Human autoantibody to topoisomerase II.

abstract：:DRnm23 belongs to a multigene family which includes nm23-H1, the first bona fide metastasis suppressor gene, nm23-H2, nm23-H4, and nm23-H5. Like nm23-H1, nm23-H2, and nm23-H4, DRnm23 possesses nucleoside diphosphate kinase (NDPK) activity. Upon overexpression in myeloid precursor 32Dcl3 cells, DRnm23 inhibits granuloc...

journal_title：Experimental cell research

authors： Venturelli D,Cesi V,Ransac S,Engelhard A,Perrotti D,Calabretta B

更新日期：2000-06-15 00:00:00

abstract：:Prior incubation of confluent, quiescent cultures of Swiss 3T3 cells with insulin leads to a selective loss of mitogenic stimulation on re-addition of the combination of vasopressin and insulin in serum-free medium. The desensitization is specific for the action of vasopressin as insulin is fully active in the refract...

journal_title：Experimental cell research

authors： Collins MK,Rozengurt E

更新日期：1984-04-01 00:00:00

abstract：:Replication protein A (RPA), a stable complex of three polypeptides, is the single-stranded DNA-binding protein essential for DNA replication in eukaryotic cells. Previous studies of the subcellular distribution and stability of the RPA heterotrimer during the mammalian cell cycle have produced conflicting results. He...

journal_title：Experimental cell research

authors： Dimitrova DS,Gilbert DM

更新日期：2000-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockou...

journal_title：Experimental cell research

authors： Petri R,Malmevik J,Fasching L,Åkerblom M,Jakobsson J

更新日期：2014-02-01 00:00:00

abstract：:The objective of this study was to explore the potential use of self-assembled monolayers (SAMs) of alkylamine and arylalkyamine as well-defined, homogeneous, tailored in vitro model surfaces for exploring the effect of hydrodynamic flow on morphology and strength of adhesion of human umbilical vein endothelial cells....

journal_title：Experimental cell research

authors： Kapur R,Rudolph AS

更新日期：1998-10-10 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) can modulate the activity of various MAP kinases. However, how this pathway may mediate TGFbeta-induced malignant phenotypes remains elusive. We investigated the role of autocrine TGFbeta signaling through MAP kinases in the regulation of cell survival in breast carcinoma MCF-...

journal_title：Experimental cell research

authors： Lei X,Yang J,Nichols RW,Sun LZ

更新日期：2007-05-01 00:00:00

abstract：:Neurons require adhesive scaffolds for their growth and differentiation. Laminins are a major cell adhesive component of basement membranes and have various biological activities in the peripheral and central nervous systems. Here, we evaluated the biological activities of 5 peptides derived from laminin-111 as a scaf...

journal_title：Experimental cell research

authors： Hayashi H,Horinokita I,Yamada Y,Hamada K,Takagi N,Nomizu M

更新日期：2020-12-22 00:00:00

abstract：:Wnt proteins are important regulators of embryonic development, and dysregulated Wnt signalling is involved in the oncogenesis of several human cancers. Our knowledge of the downstream target genes is limited, however. We used a chromatin immunoprecipitation-based assay to isolate and characterize the actual gene segm...

journal_title：Experimental cell research

authors： Railo A,Pajunen A,Itäranta P,Naillat F,Vuoristo J,Kilpeläinen P,Vainio S

更新日期：2009-10-01 00:00:00

abstract：:Nucleoporins (Nups) are a large and diverse family of proteins that mediate nucleocytoplasmic transport at interphase of vertebrate cells. Nups also function in mitosis progression. However, whether Nups are involved in oocyte meiosis progression is still rarely known. In this study, we delineated the roles and regula...

journal_title：Experimental cell research

authors： Chen F,Jiao XF,Zhang JY,Wu D,Ding ZM,Wang YS,Miao YL,Huo LJ

更新日期：2018-10-15 00:00:00

abstract：:Micro(mi)RNAs play important and varied roles in tumorigenesis; however, the full repertoire of miRNAs that affect cancer cell growth is not known. In this study, an miRNA library was screened to identify those that affect the growth of A549 tumor cells. Among 300 miRNAs, miR-28-5p, -323-5p, -510-5p, -552-3p, and -608...

