The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy.

Abstract:

BACKGROUND:IgG to galactose-α-1,3-galactose (α-gal) are highly abundant natural antibodies (Ab) in humans. α-Gal-specific IgE Ab cause a special form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat. We investigated 20 patients who experienced such reactions and characterized their α-gal-specific IgE and IgG responses in more detail. METHODS:α-Gal-specific IgE was determined by ImmunoCAP. IgE reactivity to meat extract and bovine gamma globulin (BGG) was assessed by immunoblotting and ELISA, respectively. In some experiments, sera were pre-incubated with α-gal or protein G to deplete IgG Ab. α-Gal-specific IgG1-4 Ab in individuals with and without meat allergy were assessed by ELISA. RESULTS:In immunoblots, BGG was the most frequently recognized meat protein. Binding of IgE and IgG to BGG was confirmed by ELISA and completely abolished after pre-incubation with α-gal. Neither the depletion of autologous α-gal-specific IgG Ab nor the addition of α-gal-specific IgG Ab from nonallergic individuals changed the IgE recognition of BGG of meat-allergic patients. Meat-allergic patients showed significantly higher α-gal-specific IgG1 and IgG3 Ab than nonallergic individuals, whereas the latter showed significantly higher levels of α-gal-specific IgG4 Ab. CONCLUSION:Patients with delayed meat allergy display IgE and IgG Ab that selectively recognize the α-gal epitope on BGG. Their enhanced α-gal-specific IgE levels are accompanied by high levels of α-gal-specific IgG1 devoid of IgE-blocking activity. This subclass distribution is atypical for food allergies and distinct from natural α-gal IgG responses in nonallergic individuals.

journal_name

Allergy

journal_title

Allergy

authors

Kollmann D,Nagl B,Ebner C,Emminger W,Wöhrl S,Kitzmüller C,Vrtala S,Mangold A,Ankersmit HJ,Bohle B

doi

10.1111/all.12948

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

266-273

issue

2

eissn

0105-4538

issn

1398-9995

journal_volume

72

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen.

    abstract:BACKGROUND:Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract. OBJECTIVE:To identify and characterize kirola, the 17-kDa protein of green kiwifruit (Act d 11). METHODS:Act d 11 was purified from green ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2011.02555.x

    authors: D'Avino R,Bernardi ML,Wallner M,Palazzo P,Camardella L,Tuppo L,Alessandri C,Breiteneder H,Ferreira F,Ciardiello MA,Mari A

    更新日期:2011-07-01 00:00:00

  • Cigarette smoke facilitates allergen penetration across respiratory epithelium.

    abstract:BACKGROUND:The association between cigarette smoke exposure and allergic airway disease is a matter for debate. We sought to investigate in an in vitro system whether active smoking reduces the integrity and barrier function of the respiratory epithelium and thus facilitates allergen penetration. METHODS:We cultured t...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01861.x

    authors: Gangl K,Reininger R,Bernhard D,Campana R,Pree I,Reisinger J,Kneidinger M,Kundi M,Dolznig H,Thurnher D,Valent P,Chen KW,Vrtala S,Spitzauer S,Valenta R,Niederberger V

    更新日期:2009-03-01 00:00:00

  • Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model.

    abstract:BACKGROUND:In high-risk populations, allergen-specific prophylaxis could protect from sensitization and subsequent development of allergic disease. However, such treatment might itself induce sensitization and allergies, thus requiring hypoallergenic vaccine formulations. We here characterized the preventive potential ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13573

    authors: Kratzer B,Köhler C,Hofer S,Smole U,Trapin D,Iturri J,Pum D,Kienzl P,Elbe-Bürger A,Gattinger P,Mittermann I,Linhart B,Gadermaier G,Jahn-Schmid B,Neunkirchner A,Valenta R,Pickl WF

    更新日期:2019-02-01 00:00:00

  • Ultrastructural localization of histamine in human basophils and mast cells; changes associated with anaphylactic degranulation and recovery demonstrated with a diamine oxidase-gold probe.

    abstract::Subcellular sites of histamine in purified human lung mast cells and human peripheral blood basophils were determined using a newly developed enzyme-gold affinity method for ultrastructural analysis. The evolving morphologies of regulated secretion and recovery from regulated secretion in each cell showed that granule...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.1997.tb04807.x

    authors: Dvorak AM

    更新日期:1997-01-01 00:00:00

  • Angioedema induced by cardiovascular drugs: new players join old friends.

