Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

abstract：:In this study, we investigated the role of calcium and phospholipid-dependent protein kinase (protein kinase C, PKC) in the modulation of histamine release from human basophils. A novel and potent inhibitor of PKC, K-252a, inhibited the release of histamine induced by anti-IgE in a dose-dependent manner with ID50 (the...

journal_title：Allergy

authors： Morita Y,Takaishi T,Honda Z,Miyamoto T

更新日期：1988-02-01 00:00:00

abstract：:CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against...

journal_title：Allergy

authors： Cosmi L,Liotta F,Maggi E,Romagnani S,Annunziato F

更新日期：2011-08-01 00:00:00

abstract：:Delayed-type, T cell-mediated, drug hypersensitivity reactions are a serious unwanted manifestation of drug exposure that develops in a small percentage of the human population. Drugs and drug metabolites are known to interact directly and indirectly (through irreversible protein binding and processing to the derived ...

journal_title：Allergy

authors： Naisbitt DJ,Olsson-Brown A,Gibson A,Meng X,Ogese MO,Tailor A,Thomson P

更新日期：2020-04-01 00:00:00

abstract：:Climate therapy has been used for decades in the treatment of atopic dermatitis (AD), but evidence of its effectiveness has not yet been assessed systematically. A systematic literature search in Medline, Embase, and the Cochrane library was performed to identify all original studies concerning alpine climate treatmen...

journal_title：Allergy

authors： Fieten KB,Weststrate AC,van Zuuren EJ,Bruijnzeel-Koomen CA,Pasmans SG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Allergic diseases are more common in Finland than in Estonia, which-according to the biodiversity hypothesis-could relate to differences in early microbial exposures. METHODS:We aimed at defining possible microbial perturbations preceding early atopic sensitization. Stool, nasal and skin samples of 6-month-...

journal_title：Allergy

authors： Ruokolainen L,Parkkola A,Karkman A,Sinkko H,Peet A,Hämäläinen AM,von Hertzen L,Tillmann V,Koski K,Virtanen SM,Niemelä O,Haahtela T,Knip M

更新日期：2020-09-01 00:00:00

abstract：:A young woman (26 years old), with gastrointestinal candidosis of 8 months duration, was hospitalized in our department to study her cell immunity. Five minutes after an id injection of PHA (bactophytohaemoagglutinin M, Difco, 1 mg), mix monilieae, mix tricophyton and PPD Berna, she showed an extensive wheal and flare...

journal_title：Allergy

authors： Schiavino D,Nucera E,Murzilli F,Schinco G,Papa G,Fais G,Patriarca G

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Bronchial asthma is a chronic disease characterized by inflammation, obstruction, and hyperresponsiveness of the airways. There is currently no curative therapy for asthma. Type 2 helper T cell response plays a critical role in the pathogenesis of the disease. Protein S is a glycoprotein endowed with anticoa...

journal_title：Allergy

authors： Asayama K,Kobayashi T,D'Alessandro-Gabazza CN,Toda M,Yasuma T,Fujimoto H,Okano T,Saiki H,Takeshita A,Fujiwara K,Fridman D'Alessandro V,Nishihama K,Totoki T,Inoue R,Takei Y,Gabazza EC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The reasons for the rise in asthma and allergies remain unclear. To identify risk or protective factors, it is essential to carry out longitudinal epidemiological studies, preferably birth cohort studies. In Europe, several birth cohort studies on asthma and atopic diseases have been initiated over the last ...

journal_title：Allergy

authors： Keil T,Kulig M,Simpson A,Custovic A,Wickman M,Kull I,Lødrup Carlsen KC,Carlsen KH,Smit HA,Wijga AH,Schmid S,Berg A,Bollrath C,Eller E,Bindslev-Jensen C,Halken S,Høst A,Heinrich J,Porta D,Forastiere F,Brunekreef B

更新日期：2006-02-01 00:00:00

abstract：:Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...

journal_title：Allergy

authors： Shoda T,Futamura K,Kobayashi F,Saito H,Matsumoto K,Matsuda A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma. In mice, this region harbors a locus control region for nearby TH 2 cytokines, which is characterized by four Rad50 DNase I hypersensitive sites (RHS4...

journal_title：Allergy

authors： Schieck M,Sharma V,Michel S,Toncheva AA,Worth L,Potaczek DP,Genuneit J,Kretschmer A,Depner M,Dalphin JC,Riedler J,Frei R,Pekkanen J,Tost J,Kabesch M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Whereas recent studies underlie the fundamental importance of the CC chemokine receptor 3 (CCR3) for the recruitment of eosinophils in allergic diseases, controversial data exist about the relevance of CCR1 on eosinophils. Therefore, the purpose of this study was to investigate the expression and regulation ...

journal_title：Allergy

authors： Elsner J,Dulkys Y,Gupta S,Escher SE,Forssmann WG,Kapp A,Forssmann U

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:It is commonly acknowledged that asthma is exacerbated by viral infections. On the other hand, basophil infiltration of lung tissues has been evidenced postmortem in cases of fatal disease, raising the question of a possible link between these two observations. OBJECTIVES:Herein, we addressed the relationsh...

journal_title：Allergy

authors： Ramadan A,Pham Van L,Machavoine F,Dietrich C,Alkan M,Karasuyama H,Schneider E,Dy M,Thieblemont N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, P...

journal_title：Allergy

authors： Oeo-Santos C,Navas A,Benedé S,Ruíz-León B,Díaz-Perales A,Vogel L,Moreno-Aguilar C,Jurado A,Villalba M,Barderas R