journal_title：Experimental cell research

authors： Choi YC,Yoon S,Byun Y,Lee G,Kee H,Jeong Y,Yoon J,Baek K

更新日期：2015-12-10 00:00:00

abstract：:Activin A belongs to the superfamily of transforming growth factor beta (TGFβ) and is a critical regulatory cytokine in breast cancer and inflammation. However, the role of activin A in migration of breast cancer cells and immune cells was not well characterized. Here, a microfluidic device was used to examine the eff...

journal_title：Experimental cell research

authors： Xie D,Liu Z,Wu J,Feng W,Yang K,Deng J,Tian G,Santos S,Cui X,Lin F

更新日期：2017-08-01 00:00:00

abstract：:Breast cancer is the most common carcinoma that metastasizes to bone. Tumor-produced parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption, is a major mediator of the osteolytic process in breast cancer. We have previously shown that PTHrP increases breast cancer cell prolifer...

journal_title：Experimental cell research

authors： Shen X,Falzon M

更新日期：2006-11-15 00:00:00

abstract：:It has been suggested that DNA organized into replication foci during S-phase remains stably aggregated in non-S-phase cells and that these stable aggregates provide fundamental units of nuclear or chromosome architecture [C. Meng and R. Berezney (1991) J. Cell Biol. 115, 95a; E. Sparvoli et al. (1994) J. Cell Sci. 10...

journal_title：Experimental cell research

authors： Zink D,Bornfleth H,Visser A,Cremer C,Cremer T

更新日期：1999-02-25 00:00:00

abstract：:The double-stranded RNA-dependent kinase, PKR, is encoded by an interferon inducible gene and is largely responsible for the anti-viral effects of this cytokine. Recent studies have shown that PKR may also play a role in the regulation of normal cellular growth. Although numerous examples of viral strategies for inact...

journal_title：Experimental cell research

authors： Abraham N,Jaramillo ML,Duncan PI,Méthot N,Icely PL,Stojdl DF,Barber GN,Bell JC

更新日期：1998-11-01 00:00:00

abstract：:The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. Cell therapy approaches using human hepatocytes or stem cell-derived hepatocyte-like cells may be a therapeutic option out of this dilemma. ABCB5-po...

journal_title：Experimental cell research

authors： Tietze L,Winkler S,Hempel M,Kluth MA,Tappenbeck N,Ganss C,Dooley S,Christ B

更新日期：2018-08-15 00:00:00

abstract：:Keratinocytes in human skin undergo apoptosis during various inflammatory processes and after ultraviolet (UV) irradiation. To determine if keratinocyte apoptosis may be mediated by the Fas/APO-1 receptor (CD95), a signal transduction pathway known to initiate programmed cell death of lymphocytes, we investigated Fas ...

journal_title：Experimental cell research

authors： Leverkus M,Yaar M,Gilchrest BA

更新日期：1997-05-01 00:00:00

abstract：:In this study we have analyzed short- and long-term changes in extracellular signal-regulated kinase (ERK) 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of human promyelocytic leukemia cells. Immunoprecipitation of HL-60 cellular extracts with an ERK antibody followed by in...

journal_title：Experimental cell research

authors： Meighan-Mantha RL,Wellstein A,Riegel AT

更新日期：1997-08-01 00:00:00

abstract：:Breast cancer is a common malignancy and a major cause of death in women worldwide. The immunomodulatory role of B cells is being increasingly recognized in autoimmune diseases and cancers. In recent years, immunotherapeutic strategies that upregulate the patient's own antitumor T cell responses have shown promise in ...

journal_title：Experimental cell research

authors： Zhu S,Wang X,Wang J,Lin J,Cong Y,Qiao G

更新日期：2017-12-01 00:00:00

abstract：:The existing cytometric methodologies do not allow one to directly correlate, within the same cells, functional cell attributes that are revealed supravitally with features that require cell fixation to be detected or measured. Taking advantage of the "file merge" feature of the laser-scanning cytometer, we have been ...

journal_title：Experimental cell research

authors： Li X,Darzynkiewicz Z

更新日期：1999-06-15 00:00:00

abstract：:Xenopus early embryos are transcriptionally quiescent until the midblastula transition (MBT). We have examined the question of whether the absence of rRNA synthesis is related to a deficiency in the RNA polymerase I (pol I) transcription machinery. Previously we have demonstrated that the maternally provided pol I tra...

