Allergen-induced release of sulphidopeptide leukotrienes (SRS-A) and LTB4 in allergic rhinitis.

abstract：BACKGROUND:Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5Ralpha) isoform, or a secreted (SOL IL-5Ralpha) isoform, on both protein and transcript level in vitro and in vivo. METHODS:A real-time PCR, FACS and ELISA were establ...

journal_title：Allergy

authors： Gevaert P,Hellman C,Lundblad L,Lundahl J,Holtappels G,van Cauwenberge P,Tavernier J,Bachert C

更新日期：2009-05-01 00:00:00

abstract：:The scarce data published on mite sensitization and mite-allergen levels in Norway indicate that the mites may not be of the same importance in allergic disease in Norway as in countries such as the UK and the rest of Europe. The problem also involves the low allergen levels and small amounts of dust collected for all...

journal_title：Allergy

authors： Gaarder PI

更新日期：1998-01-01 00:00:00

abstract：:It was the aim of this investigation to study the efficacy of a corticosteroid given as a depot injection in seasonal allergic rhinitis, the efficacy profile with regard to specific symptoms, and whether the injection is best given early in the season or later at the peak of the pollen count. An injection of 80 mg met...

journal_title：Allergy

authors： Borum P,Grønborg H,Mygind N

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control. OBJECTIVES:To study the degree of CRS c...

journal_title：Allergy

authors： van der Veen J,Seys SF,Timmermans M,Levie P,Jorissen M,Fokkens WJ,Hellings PW

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Skin prick tests (SPTs) play an important role in the diagnosis of baker's asthma and in the investigation of sensitization frequencies in field studies. It was the aim of our study to compare different SPT solutions for wheat and rye flour sensitization and to assess the validity of test results. METHODS:S...

journal_title：Allergy

authors： Sander I,Merget R,Degens PO,Goldscheid N,Brüning T,Raulf-Heimsoth M

更新日期：2004-01-01 00:00:00

abstract：:Phospholipase A2 (E.C. 3.1.1.4.) is a major allergen of honey bee venom. It exists in a glycosylated and an unglycosylated variant. Both forms and the glycopeptide isolated after exhaustive proteolytic digestion were tested in RAST and RAST inhibition studies. IgE from 11 of 14 bee venom allergy sera exhibited signifi...

journal_title：Allergy

authors： Weber A,Schröder H,Thalberg K,März L

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Allergy has at least two components - a genetic predisposition referred to as atopy and the progress from an atopic state to clinically apparent disease. Peripheral blood monocytes are circulating myeloid precursors of antigen-presenting cells. The expression of cell surface proteins on monocytes may therefo...

journal_title：Allergy

authors： von Bubnoff D,Scheler M,Hinz T,Matz H,Koch S,Bieber T

更新日期：2004-09-01 00:00:00

abstract：:The mite fauna in hay dust of 16 farms located on the island of Gotland was analysed to establish whether there is a clear relationship between environmental exposure to storage mites and development of allergic symptoms. Eight of these farms belonged to farmers with respiratory symptoms related to barn dust (RS) and ...

journal_title：Allergy

authors： van Hage-Hamsten M,Johansson E,Wirén A,Johansson SG

更新日期：1991-02-01 00:00:00

abstract：:Occupational respiratory allergy to green coffee beans in coffee roastery workers is well established. I now report on a 50-year-old female atopic patient sensitized to the coffee plant used for indoor decoration. The symptoms were rhinitis and conjunctivitis on exposure to the plant. Investigation showed a positive s...

journal_title：Allergy

authors： Axelsson IG

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to comp...

journal_title：Allergy

authors： Chan-Yeung M,Anthonisen NR,Becklake MR,Bowie D,Sonia Buist A,Dimich-Ward H,Ernst P,Sears MR,Siersted HC,Sweet L,Van Til L,Manfreda J

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Alkaline serine proteases from six prevalent airborne Penicillium and Aspergillus species have been identified as a group of major allergens (group 13). After entering human airways, the allergens are in initial contacts with respiratory epithelial cells. The purpose of this study is to investigate interacti...

journal_title：Allergy

authors： Tai HY,Tam MF,Chou H,Peng HJ,Su SN,Perng DW,Shen HD

更新日期：2006-03-01 00:00:00

abstract：:Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...

journal_title：Allergy

authors： Shoda T,Futamura K,Kobayashi F,Saito H,Matsumoto K,Matsuda A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Effective methods of reducing dog allergen are required to help alleviate symptoms in asthmatic patients sensitized to dog who refuse to part with their pet. The aim of this study was to investigate the use of the high efficiency particulate air (HEPA) filter air cleaner to reduce airborne Can f 1 in homes w...

journal_title：Allergy

authors： Green R,Simpson A,Custovic A,Faragher B,Chapman M,Woodcock A

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The pollen-food syndrome (PFS) is an association of food allergies to fruits, nuts, and vegetables in patients with pollen allergy. Mal d 1, the major apple allergen, is one of the most commonly associated food allergens for birch pollen-allergic patients suffering from PFS. Although the reactions are due to...

journal_title：Allergy

authors： Klinglmayr E,Hauser M,Zimmermann F,Dissertori O,Lackner P,Wopfner N,Ferreira F,Wallner M

