Cytoskeletal association of muscle-specific mRNAs in differentiating L6 rat myoblasts.

abstract：:Previous studies have indicated that space flight affects the activation of lymphocytes from humans, monkeys, and rodents. In rats, where lymphocytes from blood, spleen, and lymph nodes have been tested, the accumulated data suggest that the effects of flight on various cells are lymphoid organ-specific. Thus, cells m...

journal_title：Experimental cell research

authors： Grove DS,Pishak SA,Mastro AM

更新日期：1995-07-01 00:00:00

abstract：:Terminally differentiated skeletal muscle myotubes are arrested in G0 phase of the cell cycle and are unable to be released from this arrest by stimulation with mitogens including serum and growth factors. To inspect a possibility of reversing the quiescence at the G0 phase, we have exploited the mouse skeletal muscle...

journal_title：Experimental cell research

authors： Ohkubo Y,Kishimoto T,Nakata T,Yasuda H,Endo T

更新日期：1994-09-01 00:00:00

abstract：:The phenotypic transition of smooth muscle cells (SMC) from a contractile to a synthetic state appears to be an early event in the pathogenesis of atherosclerosis. We examined the effects of extracellular matrix components on the phenotypic modulation of rabbit arterial SMC in primary culture by flow cytometry. The re...

journal_title：Experimental cell research

authors： Yamamoto M,Yamamoto K,Noumura T

更新日期：1993-01-01 00:00:00

abstract：:The macrophages have different subtypes with different functions in immune response and disease. It has been generally accepted that M1 macrophages are responsible for stimulation of immune system and inflammation while M2 macrophages play a role in tissue repair. Irrespective of the type, macrophage functions depend ...

journal_title：Experimental cell research

authors： Liu Y,Minze LJ,Mumma L,Li XC,Ghobrial RM,Kloc M

更新日期：2016-02-15 00:00:00

abstract：:The altered patterns of expression of gangliosides during density-dependent growth inhibition, oncogenic transformation, and embryogenesis suggest that gangliosides, sialylated membrane glycolipids, may affect cellular proliferation and differentiation. Gangliosides of the "b" pathway of ganglioside synthesis, includi...

journal_title：Experimental cell research

authors： Paller AS,Arnsmeier SL,Fisher GJ,Yu QC

更新日期：1995-03-01 00:00:00

abstract：:We have reported that PAP-1, a product of a causative gene for autosomal retinitis pigmentosa, plays a role in splicing. In this study, CIR, a protein originally identified as a CBF1-interacting protein and reported to act as a transcriptional corepressor, was identified as a PAP-1 binding protein and its function as ...

journal_title：Experimental cell research

authors： Maita H,Kitaura H,Ariga H,Iguchi-Ariga SM

更新日期：2005-02-15 00:00:00

abstract：:Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complement...

journal_title：Experimental cell research

authors： Ning Y,Shay JW,Lovell M,Taylor L,Ledbetter DH,Pereira-Smith OM

更新日期：1991-01-01 00:00:00

abstract：:Human and rat neuroblastoma cells extend neurites over plasma fibronectin (pFN)-coated substrata. For resolution of which fibronectin binding activities (the cell-binding domain (CBD), the heparan sulfate-binding domains, or a combination of the two) are responsible for neurite outgrowth, CBD was prepared free of hepa...

journal_title：Experimental cell research

authors： Tobey SL,McClelland KJ,Culp LA

更新日期：1985-06-01 00:00:00

abstract：:Skeletal muscle differentiation is strongly inhibited by transforming growth factor type beta (TGF-beta), although muscle formation as well as regeneration normally occurs in an environment rich in this growth factor. In this study, we evaluated the role of intracellular regulatory Smads proteins as well as TGF-beta-r...

journal_title：Experimental cell research

authors： Droguett R,Cabello-Verrugio C,Santander C,Brandan E

更新日期：2010-09-10 00:00:00

abstract：:1,25-dihydroxyvitamin D(3) (VD(3)) induces differentiation in a number of leukemia cell lines and under various conditions is able to either stimulate or inhibit nuclear factor kappa B (NF-kappaB) activity. Here we report a time-dependent biphasic regulation of NF-kappaB in VD(3)-treated HL-60 leukemia cells. After VD...

