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Proteins that associate with lamins: many faces, many functions.

Abstract：

:Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm. The involvement of LAPs in a wide range of human diseases may be linked to an equally bewildering range of their functions, including sterol reduction, histone modification, transcriptional repression, and Smad- and beta-catenin signaling. Many LAPs are likely to be at the center of large multi-protein complexes, components of which may dictate their functions, and a few LAPs have defined enzymatic activities. Here we discuss the definition of LAPs, review their many binding partners, elaborate their functions in nuclear architecture, chromatin organization, gene expression and signaling, and describe what is currently known about their links to human disease.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Schirmer EC,Foisner R

doi

10.1016/j.yexcr.2007.03.012

subject

Has Abstract

pub_date

2007-06-10 00:00:00

pages

2167-79

issue

10

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(07)00120-6

journal_volume

313

pub_type

杂志文章,评审

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