Abstract:
BACKGROUND:Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross-reactivity, which explains this observed co-sensitization. Therefore, the purpose of this study was to explore the relationship between Ole e 7 and Pru p 3. METHODS:A total of 48 patients sensitized to Ole e 7 and/or Pru p 3 were included in the study. Specific IgE serum levels were measured by ImmunoCAP 250 and ELISA. Inhibition assays were performed to determine the existence of cross-reactivity between both nsLTPs. Allergic response was analyzed ex vivo (basophil activation test) and in vitro (RBL-2H3 mast cell model). RESULTS:Common IgG and IgE epitopes were identified between both allergens. IgE-binding inhibition was detected in Ole e 7-monosensitized patients using rPru p 3 as inhibitor, reaching inhibition values of 25 and 100%. Ex vivo and in vitro assays revealed a response against rPru p 3 in four (31%) Ole e 7-monosensitized patients. CONCLUSIONS:Our results suggest that Ole e 7 could play a new role as primary sensitizer in regions with high olive pollen exposure, leading to the peach nsLTP sensitization. This co-sensitization process would occur because of the cross-reactivity between Ole e 7 and Pru p 3 observed in some allergic patients.
journal_name
Allergyjournal_title
Allergyauthors
Oeo-Santos C,Navas A,Benedé S,Ruíz-León B,Díaz-Perales A,Vogel L,Moreno-Aguilar C,Jurado A,Villalba M,Barderas Rdoi
10.1111/all.14086subject
Has Abstractpub_date
2020-04-01 00:00:00pages
798-807issue
4eissn
0105-4538issn
1398-9995journal_volume
75pub_type
杂志文章相关文献
ALLERGY文献大全abstract:BACKGROUND:The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine expression by eosinophils in differe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02694.x
更新日期:2011-11-01 00:00:00
abstract::In analogy with findings from animal experiments, people with low glutathione-peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1986.tb00273.x
更新日期:1986-01-01 00:00:00
abstract::Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb01910.x
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Food allergy affects approximately 5% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. The mucosal adjuvant cholera toxin induces allergic sensitization to co-administered proteins in mice, while feeding the protein alone induces oral tolerance. Int...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2010.02479.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of ato...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12309
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01844.x
更新日期:2009-04-01 00:00:00
abstract::Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to asthma, allergies, and allied diseases. Prostaglandins and leukotrienes are the most studied eicosanoids and established inducers of air...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14295
更新日期:2021-01-01 00:00:00
abstract::: The use of specific immunotherapy (SIT) for allergic disorders has recently been extended by introduction of a convenient, tablet-based, disease-modifying vaccine against grass pollen allergy. Allergy immunotherapy tablet (AIT) programmes targeting house dust mite and other allergies are currently in late-phase deve...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02644.x
更新日期:2011-07-01 00:00:00
abstract::Histamine is a key mediator in the development of allergy symptoms, and oral H(1)-antihistamines are among the most widely used treatments for symptomatic relief in conditions such as allergic rhinitis and chronic urticaria. Ebastine is a second-generation antihistamine which has been shown to be an effective treatmen...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2008.01897.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Dissecting complex diseases in underlying distinct traits and studying these for their genetic basis might enhance the power as well as the specificity, of detection of disease genes. These phenotypes are known as intermediate phenotypes. OBJECTIVE:We were interested in the atopic basis of asthma, and used ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00646.x
更新日期:2005-02-01 00:00:00
abstract::The presence of viable mold propagules in house dust was investigated by 10 different analytic methods, in order to determine to what extent different results are obtained when different analytic methods are used. Moreover, the value of this measurement as an estimator of the potential exposure to fungi in epidemiolog...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb01125.x
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.056002175.x
更新日期:2001-02-01 00:00:00
abstract::The mucosal plasma exudate with its proteins, enzymes, derived peptides, and matrix molecules is an important factor in inflammatory airway diseases. This study investigated whether topical glucocorticosteroid treatment influences mucosal exudation of bulk plasma (fibrinogen) and the generation of plasma-derived media...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1994.tb00822.x
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Quantitative ELISA kits used for the measurement of indoor allergens are time-consuming. Therefore, an immunodot assay (Dustscreen) has been introduced, so that results can be obtained within 4 h. In order to assess the potential applications of the new method, we compared quantitative ELISA methods and Dust...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.00117.x