更新日期：2020-04-01 00:00:00

abstract：:The presence of indoor allergens in Finnish homes was studied for the first time. Dust samples (n = 30) were collected by vacuuming a 1 m2 area from a living-room carpet in 30 apartments divided into three groups: homes with cats (n = 10), homes with dogs (n = 10), and homes without pets (n = 10). The levels of major ...

journal_title：Allergy

authors： Raunio P,Pasanen AL,Reiman M,Virtanen T

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...

journal_title：Allergy

authors： Simon MR,Mulla ZD

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the comp...

journal_title：Allergy

authors： Jensen RK,Jabs F,Miehe M,Mølgaard B,Pfützner W,Möbs C,Spillner E,Andersen GR

更新日期：2020-08-01 00:00:00

abstract：:A simple microtiter assay for eosinophil activation is described. The assay used 1000-4000 eosinophils/microtiter well, and the design allows for a separate or simultaneous quantitative assessment of eosinophil adhesion to protein-coated microtiter wells and degranulation after stimulation with eosinophil-activating f...

journal_title：Allergy

authors： Reimert CM,Skov PS,Poulsen LK

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Physicians typically rely heavily on self-reported symptoms to make a diagnosis of exercise-induced bronchoconstriction (EIB). However, in elite sport, respiratory symptoms have poor diagnostic value. In 2009, following a change in international sports regulations, all elite athletes suspected of asthma and/...

journal_title：Allergy

authors： Ansley L,Kippelen P,Dickinson J,Hull JH

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Vernal keratoconjunctivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficacious treatment. The aims of the study were to determine quantities and distribution of Hsp chaperones in the conjunctiva of VKC patients and assess their levels in conjunctival epithelial an...

journal_title：Allergy

authors： Leonardi A,Tarricone E,Corrao S,Alaibac M,Corso AJ,Zavan B,Venier P,Conway de Macario E,Macario AJ,Di Stefano A,Cappello F,Brun P

更新日期：2016-03-01 00:00:00

abstract：:Exposure to natural rubber latex (NRL) medical gloves poses risks to patients sensitized to NRL and to users of protective gloves. Previous studies have shown that extractable allergen levels of the gloves vary widely. Since most of the available laboratory methods of NRL allergen measurement lack adequate validation,...

journal_title：Allergy

authors： Palosuo T,Mäkinen-Kiljunen S,Alenius H,Reunala T,Yip E,Turjanmaa K

更新日期：1998-01-01 00:00:00

abstract：:Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. ...

journal_title：Allergy

authors： Moll B,Klimek L,Eggers G,Mann W

更新日期：1998-03-01 00:00:00

abstract：:A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot t...

journal_title：Allergy

authors： Taudorf E,Bundgaard A,Fagerström PO,Weeke E,Weeke B

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：:Asthma is a generalized term that describes a scope of distinct pathologic phenotypes of variable severity, which share a common complication of reversible airflow obstruction. Asthma is estimated to affect almost 400 million people worldwide, and nearly ten percent of asthmatics have what is considered "severe" disea...

journal_title：Allergy

authors： Perkins TN,Donnell ML,Oury TD

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...

journal_title：Allergy

authors： Savilahti R,Uitti J,Roto P,Laippala P,Husman T

更新日期：2001-02-01 00:00:00

abstract：:The leading priority for the Polish Presidency of the Council of the European Union was to reduce health inequalities across European societies, and, within its framework, prevention and control of respiratory diseases in children. This very important paper contain proposal of international cooperation on the preventi...

journal_title：Allergy

authors： Samoliński B,Fronczak A,Kuna P,Akdis CA,Anto JM,Bialoszewski AZ,Burney PG,Bush A,Czupryniak A,Dahl R,Flood B,Galea G,Jutel M,Kowalski ML,Palkonen S,Papadopoulos N,Raciborski F,Sienkiewicz D,Tomaszewska A,Von Mutius

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Exposure and contact with bee moth (Galleria mellonella) larvae (Gm) can cause an allergic reaction both in anglers and breeders. We described the case of an amateur fisherman who experienced an allergic reaction using Gm but not using heat-treated Gm (h-Gm) (mummies). The aim of this study was to demonstrat...

journal_title：Allergy

authors： Villalta D,Martelli P,Mistrello G,Roncarolo D,Zanoni D

更新日期：2004-09-01 00:00:00

abstract：:For screening atopy risk in 6401 (84%) of all infants born during the year 1990 in six obstetric departments of five German cities, cord-blood IgE values were determined with CAP-RAST-FEIA. After cases with elevated IgA values had been excluded, 25% of the values were above the detection limit of 0.35 kU/l, and 8.5% w...

journal_title：Allergy

authors： Bergmann RL,Schulz J,Günther S,Dudenhausen JW,Bergmann KE,Bauer CP,Dorsch W,Schmidt E,Luck W,Lau S

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Management of atopic dermatitis (AD) requires judging the symptoms of local skin lesions and prescribing a suitable treatment. However, no method has been established in which objective measures can be used to evaluate the severity of local symptoms. We established a method for measuring thymus and activatio...

journal_title：Allergy

authors： Morita E,Takahashi H,Niihara H,Dekio I,Sumikawa Y,Murakami Y,Matsunaka H

更新日期：2010-09-01 00:00:00

abstract：:We studied the effects of anti-asthmatic and anti-inflammatory drugs on antigen-induced bronchial anaphylactic reactions (BAR) in Sprague Dawley (SD) rats immunized with ovalbumin (OA) and alum. The animals were treated locally (intratracheal instillation (i.t.) or by aerosol) with terbutaline (TERB), disodium cromogl...

journal_title：Allergy

authors： Dahlbäck M,Brattsand R

更新日期：1986-11-01 00:00:00