The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery.

abstract：:Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a spectrum of B cell lymphoproliferative disorders ranging from polyclonal B cell activation to B cell lymphomas. While a direct role of Epstein-Barr virus (EBV) is well recognized for most of these lesions, recent findings have suggested that ...

journal_title：Experimental cell research

authors： Colombrino E,Rossi E,Ballon G,Terrin L,Indraccolo S,Chieco-Bianchi L,De Rossi A

更新日期：2004-05-01 00:00:00

abstract：:Drebrin is an actin-binding protein which is expressed at highly levels in neurons. When introduced into fibroblasts, it has been known to bind to F-actin and to cause remodeling of F-actin. Here, we performed a domain analysis of the actin-binding and actin-remodeling activities of drebrin. Various fragments of drebr...

journal_title：Experimental cell research

authors： Hayashi K,Ishikawa R,Kawai-Hirai R,Takagi T,Taketomi A,Shirao T

更新日期：1999-12-15 00:00:00

abstract：:Growth-arrested human normal fibroblasts, TIG-1, initiated DNA synthesis following addition of epidermal growth factor (EGF). Transforming growth factor-beta 1 (TGF-beta 1) by itself had no effect on induction of DNA synthesis. When EGF and TGF-beta 1 were added simultaneously to growth-arrested TIG-1 cells, induction...

journal_title：Experimental cell research

authors： Fukami J,Tsuji K,Ueno A,Ide T

更新日期：1995-01-01 00:00:00

abstract：:The micronucleus of Paramecium tetraurelia normally gives rise to the macronucleus by going through the series of nuclear events of meiosis, mitosis and fusion during sexual reproduction. By transplanting the micronucleus from vegetative cells into early exconjugants, we have persuaded the micronucleus to take a short...

journal_title：Experimental cell research

authors： Mikami K,Ng SF

更新日期：1983-03-01 00:00:00

abstract：:A highly sensitive, kinetically unambiguous assay for alpha-factor-induced delay of cell passage through the "start" step of cell division in yeast is presented. The assay employs perfusion with periodic microscopy to monitor the bud emergence kinetics on the 20% of cells within an exponentially growing population whi...

journal_title：Experimental cell research

authors： Moore SA

更新日期：1987-08-01 00:00:00

abstract：:Increased protein aggregation and altered cell signaling accompany many neurodegenerative diseases including Huntington's disease (HD). Cell stress is counterbalanced by signals mediating cell repair but the identity of these are not fully understood. We show here that the mammalian target of rapamycin (mTOR) pathway ...

journal_title：Experimental cell research

authors： Hyrskyluoto A,Reijonen S,Kivinen J,Lindholm D,Korhonen L

更新日期：2012-01-01 00:00:00

abstract：:Melanotransferrin is a glycoprotein expressed at the cell membrane and secreted in the extracellular environment. Recombinant truncated form of membrane-bound melanotransferrin (sMTf) was reported to exert in vitro anti-angiogenic properties. Here we show that sMTf treatment leads to a 50% inhibition of neovasculariza...

journal_title：Experimental cell research

authors： Rolland Y,Demeule M,Michaud-Levesque J,Béliveau R

更新日期：2007-08-01 00:00:00

abstract：:A monoclonal rat IgM antibody (4C9) raised against F9 embryonal carcinoma cells reacted with fucosyl residues in poly-N-acetyllactosamine-type large carbohydrates of these cells (embryoglycan). The chemical properties and distribution of the antigen resembled those of SSEA-1. The monoclonal antibody was found to inhib...

journal_title：Experimental cell research

authors： Nomoto S,Muramatsu H,Ozawa M,Suganuma T,Tashiro M,Muramatsu T

更新日期：1986-05-01 00:00:00

abstract：:Human lacrimal gland biopsies were serially incubated in chelating and enzymatic solutions. Viable single cells were evaluated for outgrowth in growth factor enriched medium using the following culture substrates: Matrigel, Type I collagen gel with or without fibroblasts, and plastic. Each epithelial outgrowth was cha...

journal_title：Experimental cell research

authors： Yoshino K,Tseng SC,Pflugfelder SC

更新日期：1995-09-01 00:00:00

abstract：:In most existing transgenic mouse models developed for the study of specific genes in the skin, the goal has been to target transgene expression to defined populations of cells in the cutaneous epithelium. Keratin promoters have been especially useful for this purpose. In some instances, however, it may be desirable t...

