-specific IgE determinations were also carr...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1996.tb04493.x
更新日期:1996-12-01 00:00:00
abstract::A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb02661.x
更新日期:1994-04-01 00:00:00
abstract::PVG rats given injections of 1 microgram ovalbumin (OA) together with 10 mg Silica gel failed to provide serosal mast cells or lung tissue with the capacity to release histamine on in vitro challenge with the antigen. However, if such animals were injected i.p. with 100 mg of alum (without any further antigen addition...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1983.tb01618.x
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:The diagnosis of allergic reactions to drugs is difficult. Most skin tests are not standardized, and in vitro tests are needed to avoid provocation tests. Cross-linking of IgE on basophils is known to cause the release of both cysteinyl leukotriene (Cys-LT) and histamine. We aimed to evaluate the diagnostic ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.00103.x
更新日期:2001-07-01 00:00:00
abstract::All eight production workers from a small trout-processing factory were studied because of respiratory or rhinitis symptoms when working next to the automatic gutting machine. Seven of the eight had positive histamine provocation tests. Four patients had elevated total IgE levels while one had a slightly elevated eosi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1989.tb00455.x
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Undernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-spe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02829.x
更新日期:2012-06-01 00:00:00
abstract::The diagnosis of allergic reactions in clinical practice is based on both clinical history and the determination of specific immunoglobulin E (IgE), either in the serum or on skin mast cells. However, for various reasons, identification of the causative factors is not possible in all the cases. Moreover, not all aller...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1034/j.1398-9995.2003.00253.x
更新日期:2003-07-01 00:00:00
abstract::Type I allergy against some common microorganisms was investigated in 14 patients with AIDS and 11 human immunodeficiency virus (HIV) antibody-positive homosexual men, and in a control group consisting of 13 heterosexual men without HIV antibodies. Basophil histamine release technique was used as a sensitive method to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb02212.x
更新日期:1987-05-01 00:00:00
abstract::Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including geneti...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12126
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of ato...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12309
更新日期:2014-02-01 00:00:00
abstract::The study aimed to determine whether occupational contact urticaria and symptoms of mucous membranes, reported by five workers in a cactus nursery, were due to IgE-mediated allergy to Schlumbergera cacti. The five persons had positive skin prick tests to the plants as is and positive histamine-release tests, and in th...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb01045.x
更新日期:1997-06-01 00:00:00
abstract::A safe food supply is a legitimate expectation of consumers, which the food industry must meet. Allergic reactions to food are recognised as a significant public health problem. Protecting allergic consumers against such reactions, while minimising the impact of food allergy on their quality of life, poses a challenge...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.00928.x
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:We report on a 37-year-old man without history of previous allergic disease who developed an aseptic intolerance reaction to a chromium-cobalt alloy, with local discomfort, loosening, and absence of fracture healing. Both in vivo and in vitro allergoimmunologic diagnostic tests were performed. METHODS:Patch...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00619.x
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:We report on a 21-year-old atopic woman who developed urticaria, angioedema of the face, and wheezy dyspnea shortly after drinking beer and after eating a corn-made snack. METHODS:Skin prick tests and specific IgE determinations to beer ingredients and cereal extracts were performed. Immunoblotting inhibiti...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00827.x
更新日期:1999-06-01 00:00:00
abstract::Children with recurrent lower respiratory tract infection (RLRI) may respond poorly to polysaccharide antigens. To examine how such children respond to a polysaccharide coupled to a protein carrier, we immunized 15 children with RLRI aged 8-69 months and 15 carefully age-matched healthy controls once with a Haemophilu...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1995.tb01192.x
更新日期:1995-06-01 00:00:00
abstract::MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12880
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The presence of anti-FcepsilonRI and anti-IgE autoantibodies in a subset of patients with chronic urticaria suggests their aetiopathogenetic role. In clinical practice, the presence of these antibodies is usually considered when the autologous serum skin test (ASST) is positive. AIMS:To evaluate if the posi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00673.x
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Since 1988, numerous allergen immunotherapy guidelines (AIT-GLs) have been developed by national and international organizations to guide physicians in AIT. Even so, AIT is still severely underused. OBJECTIVE:To evaluate AIT-GLs with AGREE-II, developed in 2010 by McMaster University methodologists to compr...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13316
更新日期:2018-03-01 00:00:00
abstract::Taxonomy provides the basis for the identity of species, allowing the construction of keys and the reliable, reproducible identification of dust mites for ecologic purposes and other studies. Details are given of nomenclatorial conventions in taxonomy as applied to dust mites, and taxonomically problematic entities ar...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.1998.tb04989.x
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental asthma. METHODS:ADAM10 was blocked either by using mice with a B-cell-s...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02614.x
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5-nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and ornidazole and to determine possib...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14542
更新日期:2020-08-05 00:00:00
abstract::IgG-binding to the surface of Langerhans cells (LC) is a feature of primary Sjögren's syndrome and might be associated with qualitative and quantitative defects in LC. Fifteen patients with primary Sjögren's syndrome and 15 healthy controls had a punch biopsy performed from clinically unaffected skin. LC were enumerat...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1986.tb00323.x
更新日期:1986-08-01 00:00:00
abstract::Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent in...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14624
更新日期:2020-10-09 00:00:00
abstract::The presence of viable mold propagules in house dust was investigated by 10 different analytic methods, in order to determine to what extent different results are obtained when different analytic methods are used. Moreover, the value of this measurement as an estimator of the potential exposure to fungi in epidemiolog...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb01125.x
更新日期:1994-08-01 00:00:00
abstract::This study evaluated the risk factors for developing allergic reactions to alternative drugs such as acetaminophen and nimesulide in 367 patients intolerant of nonsteroidal anti-inflammatory drugs (NSAID) compared to 243 healthy controls. All subjects were given test doses (TD) of acetaminophen and nimesulide, and age...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03995.x
更新日期:1998-09-01 00:00:00
abstract::Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide eviden...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12662
更新日期:2015-09-01 00:00:00
abstract::We investigated the proliferative response of lymphocytes from mite-sensitive patients (RAST D.far greater than 3.5 PRU/ml) in the presence of the major allergen Der.f.I purified from Dermatophagoides farinae. Comparative studies were carried out with peripheral blood mononuclear cells from non-atopic donors (RAST = 0...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb00409.x
更新日期:1988-02-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosano...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12010
更新日期:2012-11-01 00:00:00
abstract::There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12390
更新日期:2014-06-01 00:00:00