Ultrastructural localization of histamine in human basophils and mast cells; changes associated with anaphylactic degranulation and recovery demonstrated with a diamine oxidase-gold probe.

abstract：:This is a description of the Study of Asthma, Genes and the Environment (SAGE), a novel birth cohort created from provincial healthcare administrative records. It is a general population-based cohort, composed of children at high and low risk for asthma, living in urban and rural environments in Manitoba, Canada. The ...

journal_title：Allergy

authors： Kozyrskyj AL,HayGlass KT,Sandford AJ,Paré PD,Chan-Yeung M,Becker AB

更新日期：2009-08-01 00:00:00

abstract：:Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL-33 receptor. IL-33 receptor is a heterodimer of IL-1 receptor-like 1 (IL-1RL1; also called ST2, T1, Der4, an...

journal_title：Allergy

authors： Ohno T,Morita H,Arae K,Matsumoto K,Nakae S

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE l...

journal_title：Allergy

authors： Tewfik MA,Bossé Y,Lemire M,Hudson TJ,Vallée-Smejda S,Al-Shemari H,Laprise C,Desrosiers M

更新日期：2009-05-01 00:00:00

abstract：:Airways inflammation involves accumulation of inflammatory cells such as eosinophils, basophils and mast cells, which are derived from progenitors in marrow and blood. The inflamed tissue of the airways, through its structural (epithelium, stroma) and inflammatory cell components, produces an array of cytokines which ...

journal_title：Allergy

authors： Denburg JA

更新日期：1995-01-01 00:00:00

abstract：:Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted pap...

journal_title：Allergy

authors： Ren MQ,Zhou YT,Chen HX,Li TY,Vajandar SK,Osipowicz T,Watt F,Li CW

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible in pediatric populations. Tape strips are an emerging, minimally invasive alternative, but global transcriptomic profiling in early pediatric AD is lacking. We aimed t...

journal_title：Allergy

authors： Pavel AB,Renert-Yuval Y,Wu J,Del Duca E,Diaz A,Lefferdink R,Fang MM,Canter T,Rangel SM,Zhang N,Krueger JG,Paller AS,Guttman-Yassky E

更新日期：2021-01-01 00:00:00

abstract：:Application of strict diagnostic criteria to celiac disease has led to the realization that there is a wide clinical spectrum within this disease. Normally there are immune reactions to dietary proteins, particularly secretory antibodies of IgA class, low titers of serum antibody and specific down-regulation of IgE an...

journal_title：Allergy

authors： Ferguson A

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Dissecting complex diseases in underlying distinct traits and studying these for their genetic basis might enhance the power as well as the specificity, of detection of disease genes. These phenotypes are known as intermediate phenotypes. OBJECTIVE:We were interested in the atopic basis of asthma, and used ...

journal_title：Allergy

authors： Kurz T,Altmueller J,Strauch K,Rüschendorf F,Heinzmann A,Moffatt MF,Cookson WO,Inacio F,Nürnberg P,Stassen HH,Deichmann KA

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Allergic asthma is a chronic airway inflammatory disease involving the complementary actions of innate and adaptive immune responses. Endogenously generated cannabinoids acting via CB2 receptors play important roles in both homeostatic and inflammatory processes. However, the contribution of CB2-acting eicos...

journal_title：Allergy

authors： Ferrini ME,Hong S,Stierle A,Stierle D,Stella N,Roberts K,Jaffar Z

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. OBJECTIVE:To establish the incidence and course of challenge-confirmed HEA in children...

journal_title：Allergy

authors： Xepapadaki P,Fiocchi A,Grabenhenrich L,Roberts G,Grimshaw KE,Fiandor A,Larco JI,Sigurdardottir S,Clausen M,Papadopoulos NG,Dahdah L,Mackie A,Sprikkelman AB,Schoemaker AA,Dubakiene R,Butiene I,Kowalski ML,Zeman K,Gavri

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Two-flow cytometry methods for quantification of degranulated basophil after allergen-specific activation were discussed. The methods are discerned by used membrane receptors--FcepsilonRI or IL-3Ralpha Our goal was to evaluate the diagnostic potential of the methods and to correlate them to allergen-specific...

journal_title：Allergy

authors： Michova A,Abugalia M,Ivanova Ts,Nikolov G,Taskov H,Petrunov B

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water da...

journal_title：Allergy

authors： Savilahti R,Uitti J,Roto P,Laippala P,Husman T

更新日期：2001-02-01 00:00:00

abstract：:Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is wid...

journal_title：Allergy

authors： Ramirez LF,Pereira A,Chiriac AM,Bonnet-Boyer MC,Demoly P

更新日期：2012-03-01 00:00:00

abstract：:Birch and other related trees of the families Betulaceae and Fagaceae (alder, hazel, oak, hornbeam, chestnut, and beech) constitute the birch homologous group. This grouping is primarily based on the extensive IgE cross-reactivity of allergen homologs to the major birch allergen Bet v 1. Birch pollen is the most domin...

journal_title：Allergy

authors： Biedermann T,Winther L,Till SJ,Panzner P,Knulst A,Valovirta E

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. OBJECTIVE:To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with...

journal_title：Allergy

authors： Boralevi F,Hubiche T,Léauté-Labrèze C,Saubusse E,Fayon M,Roul S,Maurice-Tison S,Taïeb A

更新日期：2008-02-01 00:00:00

abstract：:The prevalence and specificity of naturally occurring human IgA anti-IgE autoantibodies (a-E Ab) were studied by ELISA with anti-IgA monoclonal antibodies (mAb) and a purified myeloma IgE as solid-phase protein, i.e., IgE-DES(kappa). Such detected IgA a-E Ab were common among adults, and significantly increased geomet...