journal_title：Experimental cell research

authors： Tse AK,Wan CK,Shen XL,Zhu GY,Cheung HY,Yang M,Fong WF

更新日期：2007-05-01 00:00:00

abstract：:Sepsis is a major cause of mortality in seriously ill patients characterized by a series of severe systemic inflammatory responses due to an infection. Thus, there is a critically need to search more accurate biomarkers and targets for diagnosis and treatment of sepsis. Our study showed that miR-212-3p was up-regulate...

journal_title：Experimental cell research

authors： Chen W,Ma X,Zhang P,Li Q,Liang X,Liu J

更新日期：2017-01-15 00:00:00

abstract：:New methods have been developed for the purification and characterization of the cell wall degrading enzyme, lysin, which is released into the medium during the mating reaction of the biflagellated alga Chlamydomonas reinhardtii. A quantitative spectrophotometric assay that detects the number of cells losing walls was...

journal_title：Experimental cell research

authors： Buchanan MJ,Snell WJ

更新日期：1988-11-01 00:00:00

abstract：:We have tested whether life-long caloric restriction (CR) slows or delays the age-related loss of cellular replicative potential that occurs during normal aging in ad libitum (AL) fed mice. Both mean and maximum life spans of the restricted animals (60% of AL intake) were significantly extended 30-40% by CR treatment....

journal_title：Experimental cell research

authors： Pendergrass WR,Li Y,Jiang D,Fei RG,Wolf NS

更新日期：1995-04-01 00:00:00

abstract：:Translation is mediated partly by regulation of free eukaryotic initiation factor 4E (eIF4E) levels through PI3K-Akt-mTOR signaling. Cancer cells treated with the plant-derived perillyl alcohol (POH) or the mechanistic target of rapamycin (mTOR) inhibitor rapamycin dephosphorylate eIF4E-binding protein (4E-BP1) and at...

journal_title：Experimental cell research

authors： Sundin T,Peffley D,Hentosh P

更新日期：2013-08-01 00:00:00

abstract：:It is known that DNA fragmentation during apoptosis is controlled by a number of factors, a crucial step being the caspase-operated cleavage of ICAD, the DNase inhibitor. We have previously demonstrated that hydrogen peroxide-treated lymphocytes undergo apoptosis without formation of a DNA ladder; however, the use of ...

journal_title：Experimental cell research

authors： Marini M,Frabetti F,Canaider S,Dini L,Falcieri E,Poirier GG

更新日期：2001-06-10 00:00:00

abstract：:The extraocular muscles (EOM) are spared from pathology in aging and many forms of muscular dystrophy. Despite many studies, this sparing remains an enigma. The EOM have a distinct embryonic lineage compared to somite-derived muscles, and we have shown that they continuously remodel throughout life, maintaining a popu...

journal_title：Experimental cell research

authors： Kallestad KM,Hebert SL,McDonald AA,Daniel ML,Cu SR,McLoon LK

更新日期：2011-04-01 00:00:00

abstract：:We have earlier shown that mouse pancreatic acinar cells produce hydrogen sulfide (H(2)S), which plays a key role in the pathogenesis of acute pancreatitis (AP). H(2)S-dependent induction of inflammation is mediated by the activation of transcription factor NF-kappaB. We now provide evidence that activation of Src fam...

journal_title：Experimental cell research

authors： Tamizhselvi R,Koh YH,Sun J,Zhang H,Bhatia M

更新日期：2010-05-15 00:00:00

abstract：:It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs). The internalized receptors are then sorted to lysosomes or recycled to the cell surface. More recently, data have been published to indicate other intracellular destinations for the inter...

journal_title：Experimental cell research

authors： Carpenter G,Liao HJ

更新日期：2009-05-15 00:00:00

abstract：:The recruitment of osteoblast progenitors involves their migration and attachment to the sites of bone formation through interactions with matrix proteins. In a time-limited cell attachment assay, coated laminin-1 inhibits the adhesion of most rat calvaria cells but attaches specifically to osteoprogenitors, as quanti...

journal_title：Experimental cell research

authors： Roche P,Rousselle P,Lissitzky JC,Delmas PD,Malaval L

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:Our purpose was to investigate the role of the nitric oxide (NO) signaling pathway in the regulation of ciliary beat frequency (CBF) in mouse nasal and tracheal epithelial cells. METHODS:We studied the effects of the NO donor l-arginine (L-Arg) and specific inhibitors of the NO signaling pathway on CBF of b...