更新日期：2009-04-01 00:00:00

abstract：:The clinical scoring systems of atopic dermatitis were analysed and compared. Some biological parameters that can correlate with the clinical score were also reviewed. After the definition of the disease based on validated clinical criteria, the second necessity was the availability of reliable severity scores to allo...

journal_title：Allergy

authors： Gelmetti C,Colonna C

更新日期：2004-08-01 00:00:00

abstract：:The prick test is one of the most common medical methods for diagnosing allergies, and it has been carried out in a similar and laborious manner over many decades. In an attempt to standardize the reading of the test, many researchers have tried to automate the process of measuring the allergic reactions found by deve...

journal_title：Allergy

authors： Justo X,Díaz I,Gil JJ,Gastaminza G

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS:Utilizing flow cytometry to identify circulating, collagen type 1+ cells,...

journal_title：Allergy

authors： Wright AK,Newby C,Hartley RA,Mistry V,Gupta S,Berair R,Roach KM,Saunders R,Thornton T,Shelley M,Edwards K,Barker B,Brightling CE

更新日期：2017-04-01 00:00:00

abstract：:IgG-binding to the surface of Langerhans cells (LC) is a feature of primary Sjögren's syndrome and might be associated with qualitative and quantitative defects in LC. Fifteen patients with primary Sjögren's syndrome and 15 healthy controls had a punch biopsy performed from clinically unaffected skin. LC were enumerat...

journal_title：Allergy

authors： Oxholm P,Oxholm A,Manthorpe R

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Nasopharynx-associated lymphoid tissue (NALT) serves as an important inductive site for mucosal immunity in the upper respiratory tract. Despite its importance in the mucosal immune system, little is known regarding the role of NALT in airway allergic immune responses. We aimed to elucidate the role of NALT ...

journal_title：Allergy

authors： Kim DY,Fukuyama S,Nagatake T,Takamura K,Kong IG,Yokota Y,Lee CH,Kiyono H

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. METHODS:Baseline pati...

journal_title：Allergy

authors： Sullivan SD,Rasouliyan L,Russo PA,Kamath T,Chipps BE,TENOR Study Group.

更新日期：2007-02-01 00:00:00

abstract：:Nonallergic non-infectious perennial rhinitis (NANIPER) is a heterogeneous disorder comprising several pathophysiological entities. The etiology of some of these disorders (e.g. drug-induced rhinitis, nonallergic rhinitis with eosinophilia syndrome [NARES], occupational rhinitis, hormonal rhinitis, emotion-induced rhi...

journal_title：Allergy

authors： Garay R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...

journal_title：Allergy

authors： Sullivan SD,Wenzel SE,Bresnahan BW,Zheng B,Lee JH,Pritchard M,Kamath TV,Weiss ST,TENOR Study Group.

更新日期：2007-06-01 00:00:00

abstract：:Standardized bronchial allergen provocation with the same individual allergen dose was performed 3-9 times in 20 symptomless adult asthmatic patients at intervals of 1 week or more during 1/2-22 months in order to study variations in bronchial response. The immediate type reaction was recorded by monitoring FEV1, FVC,...

journal_title：Allergy

authors： Loẅhagen O,Lindholm NB

更新日期：1980-06-01 00:00:00

abstract：:Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, ...

journal_title：Allergy

authors： Stefanovic N,Flohr C,Irvine AD

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma. In mice, this region harbors a locus control region for nearby TH 2 cytokines, which is characterized by four Rad50 DNase I hypersensitive sites (RHS4...

journal_title：Allergy

authors： Schieck M,Sharma V,Michel S,Toncheva AA,Worth L,Potaczek DP,Genuneit J,Kretschmer A,Depner M,Dalphin JC,Riedler J,Frei R,Pekkanen J,Tost J,Kabesch M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Local application of allergen extracts in specific immunotherapy is accompanied by increased compliance and significantly reduced side effects. However, efficacy of local immunotherapy in children has yet not been sufficiently demonstrated. This study was performed to determine clinical efficacy of high dose...

journal_title：Allergy

authors： Bufe A,Ziegler-Kirbach E,Stoeckmann E,Heidemann P,Gehlhar K,Holland-Letz T,Braun W

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Levels of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs in breast milk are associated with the development of allergic diseases up to school age. However, it is unknown whether this relationship persists when the child becomes older. We therefore studied the association between levels of n-3 PUFAs an...

journal_title：Allergy

authors： van Elten TM,van Rossem L,Wijga AH,Brunekreef B,de Jongste JC,Koppelman GH,Smit HA

更新日期：2015-11-01 00:00:00

abstract：:The site of antagonistic action on allergen-induced early skin reactions by the beta 2-agonist terbutaline was studied by light microscopy in 10 atopic subjects. Pretreatment with 1 microgram terbutaline intradermally 5 min prior to challenge with horse dander allergen produced an approximate inhibition of 85 and 55% ...

journal_title：Allergy

authors： Grönneberg R,Lagerholm B

更新日期：1986-01-01 00:00:00

abstract：:Application of strict diagnostic criteria to celiac disease has led to the realization that there is a wide clinical spectrum within this disease. Normally there are immune reactions to dietary proteins, particularly secretory antibodies of IgA class, low titers of serum antibody and specific down-regulation of IgE an...

journal_title：Allergy

authors： Ferguson A

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...

journal_title：Allergy

authors： Price D,Wirén A,Kuna P

更新日期：2007-10-01 00:00:00