journal_title：Allergy

authors： Magnusson CG

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Hippo-Yes-associated protein (YAP) pathway plays an important role in epithelial cell proliferation and development. However, its possible role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unknown. We aim to investigate it on nasal epithelial proliferation and remodeling in CRSwNP. METHODS:T...

journal_title：Allergy

authors： Deng H,Sun Y,Wang W,Li M,Yuan T,Kong W,Huang X,Long Z,Chen Z,Wang D,Yang Q

更新日期：2019-04-01 00:00:00

abstract：:Ispaghula powder, which is used as a component in bulk laxatives, is known to induce allergic reactions when inhaled by occupationally exposed persons. We have tested whether nurses sensitized by inhalation could get allergic symptoms when challenged by eating ispaghula. Of six nurses tested, all developed symptoms fr...

journal_title：Allergy

authors： Machado L,Stålenheim G

更新日期：1984-01-01 00:00:00

abstract：:In order to determine the asthma prevalence in 6-12-year-old schoolchildren in Istanbul, we issued 2350 questionnaires, according to ISAAC criteria, in six randomly selected city primary schools to be completed at home by parents. A total of 2232 of the questionnaires were completed, an overall response rate of 94.9%,...

journal_title：Allergy

authors： Oneş U,Sapan N,Somer A,Dişçi R,Salman N,Güler N,Yalçin I

更新日期：1997-05-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) occurs in up to one-third of the adult US population. Most affected individuals are either unaware of their condition or do not seek medical help, relying on nonprescription acid suppressants and antacids for relief. GERD, a common disorder of infancy, old age, and pregnancy, is ...

journal_title：Allergy

authors： Theodoropoulos DS,Lockey RF,Boyce HW Jr,Bukantz SC

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Despite considerable efforts to develop anti dust mite strategies, surprisingly few studies have evaluated the allergen content in different types of mattresses in everyday use. This study investigated the presence of mite feces (an indicator of mite allergens) in foam and spring mattresses. METHODS:The hom...

journal_title：Allergy

authors： Schei MA,Hessen JO,Lund E

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:CD40 and OX40 Ligand (OX40L) are cell-surface molecules expressed on airway smooth muscle (ASM) that can enhance inflammatory cell activation and survival. The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expres...

journal_title：Allergy

authors： Krimmer DI,Loseli M,Hughes JM,Oliver BG,Moir LM,Hunt NH,Black JL,Burgess JK

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The house dust mite (HDM) Dermatophagoides pteronyssinus is a major allergen source eliciting allergic asthma. The aim of the study was to identify new important HDM allergens associated with allergic asthma. METHODS:A cDNA coding for a new mite allergen, designated Der p 21, was isolated using immunoglobul...

journal_title：Allergy

authors： Weghofer M,Dall'Antonia Y,Grote M,Stöcklinger A,Kneidinger M,Balic N,Krauth MT,Fernández-Caldas E,Thomas WR,van Hage M,Vieths S,Spitzauer S,Horak F,Svergun DI,Konarev PV,Valent P,Thalhamer J,Keller W,Valenta R,Vrtal

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The contribution of B-cell subsets and T-B cell interaction to the pathogenesis of allergic rhinitis (AR) and mechanisms of allergen immunotherapy (AIT) remain poorly understood. This study aimed to outline circulating B-cell signature, the underlying mechanism, and its association with clinical response to ...

journal_title：Allergy

authors： Yao Y,Wang N,Chen CL,Pan L,Wang ZC,Yunis J,Chen ZA,Zhang Y,Hu ST,Xu XY,Zhu RF,Yu D,Liu Z

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Previous US population-based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10-year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. METHODS:Patients who died from anaphyl...

journal_title：Allergy

authors： Simon MR,Mulla ZD

更新日期：2008-08-01 00:00:00

abstract：:Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the develo...

journal_title：Allergy

authors： Breiteneder H,Peng YQ,Agache I,Diamant Z,Eiwegger T,Fokkens WJ,Traidl-Hoffmann C,Nadeau K,O'Hehir RE,O'Mahony L,Pfaar O,Torres MJ,Wang DY,Zhang L,Akdis CA

更新日期：2020-09-07 00:00:00

abstract：:The purpose of this study was to investigate whether uncontrolled asthma was associated with healthcare outcomes among Latin American patients with asthma. We used data from 2168 patients with asthma who participated in the 2011 Latin America Asthma Insights and Management (AIM) survey. Using Global Initiative for Ast...

journal_title：Allergy

authors： Gold LS,Montealegre F,Allen-Ramey FC,Jardim J,Smith N,Sansores R,Sullivan SD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Vernal keratoconjunctivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficacious treatment. The aims of the study were to determine quantities and distribution of Hsp chaperones in the conjunctiva of VKC patients and assess their levels in conjunctival epithelial an...

journal_title：Allergy

authors： Leonardi A,Tarricone E,Corrao S,Alaibac M,Corso AJ,Zavan B,Venier P,Conway de Macario E,Macario AJ,Di Stefano A,Cappello F,Brun P

更新日期：2016-03-01 00:00:00

abstract：:Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...

journal_title：Allergy

authors： Howarth PH,Salagean M,Dokic D

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic. METHODS:Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Ev...

journal_title：Allergy

authors： Matsui EC,Sampson HA,Bahnson HT,Gruchalla RS,Pongracic JA,Teach SJ,Gergen PJ,Bloomberg GR,Chmiel JF,Liu AH,Kattan M,Sorkness CA,Steinbach SF,Story RE,Visness CM,Inner-city Asthma Consortium.

更新日期：2010-11-01 00:00:00