Comparison of nasal immunohistology in patients with seasonal rhinoconjunctivitis treated with topical steroids or specific allergen immunotherapy.

abstract：BACKGROUND:IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the comp...

journal_title：Allergy

authors： Jensen RK,Jabs F,Miehe M,Mølgaard B,Pfützner W,Möbs C,Spillner E,Andersen GR

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Hippo-Yes-associated protein (YAP) pathway plays an important role in epithelial cell proliferation and development. However, its possible role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unknown. We aim to investigate it on nasal epithelial proliferation and remodeling in CRSwNP. METHODS:T...

journal_title：Allergy

authors： Deng H,Sun Y,Wang W,Li M,Yuan T,Kong W,Huang X,Long Z,Chen Z,Wang D,Yang Q

更新日期：2019-04-01 00:00:00

abstract：:The recent advances in the knowledge of the basic mechanisms underlying asthmatic inflammation have significantly contributed to the delineation of new therapeutic perspectives for asthma. There are currently three main approaches to the development of novel antiasthma treatments: 1) improvement in existing classes of...

journal_title：Allergy

authors： Pelaia G,Vatrella A,Calabrese C,Mazzarella G,Marsico SA

更新日期：2000-01-01 00:00:00

abstract：:In a double-blind controlled trial 41 hospitalized adults with severe, perennial asthma of unknown aetiology were allocated to either an antigen-free elemental diet (Vivasorb) or control diet, i.e. blended ordinary hospital food, for 2 weeks. At the time of entry into the trial all patients were in an active but stabl...

journal_title：Allergy

authors： Høj L,Osterballe O,Bundgaard A,Weeke B,Weiss M

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Local application of allergen extracts in specific immunotherapy is accompanied by increased compliance and significantly reduced side effects. However, efficacy of local immunotherapy in children has yet not been sufficiently demonstrated. This study was performed to determine clinical efficacy of high dose...

journal_title：Allergy

authors： Bufe A,Ziegler-Kirbach E,Stoeckmann E,Heidemann P,Gehlhar K,Holland-Letz T,Braun W

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...

journal_title：Allergy

authors： Platzer MH,Grattan CE,Poulsen LK,Skov PS

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:There has been no study for evaluating the associations of human leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate (TDI)-induced asthma in an Asian population. OBJECTIVE:The aim of this study was to investigate a susceptible or protective marker of HLA class I and II alleles in TDI-in...

journal_title：Allergy

authors： Kim SH,Oh HB,Lee KW,Shin ES,Kim CW,Hong CS,Nahm DH,Park HS

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:The association between cigarette smoke exposure and allergic airway disease is a matter for debate. We sought to investigate in an in vitro system whether active smoking reduces the integrity and barrier function of the respiratory epithelium and thus facilitates allergen penetration. METHODS:We cultured t...

journal_title：Allergy

authors： Gangl K,Reininger R,Bernhard D,Campana R,Pree I,Reisinger J,Kneidinger M,Kundi M,Dolznig H,Thurnher D,Valent P,Chen KW,Vrtala S,Spitzauer S,Valenta R,Niederberger V

更新日期：2009-03-01 00:00:00

abstract：:Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the develo...

journal_title：Allergy

authors： Breiteneder H,Peng YQ,Agache I,Diamant Z,Eiwegger T,Fokkens WJ,Traidl-Hoffmann C,Nadeau K,O'Hehir RE,O'Mahony L,Pfaar O,Torres MJ,Wang DY,Zhang L,Akdis CA

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:The reported association of allergy and sinusitis varies greatly between study, and the exact role of allergy in predisposing to sinusitis is not clear. We attempted to determine whether patients with perennial allergic rhinitis are at greater risk of developing sinusitis with respect to a control group, and...

journal_title：Allergy

authors： Berrettini S,Carabelli A,Sellari-Franceschini S,Bruschini L,Abruzzese A,Quartieri F,Sconosciuto F

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q(2)oL) and to provide reference assessments of QoL. METHODS:The...