更新日期:2001-10-01 00:00:00
abstract::We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation b...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12955
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The cytokine network is thought to be essential in orchestrating airway inflammation in asthma. Although evidence has accumulated to suggest that atopic asthma is a Th2 disease, much less is known about nonatopic asthma. METHODS:We have compared the production of IL-4, IL-6, IFN-gamma, and TNF-alpha from pe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00711.x
更新日期:2000-12-01 00:00:00
abstract::Hymenoptera venom allergy occasionally causes fatal reactions. The prevalence of systemic reactions (SRs) is 0.3-8.9%, with anaphylaxis in 0.3-42.8% of cases. Factors contributing to reaction severity include older age, insect type, a previous less severe SR, preexisting diseases, concomitant treatments, mast cell dis...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02630.x
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01889.x
更新日期:2009-05-01 00:00:00
abstract::Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2007.01336.x
更新日期:2007-03-01 00:00:00
abstract::We studied the allergen composition in an extract of the storage mite Lepidoglyphus destructor. Monoclonal antibodies (mAbs) were raised against L. destructor by a standard hybridoma technique. In the subsequent screening, we concentrated on mAbs fulfilling three criteria. First, in ELISA, mAbs were assessed against a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb00129.x
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Improving quality of life is considered to be a major endpoint and motivation for clinical intervention in patients with perennial allergic rhinitis (PAR). In addition to classical symptoms of congestion, pruritus, and rhinorrhea, patients will often complain of not being able to sleep well at night and of f...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.2003.00093.x
更新日期:2003-05-01 00:00:00
abstract::The presence of indoor allergens in Finnish homes was studied for the first time. Dust samples (n = 30) were collected by vacuuming a 1 m2 area from a living-room carpet in 30 apartments divided into three groups: homes with cats (n = 10), homes with dogs (n = 10), and homes without pets (n = 10). The levels of major ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb03870.x
更新日期:1998-02-01 00:00:00
abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1990.tb00466.x
更新日期:1990-02-01 00:00:00
abstract::Environmental exposures in pregnancy and the early postnatal period affect early immune development. Early immune function and future allergy susceptibility appear to result from a combination of maternal phenotype, infant genotype, and environmental exposures in utero that affect early gene expression. Furthermore, e...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02620.x
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. METHODS:Baseline pati...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1398-9995.2006.01254.x
更新日期:2007-02-01 00:00:00
abstract::Anaphylaxis is a growing paediatric clinical emergency that is difficult to diagnose because a consensus definition was lacking until recently. Many European countries have no specific guidelines for anaphylaxis. This position paper prepared by the EAACI Taskforce on Anaphylaxis in Children aims to provide practical g...
journal_title:Allergy
pub_type: 杂志文章,实务指引
doi:10.1111/j.1398-9995.2007.01421.x
更新日期:2007-08-01 00:00:00
abstract::In a study of 770 patients with allergic rhinitis, anamnestic data were collected by means of a questionnaire. 484 (63%) of the patients were women and 286 (37%) men. 45.5% of the patients had perennial symptoms, 33.5% had seasonal symptoms only, and 21% had predominantly seasonal but also some perennial symptoms. Mor...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1982.tb02317.x
更新日期:1982-08-01 00:00:00
abstract::In studies on atopic dermatitis (AD), different scoring systems are used to evaluate the severity of the disease. The objective of this study was to investigate agreement between observers in the assessment of the overall severity of AD, and interobserver variation in the assessment of severity of AD for each scoring ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb01255.x
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Mould-attributed symptoms have included features which overlap with unexplained syndromes such as sick building syndrome. OBJECTIVES:We describe questionnaire and chart review findings in patients following exposure to moulds which include Stachybotrys and compare responses with two control groups. METHODS...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.02157.x
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:There is strong evidence that reduced exposures to microbial compounds triggering innate immune responses early in life are critical for the development of allergic illnesses. The underlying mechanisms remain unknown, but will include T-cell responses either along T helper type 1 (Th1)/Th2 pathways or via T ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01685.x
更新日期:2008-11-01 00:00:00