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Exchange of chemical signals between cardiac cells. Fundamental role on cell communication and metabolic cooperation.

Abstract：

:The exchange of chemical signals between cardiac cells and its relevance for cell communication and metabolic cooperation was reviewed. The role of gap junctions on the transfer of chemical information was discussed as well as the different factors involved in its regulation including changes in cell volume, high glucose, activation of the renin angiotensin aldosterone system including the intracrine effect of renin and angiotensin II on chemical coupling and cardiac energetics. Finally, the possible role of epigenetic changes of the renin angiotensin aldosterone system (RAAS) on the expression of components of the RAAS was discussed. The evidence available leads to the conception of the heart as a metabolic syncytium in which glucose as well nucleotides and hormones can flow from cell-to-cell though gap junctions, providing a new vision of how alterations in metabolic cooperation can induce cardiac diseases. These findings represent a stimulus for future research in this important area of cardiac physiology and pathology.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

De Mello WC

doi

10.1016/j.yexcr.2016.05.009

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

130-6

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(16)30113-6

journal_volume

346

pub_type

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