journal_title：Allergy

authors： Młynek A,Magerl M,Hanna M,Lhachimi S,Baiardini I,Canonica GW,Brzoza Z,Kasperska-Zajac A,Rogala B,Zalewska-Janowska A,Zuberbier T,Maurer M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. METHODS:FLG mutations R501X, 2282del4 and R2447X were genotyped in the Prevention and Incidence of Asthma and Mite Allergy birth cohort (n = 934) to evalu...

journal_title：Allergy

authors： Schuttelaar ML,Kerkhof M,Jonkman MF,Koppelman GH,Brunekreef B,de Jongste JC,Wijga A,McLean WH,Postma DS

更新日期：2009-12-01 00:00:00

abstract：:The background of this study is the finding of several studies that the frequency of respiratory allergies was significantly higher in the former West Germany than the former East Germany. The present study investigated the levels of allergens of house-dust mite (Der p 1 and Der f 1), cat (Fel d 1), and cockroach (Bla...

journal_title：Allergy

authors： Fahlbusch B,Heinrich J,Gross I,Jäger L,Richter K,Wichmann HE

更新日期：1999-11-01 00:00:00

abstract：:Bee venom obtained by electrical stimulation has been analysed by crossed immunoelectrophoresis against high-titer rabbit antibodies. The antigenic analysis of bee venom revealed that the extract contained 17 antigens, which were detected in the crossed immunoelectrophoresis pattern after staining with Coomassie Brill...

journal_title：Allergy

authors： Einarsson R,Annerhed A,Karlsson R,Olsson B,Renck B

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:Bronchial asthma is a chronic disease characterized by inflammation, obstruction, and hyperresponsiveness of the airways. There is currently no curative therapy for asthma. Type 2 helper T cell response plays a critical role in the pathogenesis of the disease. Protein S is a glycoprotein endowed with anticoa...

journal_title：Allergy

authors： Asayama K,Kobayashi T,D'Alessandro-Gabazza CN,Toda M,Yasuma T,Fujimoto H,Okano T,Saiki H,Takeshita A,Fujiwara K,Fridman D'Alessandro V,Nishihama K,Totoki T,Inoue R,Takei Y,Gabazza EC

更新日期：2020-09-01 00:00:00

abstract：:Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase ...

journal_title：Allergy

authors： Agache I,Beltran J,Akdis C,Akdis M,Canelo-Aybar C,Canonica GW,Casale T,Chivato T,Corren J,Del Giacco S,Eiwegger T,Firinu D,Gern JE,Hamelmann E,Hanania N,Mäkelä M,Hernández-Martín I,Nair P,O'Mahony L,Papadopoulos NG

更新日期：2020-05-01 00:00:00

abstract：:Olea europaea (olive) pollen extract was prepared by aqueous extraction and characterized by biochemical and immunochemical methods. Two components, displaying respective mol. wt. of 17,000 and 19,000, were the most reactive allergens, being the doublet (designated Ole e I) recognized by most sera tested. The 19,000 m...

journal_title：Allergy

authors： De Cesare F,Pini C,Di Felice G,Caiaffa MF,Macchia L,Tursi A,Tinghino R,Palumbo S,Sallusto F,Federico R

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Chronic respiratory diseases (CRD) are greatly underestimated. The aim of this study was to assess the burden associated with reported CRD and chronic obstructive pulmonary disease, as defined on the basis of various standardized criteria, by estimating their point prevalence in a sample of individuals atten...

journal_title：Allergy

authors： Martins P,Rosado-Pinto J,do Céu Teixeira M,Neuparth N,Silva O,Tavares H,Spencer JL,Mascarenhas D,Papoila AL,Khaltaev N,Annesi-Maesano I

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Levels of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs in breast milk are associated with the development of allergic diseases up to school age. However, it is unknown whether this relationship persists when the child becomes older. We therefore studied the association between levels of n-3 PUFAs an...

journal_title：Allergy

authors： van Elten TM,van Rossem L,Wijga AH,Brunekreef B,de Jongste JC,Koppelman GH,Smit HA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY:To investigate the immunol...

journal_title：Allergy

authors： Hanf G,Brachmann I,Kleine-Tebbe J,Seybold J,Kunkel G,Suttorp N,Noga O

更新日期：2006-09-01 00:00:00

abstract：:It was the aim of this investigation to study the efficacy of a corticosteroid given as a depot injection in seasonal allergic rhinitis, the efficacy profile with regard to specific symptoms, and whether the injection is best given early in the season or later at the peak of the pollen count. An injection of 80 mg met...