journal_title：Experimental cell research

authors： Jiao J,Wang H,Lou W,Jin S,Fan E,Li Y,Han D,Zhang L

更新日期：2011-10-15 00:00:00

abstract：:The expression of human cellular fibronectin (HFN) was analyzed in relation to the differentiation process of the human enterocyte-like cell line Caco-2. A single approximately 290-kDa form of HFN, corresponding to a 10.0-kb mRNA species, was observed in Caco-2 cells. The expression levels of both protein and mRNA wer...

journal_title：Experimental cell research

authors： Vachon PH,Simoneau A,Herring-Gillam FE,Beaulieu JF

更新日期：1995-01-01 00:00:00

abstract：:Barrier-to-autointegration factor (BAF) is an essential chromatin protein conserved in metazoans. BAF has roles in nuclear assembly, chromatin organization, gene expression, and gonad development and is exploited by retroviruses. BAF forms stable dimers that bind nonspecifically to dsDNA and specifically to LEM-domain...

journal_title：Experimental cell research

authors： Tifft KE,Segura-Totten M,Lee KK,Wilson KL

更新日期：2006-02-15 00:00:00

abstract：:The giant protein hFat1, a member of the cadherin superfamily, has been proposed to play roles in cerebral development, glomerular slit formation, and also to act as a tumor suppressor, but its mechanisms of action have not been elucidated. To examine functions of the transmembrane and cytoplasmic domains, they were e...

journal_title：Experimental cell research

authors： Magg T,Schreiner D,Solis GP,Bade EG,Hofer HW

更新日期：2005-07-01 00:00:00

abstract：:Serelaxin, a recombinant form of human relaxin-2, is currently regarded as a novel drug for treatment of acute heart failure. However, whether therapeutic effects of serelaxin are achieved by inhibiting cardiac fibrosis remains unclear. In this study, we investigate effects of serelaxin on inhibiting cardiac fibrosis....

journal_title：Experimental cell research

authors： Wu XP,Wang HJ,Wang YL,Shen HR,Tan YZ

更新日期：2018-01-01 00:00:00

abstract：:Implantation of myoblasts is a strategy used to enhance the regeneration of skeletal muscle tissue in vivo. In mouse models, myogenic cell lines and primary cells have been employed with different yields of adult muscle tissue formed. The present work is a study of some developmental features of expanded primary mouse...

journal_title：Experimental cell research

authors： Lorenzon P,Bernareggi A,Degasperi V,Nurowska E,Wernig A,Ruzzier F

更新日期：2002-08-01 00:00:00

abstract：:Endocytosis is inhibited by overexpression of either dynamin-1 or dynamin-2 mutants because both isoforms form heterotetramers with endogenous dynamin-2 and interfere with its function. By contrast, other phenotypes, which are specifically triggered by overexpression of dynamin-2, but not dynamin-1 are likely to refle...

journal_title：Experimental cell research

authors： Soulet F,Schmid SL,Damke H

更新日期：2006-11-01 00:00:00

abstract：:Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm. The involvement of LAPs in a wide range of human diseases may be linked to an equally bewildering range of the...

journal_title：Experimental cell research

authors： Schirmer EC,Foisner R

更新日期：2007-06-10 00:00:00

abstract：:We have studied the cytotoxicity of ricin in cells treated with brefeldin A (BFA), which dramatically disrupts the structure of the Golgi apparatus causing Golgi content and membrane to redistribute to the ER. BFA inhibits the cytotoxicity of ricin in Chinese hamster ovary, normal rat kidney, and Vero cells and abolis...

journal_title：Experimental cell research

authors： Yoshida T,Chen CC,Zhang MS,Wu HC

更新日期：1991-02-01 00:00:00

abstract：:Histidine-rich glycoprotein (HRGP) is an abundant heparin-binding plasma protein. We have shown that a fragment released from the central histidine/proline-rich (His/Pro-rich) domain of HRGP blocks endothelial cell migration in vitro and vascularization and growth of murine fibrosarcoma in vivo. The minimal active HRG...

journal_title：Experimental cell research

authors： Lee C,Dixelius J,Thulin A,Kawamura H,Claesson-Welsh L,Olsson AK

更新日期：2006-08-01 00:00:00

abstract：:14-3-3 proteins are a family of homologous eukaryotic molecules with seven distinct isoforms in mammalian cells. Isoforms of 14-3-3 proteins interact with diverse ligands and are involved in the regulation of mitogenesis, cell cycle progression, and apoptosis. However, whether different 14-3-3 isoforms are responsible...

journal_title：Experimental cell research

authors： Subramanian RR,Masters SC,Zhang H,Fu H

更新日期：2001-11-15 00:00:00