Abstract:
BACKGROUND:Chronic idiopathic urticaria (CIU) impairs quality of life (QoL). Currently, no consensus exists regarding how second-generation H(1)-antihistamines (proven to control CIU symptoms) should be taken long-term: as daily treatment or only when symptoms return (PRN). We sought to determine which regimen improves or better maintains QoL in CIU: desloratadine (DL) daily or PRN. METHODS:Subjects with CIU initially responding to DL 5 mg/day for 4 weeks were randomized for an additional 8 weeks, to DL 5 mg/day (arm 1: 'continuous', n = 46) or to DL only on days when urticarial wheals were present (arm 2: "PRN", n = 60). To ensure blinding, treatment was presented in both arms as a combination of daily treatment (arm 1: DL; arm 2: placebo), plus a "rescue" tablet (arm 1: placebo; arm 2: DL) to be taken only in case of symptoms. The main outcome measure was QoL assessed by the VQ-Dermato, a validated French QoL instrument, and the Dermatology Life Quality Index (DLQI). RESULTS:At 4 and 8 weeks after randomization, subjects taking continuous DL showed statistically significant improvements in VQ-Dermato Global Index score (P = 0.001 and P = 0.016, respectively) and dimension scores for daily living activity, mood state, and social functioning vs subjects taking DL PRN. Improvement in DLQI score at Week 4 was also significantly greater with continuous DL (P = 0.001). CONCLUSION:Continuous daily therapy with DL 5 mg is a better regimen than PRN treatment to maintain or improve QoL in subjects with CIU.
journal_name
Allergyjournal_title
Allergyauthors
Grob JJ,Auquier P,Dreyfus I,Ortonne JPdoi
10.1111/j.1398-9995.2008.01913.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
605-12issue
4eissn
0105-4538issn
1398-9995pii
ALL1913journal_volume
64pub_type
杂志文章,多中心研究,随机对照试验相关文献
ALLERGY文献大全abstract:BACKGROUND:Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pruritic hives. While clinical symptoms are due to the release of histamine by cutaneous mast cells, the underlying pathophysiology is still unknown. However, previous studies indicate that basophils might be of releva...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.13215
更新日期:2017-12-01 00:00:00
abstract::Using monoclonal anti-human IgE antibodies recognizing the D epsilon 1 or D epsilon 2 epitope, we have developed a sandwich radioimmunoassay (RIA) to determine IgE in human cell cultures. With the help of this assay, various methods of measuring an actual de novo IgE synthesis were compared. It was necessary to subtra...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1986.tb00327.x
更新日期:1986-08-01 00:00:00
abstract::Chip pile workers are exposed to high concentrations of airborne mould spores. Few sporadic cases of allergic alveolitis have been reported in Finland. Eight non-smoking workers, six on chip piles and two on bark piles, were examined to study the immunological and clinical response to continuous mould spore exposure. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00380.x
更新日期:1987-10-01 00:00:00
abstract::This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA, and IgE to Candida albicans, C. utilis, Cryptococcus albidus, Rhodotorula rubra, and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblot...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb04088.x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti-microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio....
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14058
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Measurement of exposure to the dust mite allergen Der p 1 is important in asthma research and is potentially useful in managing asthma. As no single measure can capture all characteristics of an exposure, it is important to recognize differences in the available methods of measuring exposure to Der p 1. MET...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00228.x
更新日期:2003-08-01 00:00:00
abstract:UNLABELLED:Aspirin-induced asthma (AIA) is a clinical syndrome characterized by acute airway reaction to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS). The most recent etiological hypothesises is that an overexpression of the enzyme LTC(4) synthase occurs in AIA, with the consequent production of sulf...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1398-9995.2003.00351.x
更新日期:2004-03-01 00:00:00
abstract::The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial pr...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12809
更新日期:2016-03-01 00:00:00
abstract::An egg protein, lysozyme, is a still unlabeled additive currently used in cheese preparation. Furthermore, the WHO-FAO committee considers it innocuous. However, 31% of children and 8% of adults with food allergies are allergic to eggs. This work aimed to determine the percentage of patients sensitized to lysozyme fro...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1997.tb00980.x
更新日期:1997-02-01 00:00:00
abstract::A study was performed in 43 workers exposed to methyltetrahydrophthalic anhydride (MTHPA) used as a hardener in an epoxy resin system. Ten workers sensitized to MTHPA (group SS; presence of serum IgE antibodies against a conjugate of MTHPA and human serum albumin (HSA) detected by RAST) had significantly higher levels...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb02661.x
更新日期:1994-04-01 00:00:00
abstract::Basophil histamine release was studied in leukocyte suspensions from normal individuals and from patients allergic to house dust mite or birch pollen. Mediator release caused by IgE-mediated reactions was examined by stimulating the cells with anti-IgE or specific antigens, and the calcium ionophore A23187 was used fo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1990.tb01099.x
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Efficacy testing of immunotherapy in field studies is often hampered by variation of airborne allergens. Standardized allergen exposure in challenge chamber settings might be an alternative. Therefore, we developed a universal technique to create an atmosphere loaded with allergen particles of adjustable siz...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12947