journal_title：Experimental cell research

authors： Sawicki JA,Morris RJ,Monks B,Sakai K,Miyazaki J

更新日期：1998-10-10 00:00:00

abstract：:The phenotypic transition of smooth muscle cells (SMC) from a contractile to a synthetic state appears to be an early event in the pathogenesis of atherosclerosis. We examined the effects of extracellular matrix components on the phenotypic modulation of rabbit arterial SMC in primary culture by flow cytometry. The re...

journal_title：Experimental cell research

authors： Yamamoto M,Yamamoto K,Noumura T

更新日期：1993-01-01 00:00:00

abstract：:Nucleoporins (Nups) are a large and diverse family of proteins that mediate nucleocytoplasmic transport at interphase of vertebrate cells. Nups also function in mitosis progression. However, whether Nups are involved in oocyte meiosis progression is still rarely known. In this study, we delineated the roles and regula...

journal_title：Experimental cell research

authors： Chen F,Jiao XF,Zhang JY,Wu D,Ding ZM,Wang YS,Miao YL,Huo LJ

更新日期：2018-10-15 00:00:00

abstract：:Drosophila sHSPs (small heat shock proteins) are expressed in the absence of stress in specific regions of the central nervous system and in gonads of young adults flies. In these two organs, the sHSPs show a cell-specific and developmental stage-specific pattern of expression suggesting distinct regulation and functi...

journal_title：Experimental cell research

authors： Marin R,Landry J,Tanguay RM

更新日期：1996-02-25 00:00:00

abstract：:Human and rodent cells undergoing apoptosis were observed to express high levels of a novel 45,000 M(r) protein. The protein, which we have termed apoptosis specific protein (ASP), was found in Burkitt lymphoma (BL) cells and in adenovirus-transformed human and rat embryo cells induced into apoptosis by a variety of s...

journal_title：Experimental cell research

authors： Grand RJ,Milner AE,Mustoe T,Johnson GD,Owen D,Grant ML,Gregory CD

更新日期：1995-06-01 00:00:00

abstract：:Heat shock proteins (hsp) have important roles in the regulation and protection of both prokaryotic and eukaryotic cells, especially during environmental stress. Hsps are also important bacterial virulence factors. We investigated whether bacterial hsp60 can alter epithelial cell mitogen-activated protein kinase (MAPK...

journal_title：Experimental cell research

authors： Zhang L,Pelech SL,Mayrand D,Grenier D,Heino J,Uitto VJ

更新日期：2001-05-15 00:00:00

abstract：:Elevated plasma free fatty acids level has been implicated in the development of insulin resistance, inflammation, and endothelial dysfunction in diabetic and nondiabetic individuals. However, the underlying mechanisms still remain to be defined. Herein, we investigated the effect of palmitic acid (PA), the most abund...

journal_title：Experimental cell research

authors： Wang Y,Wang XJ,Zhao LM,Pang ZD,She G,Song Z,Cheng X,Du XJ,Deng XL

更新日期：2019-10-15 00:00:00

abstract：:The J.774 murine macrophage cells were cultured in suspension in Teflon flasks. When allowed to attach on culture plastic dishes, a 2-3-fold increase in transferrin binding was observed. This occurred in 10 min, reached a steady state at 60 min, remained stable for several hours and was reversible after resuspension o...

journal_title：Experimental cell research

authors： Ventura MA,Louache F,Rouis M,Erlich D,Goldstein S,Testa U,Thomopoulos P

更新日期：1987-06-01 00:00:00

abstract：:The interphase nucleus is a structurally ordered, three-dimensional structure, in which specific chromatin domains occupy distinct spatial positions that can, in turn, be modified with changes in cell function. A fundamental goal in developmental neurobiology is the identification of mechanisms that dictate the orderl...

journal_title：Experimental cell research

authors： Martou G,De Boni U

更新日期：2000-04-10 00:00:00

abstract：:We have studied the effects of the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the contractility, locomotion, morphology, and adhesion of two mammalian fibroblastic cell lines. Using the silicone rubber substratum technique, we have found that the first observable response to the tumor ...

journal_title：Experimental cell research

authors： Danowski BA,Harris AK

更新日期：1988-07-01 00:00:00

abstract：:The process of DNA synthesis in normal and endoreduplicating mammalian cells are very similar. Both types of chromosomes are replicated in defined units termed chromosomal replicons, and in the same sequences along their lengths. The sister chromosomes of the diplochromosomes are replicated synchronously in identical ...