    abstract::During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin-angiotensin-aldosterone system (RAAS). The majority of angioedema in...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12680

    authors: Bas M,Greve J,Strassen U,Khosravani F,Hoffmann TK,Kojda G

    更新日期:2015-10-01 00:00:00

  • Influenza A virus enhances basophil histamine release and the enhancement is abolished by carbohydrates.

    abstract::Basophil histamine release was studied in leukocyte suspensions from normal individuals and from patients allergic to house dust mite or birch pollen. Mediator release caused by IgE-mediated reactions was examined by stimulating the cells with anti-IgE or specific antigens, and the calcium ionophore A23187 was used fo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1990.tb01099.x

    authors: Clementsen P,Norn S,Kristensen KS,Hannoun C

    更新日期:1990-08-01 00:00:00

  • Allergen-induced mediator release tests.

    abstract::The diagnosis of allergic reactions in clinical practice is based on both clinical history and the determination of specific immunoglobulin E (IgE), either in the serum or on skin mast cells. However, for various reasons, identification of the causative factors is not possible in all the cases. Moreover, not all aller...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1034/j.1398-9995.2003.00253.x

    authors: Demoly P,Lebel B,Arnoux B

    更新日期:2003-07-01 00:00:00

  • Nature and function of gastrointestinal antigen-presenting cells.

    abstract::Antigen-presenting cells (APCs) of the human gut are heterogeneous, including both macrophages, a variety of dendritic cells and B cells. They are found both in gut-associated lymphoid tissue and in the mucosal lamina propria, especially beneath the surface epithelium. APCs have diverse phenotypes and therefore probab...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1034/j.1398-9995.2001.00903.x

    authors: Brandtzaeg P

    更新日期:2001-01-01 00:00:00

  • Aspirin tolerance induced in aspirin-sensitive asthmatics.

    abstract::Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patien...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1984.tb02621.x

    authors: Kowalski ML,Grzelewska-Rzymowska I,Rozniecki J,Szmidt M

    更新日期:1984-04-01 00:00:00

  • Detection of at least one high-molecular-mass, IgE-binding component of the dust mite Lepidoglyphus destructor.

    abstract::We studied the allergen composition in an extract of the storage mite Lepidoglyphus destructor. Monoclonal antibodies (mAbs) were raised against L. destructor by a standard hybridoma technique. In the subsequent screening, we concentrated on mAbs fulfilling three criteria. First, in ELISA, mAbs were assessed against a...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00129.x

    authors: Olsson S,Härfast B,Johansson SG,van Hage-Hamsten M

    更新日期:1994-09-01 00:00:00

  • Asthma, allergic rhinitis and atopic eczema in Finnish children and adolescents.

    abstract::The parents of 3649 Finnish children and adolescents were interviewed in 1980 to evaluate the prevalence of bronchial asthma, allergic rhinitis and atopic dermatitis. The same group was interviewed 6 years later to determine the incidence of new cases of bronchial asthma in the 1980s. Age- and sex-matched samples were...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1991.tb00564.x

    authors: Pöysä L,Korppi M,Pietikäinen M,Remes K,Juntunen-Backman K

    更新日期:1991-04-01 00:00:00

  • Risks of allergic reactions to biotech proteins in foods: perception and reality.

    abstract::In recent years, significant attention has been paid to the use of biotechnology to improve the quality and quantity of the food supply due in part to the projected growth in the world population, plus limited options available for increasing the amount of land under cultivation. Alterations in the food supply induced...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2005.00704.x

    authors: Lehrer SB,Bannon GA

    更新日期:2005-05-01 00:00:00

  • Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study.

    abstract:BACKGROUND:Data are lacking regarding the prevalence of food sensitization and probable food allergy among general population in India. We report the prevalence of sensitization and probable food allergy to 24 common foods among adults from general population in Karnataka, South India. METHODOLOGY:The study was conduc...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12868

    authors: Mahesh PA,Wong GW,Ogorodova L,Potts J,Leung TF,Fedorova O,Holla AD,Fernandez-Rivas M,Clare Mills EN,Kummeling I,Versteeg SA,van Ree R,Yazdanbakhsh M,Burney P