journal_title：Experimental cell research

authors： Bell P,Scheer U

更新日期：1999-04-10 00:00:00

abstract：:The extraocular muscles (EOM) are spared from pathology in aging and many forms of muscular dystrophy. Despite many studies, this sparing remains an enigma. The EOM have a distinct embryonic lineage compared to somite-derived muscles, and we have shown that they continuously remodel throughout life, maintaining a popu...

journal_title：Experimental cell research

authors： Kallestad KM,Hebert SL,McDonald AA,Daniel ML,Cu SR,McLoon LK

更新日期：2011-04-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) were recently identified as having significant clinical potential in reversing β-cell functional inhibition caused by inflammation, a shared precursor of Type 1 and Type 2 diabetes. However, HDACi are highly complex and little is known of their direct effect on important cell sec...

journal_title：Experimental cell research

authors： Tiernan AR,Champion JA,Sambanis A

更新日期：2015-01-01 00:00:00

abstract：:Cells undergoing apoptosis are recognized and rapidly phagocytosed by macrophages before their degradation, thus preventing the inflammatory reaction and protecting tissues from the damaging effects of released potentially harmful intracellular contents. In spite of growing interest in the mechanisms leading to the en...

journal_title：Experimental cell research

authors： Falasca L,Bergamini A,Serafino A,Balabaud C,Dini L

更新日期：1996-04-10 00:00:00

abstract：:We investigated the ability of endocytosed activated epidermal growth factor receptors (EGFR) to induce expression of the cyclin-interacting protein p21/CIP1 in A431 cells. Transforming growth factor alpha (TGFalpha) and EGF both induced tyrosine phosphorylation, induction of p21/CIP1, and thereby inhibition of DNA sy...

journal_title：Experimental cell research

authors： Skarpen E,Johannessen LE,Bjerk K,Fasteng H,Guren TK,Lindeman B,Thoresen GH,Christoffersen T,Stang E,Huitfeldt HS,Madshus IH

更新日期：1998-08-25 00:00:00

abstract：:tsJT60, a temperature-sensitive (ts) cell-cycle mutant of Fischer rats, is viable at both the permissive (34 degrees C) and nonpermissive (40 degrees C) temperatures. The cells grow normally in exponential growth phase at both temperatures, but when stimulated with serum from G0 phase they enter S phase at 34 degrees ...

journal_title：Experimental cell research

authors： Tai YY,Goto Y,Ninomiya-Tsuji J,Kameoka Y,Ishibashi S,Shiroki K,Ide T

更新日期：1988-11-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) binding to ocular tissues has been studied by autoradiographical and biochemical approaches directly performed on sections during mouse embryonic and postnatal development. Frozen sections of embryos (9 to 18 days), newborns, and adults (1 day to 6 months) were incubated with iodi...

journal_title：Experimental cell research

authors： Fayein NA,Courtois Y,Jeanny JC

更新日期：1990-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) induces apoptosis in fetal rat hepatocytes. However, a subpopulation of these cells survives concomitant with changes in morphology and phenotype, reminiscent of an epithelial mesenchymal transition (EMT) [Exp. Cell Res. 252 (1999) 281-291]. In this work, we have isolated the...

journal_title：Experimental cell research

authors： Valdés F,Murillo MM,Valverde AM,Herrera B,Sánchez A,Benito M,Fernández M,Fabregat I

更新日期：2004-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are multifunctional signaling molecules that have gained increasing interest in cancer research. To obtain a systematic view on BMP signaling in pancreatic cancer we first determined the mRNA expression levels of seven BMP ligands (BMP2-BMP8) and six BMP specific receptors in pancrea...

journal_title：Experimental cell research

authors： Virtanen S,Alarmo EL,Sandström S,Ampuja M,Kallioniemi A

更新日期：2011-09-10 00:00:00

abstract：:In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines. We found IC(50) values in t...

journal_title：Experimental cell research

authors： Köster M,Lykke-Andersen S,Elnakady YA,Gerth K,Washausen P,Höfle G,Sasse F,Kjems J,Hauser H

更新日期：2003-06-10 00:00:00

abstract：:Dominant mutations in presenilin1 (PS1) and presenilin2 (PS2) are a major cause of early-onset Alzheimer's disease. In this report we analyze the expression of the zebrafish presenilin1 (Psen1) and presenilin2 (Psen2) proteins during embryogenesis. We demonstrate that Psen1 and Psen2 holoproteins are relatively abunda...

journal_title：Experimental cell research

authors： Nornes S,Groth C,Camp E,Ey P,Lardelli M

更新日期：2003-09-10 00:00:00