Abstract：
:Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 +/- 0.35 vs. 0.19 +/- 0.08 U/mg protein; p less than 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Garewal HS,Sampliner R,Gerner E,Steinbronn K,Alberts D,Kendall Ddoi
10.1016/0016-5085(88)90259-4subject
Has Abstractpub_date
1988-03-01 00:00:00pages
819-21issue
3eissn
0016-5085issn
1528-0012pii
0016-5085(88)90259-4journal_volume
94pub_type
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