    更新日期:2016-07-01 00:00:00

  • Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease.

    abstract:BACKGROUND:Mould-attributed symptoms have included features which overlap with unexplained syndromes such as sick building syndrome. OBJECTIVES:We describe questionnaire and chart review findings in patients following exposure to moulds which include Stachybotrys and compare responses with two control groups. METHODS...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.02157.x

    authors: Al-Ahmad M,Manno M,Ng V,Ribeiro M,Liss GM,Tarlo SM

    更新日期:2010-02-01 00:00:00

  • House-dust mites and mattresses.

    abstract:BACKGROUND:Despite considerable efforts to develop anti dust mite strategies, surprisingly few studies have evaluated the allergen content in different types of mattresses in everyday use. This study investigated the presence of mite feces (an indicator of mite allergens) in foam and spring mattresses. METHODS:The hom...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.23433.x

    authors: Schei MA,Hessen JO,Lund E

    更新日期:2002-06-01 00:00:00

  • Prevalence of celiac disease in patients with severe food allergy.

    abstract::The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild all...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12692

    authors: Pillon R,Ziberna F,Badina L,Ventura A,Longo G,Quaglia S,De Leo L,Vatta S,Martelossi S,Patano G,Not T,Berti I

    更新日期:2015-10-01 00:00:00

  • The German version of the Chronic Urticaria Quality-of-Life Questionnaire: factor analysis, validation, and initial clinical findings.

    abstract:BACKGROUND:Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q(2)oL) and to provide reference assessments of QoL. METHODS:The...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01920.x

    authors: Młynek A,Magerl M,Hanna M,Lhachimi S,Baiardini I,Canonica GW,Brzoza Z,Kasperska-Zajac A,Rogala B,Zalewska-Janowska A,Zuberbier T,Maurer M

    更新日期:2009-06-01 00:00:00

  • A viral PAMP double-stranded RNA induces allergen-specific Th17 cell response in the airways which is dependent on VEGF and IL-6.

    abstract:BACKGROUND:Innate immune response by a viral pathogen-associated molecular pattern dsRNA modulates the subsequent development of adaptive immune responses. Although virus-associated asthma is characterized by noneosinophilic inflammation, the role of Th17 cell response in the development of virus-associated asthma is s...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02369.x

    authors: Choi JP,Kim YS,Tae YM,Choi EJ,Hong BS,Jeon SG,Gho YS,Zhu Z,Kim YK

    更新日期:2010-10-01 00:00:00

  • Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency.

    abstract:BACKGROUND:Hereditary angioedema (HAE), type I and II, is an autosomal dominant disease with deficiency of functional C1 inhibitor protein causing episodic swellings of skin, mucosa and viscera. HAE is a genetically heterogeneous disease with more than 200 different mutations in the SERPING1 gene. A genotype-phenotype ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02456.x

    authors: Bygum A,Fagerberg CR,Ponard D,Monnier N,Lunardi J,Drouet C

    更新日期:2011-01-01 00:00:00

  • Structural changes in calcium-binding allergens: use of circular dichroism to study binding characteristics.

    abstract:BACKGROUND:Several studies showed that calcium-binding proteins have a fixed place in the spectrum of allergenic substances. Often the binding of a calcium ion induces conformational changes and affects immunoglobulin E-binding to the allergen. Hence, the quantitative characterization of the binding to calcium is of im...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2005.00907.x

    authors: Hebenstreit D,Ferreira F

    更新日期:2005-09-01 00:00:00

  • Evidence for an asthma risk locus on chromosome Xp: a replication linkage study.

    abstract:BACKGROUND:Asthma is a complex genetic disorder characterized by chronic inflammation in the airways. Identification of genetic risk factors for asthma has been complicated due to genetic heterogeneity and influence from environmental risk factors. Despite the fact that multiple genetic linkage studies have been carrie...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01699.x

    authors: Brasch-Andersen C,Møller MU,Haagerup A,Vestbo J,Kruse TA

    更新日期:2008-09-01 00:00:00

  • Four-year stability of Der p I in house dust under simulated domestic conditions in vitro.

