Abstract:
:Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred within 2 months of ingesting tetracyclines in two female patients. Serum bilirubin levels normalized 12 and 34 months after tetracycline ingestion. Liver histology revealed bile duct paucity, severe cholestasis, and minimal necrosis and inflammation. Tetracyclines may infrequently induce bile duct paucity and prolonged, severe, and reversible cholestasis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Hunt CM,Washington Kdoi
10.1016/0016-5085(94)90830-3subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1844-7issue
6eissn
0016-5085issn
1528-0012pii
S0016508594003847journal_volume
107pub_type
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