更新日期:2016-12-01 00:00:00
abstract::Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been considered a paradigmatic type 2 immunity (T2)-driven disease. Interleukin (IL)-4 and IL-13 are both pivotal cytokines involved in the generation of allergic diseases. Currently, besides dupilumab, which blocks the binding of bo...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13954
更新日期:2020-01-01 00:00:00
abstract::Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including geneti...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12126
更新日期:2013-04-01 00:00:00
abstract::It was the aim of the study to compare the efficacy and side effects of oral antihistamine and nasal glucocorticoid therapy in seasonal allergic, rhinitis. In a double blind, double-dummy, group-comparative study, 61 adult grass pollen allergic patients were either treated with dexchlorpheniramine maleate sustained re...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1983.tb02361.x
更新日期:1983-10-01 00:00:00
abstract::In summary, beta 2-adrenergic agonists and corticosteroids can interact to produce beneficial effects on airway function. The regular use of short-acting, beta 2-adrenergic agonists as relief therapy is safe and effective; however, some degree of caution may be required with the use of very high doses. Long-acting bet...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1998.tb04887.x
更新日期:1998-01-01 00:00:00
abstract::Respiratory allergies and subclinical sensitization to aeroallergens were investigated in 129 rural and in 222 urban probands. The incidence of respiratory allergies was not significantly higher in the urban residents. Sensitization to aeroallergens was investigated with Phadezym RAST (house dust mite, Cladosporium, o...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1989.tb04202.x
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Immunoglobulin (Ig) A represents a first-line defence mechanism in the airways, but little is known regarding its implication in upper airway disorders. This study aimed to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic upper airway disea...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12274
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The atopy patch test (APT) is an in vivo model to study the induction of eczema by inhalant allergens. This study was designed to compare two commonly used APT methods. METHODS:In the first method, the allergen is dissolved in aqueous solution, which is applied on tape-stripped skin. In the second method, t...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2003.00379.x
更新日期:2004-04-01 00:00:00
abstract::Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods and management of acute allergic reactions with antihistamines an...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14116
更新日期:2020-06-01 00:00:00
abstract::The possible dependence of the dual cutaneous reaction (DCR) on activation of the complement and coagulation systems was further elucidated. Heterologous whole anti-human IgE was injected intradermally (i.d.) on the volar aspect of the forearms of 17 drug-free healthy volunteers and venous samples for the selected lab...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1985.tb00883.x
更新日期:1985-11-01 00:00:00
abstract::The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1990.tb00466.x
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS:MEDLINE was searched for articles re...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2004.00563.x
更新日期:2004-08-01 00:00:00
abstract::Indications for in vitro fertilization (IVF) have been cautiously extended over the years. IVF is usually considered to be a technically complex method with only minimal side-effects. We report the case of a woman who developed an anaphylactic reaction during IVF immediately after the embryo transfer. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1994.tb02288.x
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. METHODS:We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018...
journal_title:Allergy
pub_type: 杂志文章,meta分析
doi:10.1111/all.13767
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The capacity of inflammatory cells to adhere involves an array of adhesion molecules, and is critical to the inflammatory responses seen in childhood asthma. We aimed to determine the changes of intercellular adhesion molecule-1 (ICAM-1) and L-selectin expressed on peripheral blood (PB) T lymphocytes and nat...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.t01-1-23697.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Immunoglobulin E (IgE)-mediated allergy belongs to common chronic disorders resulting from an interaction between both genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31.1, a region that is linked to asthma and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00271.x
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Spanish population is rather homogeneous in its genetic and sociocultural characteristics, but allergen sensitization shows wide geographical variations. We aimed at assessing whether sensitization to different allergens in the diverse geographical areas induced different clinical and quality-of-life charact...
journal_title:Allergy
pub_type: 杂志文章,多中心研究
doi:10.1111/all.13141
更新日期:2017-09-01 00:00:00
abstract::A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot t...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1398-9995.1981.tb01861.x
更新日期:1981-10-01 00:00:00
abstract::A variety of methods have been used to attempt to decrease the allergenicity of food products, with highly variable success. Limited knowledge of allergen and epitope structures and the factors governing their stability may explain this, and the ensuing need for an empirical approach. A combined effort from a processi...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2001.00917.x
更新日期:2001-01-01 00:00:00