journal_title：Experimental cell research

authors： Lau YF

更新日期：1983-07-01 00:00:00

abstract：:The glycolytic enzyme aldolase is concentrated in a domain around stress fibers in living Swiss 3T3 cells, but the mechanism by which aldolase is localized has not been revealed. We have recently identified a molecular binding site for F-actin on aldolase, and we hypothesized that this specific binding interaction, ra...

journal_title：Experimental cell research

authors： Wang J,Tolan DR,Pagliaro L

更新日期：1997-12-15 00:00:00

abstract：:Mitotic BHK21 cells were examined by immunofluorescence optical sectioning after staining with anti-vimentin. Throughout all stages of mitosis, intact 10-nm filaments were observed to form a cage around the mitotic spindle. These observations were confirmed by serial section electron microscopy which demonstrated asse...

journal_title：Experimental cell research

authors： Blose SH,Bushnell A

更新日期：1982-11-01 00:00:00

abstract：:The structure of a tissue engineering scaffold plays an important role in modulating tissue growth. A novel gelatin-chitosan (Gel-Cs) scaffold with a unique structure produced by three-dimensional printing (3DP) technology combining with vacuum freeze-drying has been developed for tissue-engineering applications. The ...

journal_title：Experimental cell research

authors： Chen H,Liu Y,Jiang Z,Chen W,Yu Y,Hu Q

更新日期：2014-05-01 00:00:00

abstract：:Cell-matrix adhesion complexes are multi-protein structures linking the extracellular matrix (ECM) to the cytoskeleton. They are essential to both cell motility and function by bidirectionally sensing and transmitting mechanical and biochemical stimulations. Several types of cell-matrix adhesions have been identified ...

journal_title：Experimental cell research

authors： Li Z,Lee H,Zhu C

更新日期：2016-11-15 00:00:00

abstract：:Transforming growth factor beta regulates many biological processes including cell motility and invasion. Podosomes are specialized F-actin rich structures found in normal cells, such as osteoclasts and macrophages. Tumor cells often form related structures called invadopodia that are thought to promote invasion and m...

journal_title：Experimental cell research

authors： Mandal S,Johnson KR,Wheelock MJ

更新日期：2008-11-15 00:00:00

abstract：:We found that a transient rise in cGMP levels, which was closely associated with the Ca2+ influx, occurred concomitant with the onset of myoblast fusion. The Ca2+ channel blocker D600 decreased both the cell fusion and the normal rise in cGMP levels. In contrast, the Ca2+ ionophore A23187 transiently increased cGMP le...

journal_title：Experimental cell research

authors： Choi SW,Baek MY,Kang MS

更新日期：1992-03-01 00:00:00

abstract：:Whey Acidic Protein (WAP) gene expression is specific to the mammary gland and regulated by lactogenic hormones to peak during lactation. It differs markedly from the more constitutive expression of the two flanking genes, Ramp3 and Tbrg4. Our results show that the tight regulation of WAP gene expression parallels var...

journal_title：Experimental cell research

authors： Montazer-Torbati MB,Hue-Beauvais C,Droineau S,Ballester M,Coant N,Aujean E,Petitbarat M,Rijnkels M,Devinoy E

更新日期：2008-03-10 00:00:00

abstract：:Phosphoinositide 3-kinases (PI3Ks) are an evolutionary conserved family of lipid kinases that control cell growth, metabolism and survival. By generating lipid second messengers that interact with specialized lipid-binding domains found in a wide spectrum of signaling molecules, PI3Ks instigate signaling through a net...

journal_title：Experimental cell research

authors： Graupera M,Potente M

更新日期：2013-05-15 00:00:00

abstract：:The rapidity of the optional 90-min differentiation of Naegleria gruberi from amoebae to flagellates suggests the possibility of a free-running cascade of events from initiating stimulus through gene expression to organelle assembly and cell morphogenesis. Instead our experiments reveal two points early in the differe...

journal_title：Experimental cell research

authors： Fulton C,Lai EY

更新日期：1998-08-01 00:00:00

abstract：:Formation of the neural tube is the morphological hallmark for development of the embryonic central nervous system (CNS). Therefore, neural tube development is a crucial step in the neurulation process. Slit/Robo signaling was initially identified as a chemo-repellent that regulated axon growth cone elongation, but it...

journal_title：Experimental cell research

authors： Wang G,Li Y,Wang XY,Han Z,Chuai M,Wang LJ,Ho Lee KK,Geng JG,Yang X

更新日期：2013-05-01 00:00:00