    abstract::For almost 4 years, the stability of Der p I was assessed by RAST inhibition in house-dust samples incubated under simulated domestic conditions (5 or 25 degrees C and 75% relative humidity). Der p I concentrations were determined before heating dust samples at 60 degrees C to kill the mites, and at 0, 6, 14, 21, and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb00813.x

    authors: Kort HS,Kniest FM

    更新日期:1994-02-01 00:00:00

  • Comparative immunophenotyping of monocytes from symptomatic and asymptomatic atopic individuals.

    abstract:BACKGROUND:Allergy has at least two components - a genetic predisposition referred to as atopy and the progress from an atopic state to clinically apparent disease. Peripheral blood monocytes are circulating myeloid precursors of antigen-presenting cells. The expression of cell surface proteins on monocytes may therefo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00546.x

    authors: von Bubnoff D,Scheler M,Hinz T,Matz H,Koch S,Bieber T

    更新日期:2004-09-01 00:00:00

  • Influence of acupuncture on type I hypersensitivity itch and the wheal and flare response in adults with atopic eczema - a blinded, randomized, placebo-controlled, crossover trial.

    abstract:BACKGROUND:Itch is a major symptom of allergic skin disease. Acupuncture has been shown to exhibit a significant effect on histamine-induced itch in healthy volunteers. We investigated the effect of acupuncture on type I hypersensitivity itch and skin reaction in a double-blind, randomized, placebo-controlled, crossove...

    journal_title:Allergy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.2009.02284.x

    authors: Pfab F,Huss-Marp J,Gatti A,Fuqin J,Athanasiadis GI,Irnich D,Raap U,Schober W,Behrendt H,Ring J,Darsow U

    更新日期:2010-07-01 00:00:00

  • Bee moth (Galleria mellonella) allergic reactions are caused by several thermolabile antigens.

    abstract:BACKGROUND:Exposure and contact with bee moth (Galleria mellonella) larvae (Gm) can cause an allergic reaction both in anglers and breeders. We described the case of an amateur fisherman who experienced an allergic reaction using Gm but not using heat-treated Gm (h-Gm) (mummies). The aim of this study was to demonstrat...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2004.00446.x

    authors: Villalta D,Martelli P,Mistrello G,Roncarolo D,Zanoni D

    更新日期:2004-09-01 00:00:00

  • A population-based epidemiologic analysis of deaths from anaphylaxis in Florida.

    abstract:BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01737.x

    authors: Simon MR,Mulla ZD

    更新日期:2008-08-01 00:00:00

  • Combined skin prick and patch testing enhances identification of peanut-allergic patients with atopic dermatitis.

    abstract:BACKGROUND:Food atopy patch tests (APTs) are considered a useful tool for the diagnosis of food allergy. Hypersensitivity to peanuts has not been investigated by means of APTs so far. METHODS:APTs and skin prick tests (SPTs) with peanuts were performed in 136 atopic dermatitis (AD) patients. Relevance of positive and ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2003.00153.x

    authors: Seidenari S,Giusti F,Bertoni L,Mantovani L

    更新日期:2003-06-01 00:00:00

  • Determining the negative predictive value of provocation tests with beta-lactams.

    abstract:BACKGROUND:The beta-lactam allergic work-up is mostly standardized. However, the negative predictive value of drug provocation tests is not yet well established. METHOD:A historical-prospective multicentre cohort study was conducted in four centres (one in France, one in Portugal, two in Italy) to assess the negative ...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1398-9995.2009.02228.x

    authors: Demoly P,Romano A,Botelho C,Bousquet-Rouanet L,Gaeta F,Silva R,Rumi G,Rodrigues Cernadas J,Bousquet PJ

    更新日期:2010-03-01 00:00:00

  • Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.

    abstract::The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics and a randomized, d...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1398-9995.1982.tb01884.x

    authors: Svedmyr K,Mellstrand T,Svedmyr N

    更新日期:1982-02-01 00:00:00

  • Cytodestructive mechanisms provoked by food antigens. I. Direct, allergic autocytotoxicity.

    abstract::In vitro challenge of peripheral white blood cells (WBC) from 62 food sensitive patients and 22 asymptomatic control individuals was performed using standardized extract of cow milk, corn and wheat. 81% of the patients reacted at least toward one food antigen, showing disintegration of WBC, as measured by trypan blue ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1985.tb00211.x

    authors: Podleski WK

    更新日期:1985-04-01 00:00:00