journal_title：Allergy

authors： Borum P,Grønborg H,Mygind N

更新日期：1987-01-01 00:00:00

abstract：:The hygiene hypothesis states that a reduced exposure to allergens in early life is solely implicated in the growing propensity for allergy sensitization. Important elements of the hypothesis include helminth infection, exposure to endotoxins, exposure to pets and growing up on a farm. However, the hygiene hypothesis ...

journal_title：Allergy

authors： Platts-Mills TA,Erwin E,Heymann P,Woodfolk J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Few time-series studies, and none lasting longer than 4 years, have investigated the etiology of treated seasonal allergic rhinoconjunctivitis (SAR) on the basis of anti-allergic medication prescriptions. The aim of this article was to study the short-term relationship between pollen exposure and drug-treate...

journal_title：Allergy

authors： Caillaud DM,Martin S,Ségala C,Vidal P,Lecadet J,Pellier S,Rouzaire P,Tridon A,Evrard B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Artemisia annua is an important autumnal pollen allergen for seasonal allergic rhinitis (SAR) in northern China. To date, no study has investigated allergen immunotherapy with A annua. We aimed to investigate the efficacy and mechanisms underlying A annua-sublingual immunotherapy (SLIT). METHODS:This was a ...

journal_title：Allergy

authors： Lou H,Huang Y,Ouyang Y,Zhang Y,Xi L,Chu X,Wang Y,Wang C,Zhang L

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Improving quality of life is considered to be a major endpoint and motivation for clinical intervention in patients with perennial allergic rhinitis (PAR). In addition to classical symptoms of congestion, pruritus, and rhinorrhea, patients will often complain of not being able to sleep well at night and of f...

journal_title：Allergy

authors： Hughes K,Glass C,Ripchinski M,Gurevich F,Weaver TE,Lehman E,Fisher LH,Craig TJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:We report on a 37-year-old man without history of previous allergic disease who developed an aseptic intolerance reaction to a chromium-cobalt alloy, with local discomfort, loosening, and absence of fracture healing. Both in vivo and in vitro allergoimmunologic diagnostic tests were performed. METHODS:Patch...

journal_title：Allergy

authors： Thomas P,Summer B,Sander CA,Przybilla B,Thomas M,Naumann T

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study. METHODS:The concentration of profili...

journal_title：Allergy

authors： Ruiz-Hornillos J,López-Matas MA,Berges Jimeno P,Henríquez A,Blanco S,Seoane-Rodríguez M,Mahíllo I,Carnés J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Because little is known about the effects of asthma and asthma therapy on lipid and protein metabolism, we have investigated the characteristics of diet and plasma/serum levels of fat and protein in a group of asthma patients with various degrees of severity. METHODS:A case-control study was carried out on ...

journal_title：Allergy

authors： Picado C,Deulofeu R,Lleonart R,Agustí M,Casals E,Quintó L,Mullol J

更新日期：1999-06-01 00:00:00

abstract：:A 60-year-old man developed an anaphylactic reaction immediately after administration of intramuscular sodium cefuroxime. By means of oral controlled challenge, the reaction was reproduced with a smaller dose of cefuroxime axetil. Cross-reactivity with other betalactam antibiotics was ruled out by in vivo tests. This ...

journal_title：Allergy

authors： Marcos Bravo C,Luna Ortiz I,González Vázquez R

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:To date, there has been no reliable in vitro test to either diagnose or differentiate nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). The aim of the present study was to develop and validate an artificial neural network (ANN) for the prediction of N-ERD in patients with a...

journal_title：Allergy

authors： Tyrak KE,Pajdzik K,Konduracka E,Ćmiel A,Jakieła B,Celejewska-Wójcik N,Trąd G,Kot A,Urbańska A,Zabiegło E,Kacorzyk R,Kupryś-Lipińska I,Oleś K,Kuna P,Sanak M,Mastalerz L

更新日期：2020-07-01 00:00:00