Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon.

abstract：:Inferior mesenteric arterial blood flow was measured with an electromagnetic blood flowmeter in five anesthetized rhesus monkeys. The effects of vasopressin on this vasculature were determined to evaluate the optimal, safe concentration of this agent during its clinical application in the management of hemorrhagic les...

journal_title：Gastroenterology

authors： Kerr JC,Hobson RW 2nd,Seelig RF,Swan KG

更新日期：1977-03-01 00:00:00

abstract：:Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...

journal_title：Gastroenterology

authors： Linden A,Eriksson M,Carlquist M,Uvnäs-Moberg K

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND & AIMS:This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C virus (HCV) serostatus, and explored the possible joint influence of obesity/diabetes and HBV/HCV infec...

journal_title：Gastroenterology

authors： Chen CL,Yang HI,Yang WS,Liu CJ,Chen PJ,You SL,Wang LY,Sun CA,Lu SN,Chen DS,Chen CJ

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...

journal_title：Gastroenterology

authors： Wang JH,Ahn IS,Fischer TD,Byeon JI,Dunn WA Jr,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS:We studied growth failure and its relationship to disease activi...

journal_title：Gastroenterology

authors： Motil KJ,Grand RJ,Davis-Kraft L,Ferlic LL,Smith EO

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...

journal_title：Gastroenterology

authors： Lo Sasso G,Bovenga F,Murzilli S,Salvatore L,Di Tullio G,Martelli N,D'Orazio A,Rainaldi S,Vacca M,Mangia A,Palasciano G,Moschetta A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...

journal_title：Gastroenterology

authors： Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

更新日期：2012-04-01 00:00:00

abstract：:The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...

journal_title：Gastroenterology

authors： Pawlotsky JM,Chevaliez S,McHutchison JG

更新日期：2007-05-01 00:00:00

abstract：:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...

journal_title：Gastroenterology

authors： Newcomer AD,Gordon H,Thomas PJ,McGill DB

更新日期：1977-11-01 00:00:00

abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

journal_title：Gastroenterology

authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND & AIMS:The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial. Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV. METHODS:U...

journal_title：Gastroenterology

authors： Forman LM,Lewis JD,Berlin JA,Feldman HI,Lucey MR

更新日期：2002-04-01 00:00:00

abstract：:Three generations of a kindred comprising 50 individuals are described in which recurrent intrahepatic cholestasis of pregnancy has occurred with high frequency. A uniform expression and complete penetrance of the trait in the women of a limited "affected" portion of the kindred (6 affected of 10 women), along with th...

journal_title：Gastroenterology

authors： Holzbach RT,Sivak DA,Braun WE

更新日期：1983-07-01 00:00:00

abstract：:A newly recognized clinical and morphologic pattern of acute alcoholic liver disease is described. Twenty-one patients, having the hepatic morphologic features of alcoholic foamy degeneration, were retrospectively analyzed. All patients had a significant history of chronic alcoholism. Jaundice and hepatomegaly were us...

journal_title：Gastroenterology

authors： Uchida T,Kao H,Quispe-Sjogren M,Peters RL

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of anal cancer is higher in patients with anal canal condyloma, a sexually transmitted disease, than in the general population. We determined the prevalence of anal dysplasia and cancer in patients with anal canal condyloma with respect to human immunodeficiency virus (HIV) status, immun...

journal_title：Gastroenterology

authors： Sobhani I,Vuagnat A,Walker F,Vissuzaine C,Mirin B,Hervatin F,Marmuse JP,Crémieux AC,Carbon C,Henin D,Lehy T,Mignon M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND & AIMS:Advanced pancreatic carcinoma has a dismal prognosis despite extensive chemotherapeutic trials. The aim of this study was to evaluate the role of retinoids as an experimental therapeutic approach for pancreatic cancer. METHODS:Four ductal and one acinar pancreatic tumor cell lines were investigated. ...

journal_title：Gastroenterology

authors： Rosewicz S,Stier U,Brembeck F,Kaiser A,Papadimitriou CA,Berdel WE,Wiedenmann B,Riecken EO

更新日期：1995-11-01 00:00:00

abstract：:There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...

journal_title：Gastroenterology

authors： Tilg H,Moschen AR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS:We...

journal_title：Gastroenterology

authors： Dietz J,Susser S,Vermehren J,Peiffer KH,Grammatikos G,Berger A,Ferenci P,Buti M,Müllhaupt B,Hunyady B,Hinrichsen H,Mauss S,Petersen J,Buggisch P,Felten G,Hüppe D,Knecht G,Lutz T,Schott E,Berg C,Spengler U,von Ha

更新日期：2018-03-01 00:00:00

abstract：:We studied the influence of morphine on intestinal secretion induced by three different secretogogues in an attempt to elucidate the mechanism for its antisecretory activity. In rabbit ileal mucosa in vitro morphine (10(-4) M) did not influence the electrical response to the subsequent administration of prostaglandin ...

journal_title：Gastroenterology

authors： McKay JS,Linaker BD,Higgs NB,Turnberg LA

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...

journal_title：Gastroenterology

authors： Hillebrandt S,Goos C,Matern S,Lammert F

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND & AIMS:The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cyt...

journal_title：Gastroenterology

authors： van der Zanden EP,Snoek SA,Heinsbroek SE,Stanisor OI,Verseijden C,Boeckxstaens GE,Peppelenbosch MP,Greaves DR,Gordon S,De Jonge WJ

更新日期：2009-09-01 00:00:00

abstract：:Infliximab, the chimeric monoclonal immunoglobulin (Ig)G1 antibody to tumor necrosis factor (TNF) has changed our therapy of Crohn's disease. Infliximab is indicated in refractory luminal and fistulizing Crohn's disease. In patients with luminal disease, a single intravenous (i.v.) dose of 5 mg/kg is efficacious; in f...

journal_title：Gastroenterology

authors： Rutgeerts P,Van Assche G,Vermeire S

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND & AIMS:Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC). METHODS:CAC was induced in VEGFR2(ΔIEC) mice, which do...

journal_title：Gastroenterology

authors： Foersch S,Sperka T,Lindner C,Taut A,Rudolph KL,Breier G,Boxberger F,Rau TT,Hartmann A,Stürzl M,Wittkopf N,Haep L,Wirtz S,Neurath MF,Waldner MJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhyd...

journal_title：Gastroenterology

authors： El-Omar EM,Oien K,Murray LS,El-Nujumi A,Wirz A,Gillen D,Williams C,Fullarton G,McColl KE

更新日期：2000-01-01 00:00:00

abstract：:A rapid immunohistochemical method using 5'-bromo-2'-deoxyuridine (BrdU), a thymidine analog, for labeling proliferating epithelial cells was modified and tested for accuracy against standard tritiated thymidine autoradiography (3H-TdR) in rat esophagus, stomach, duodenum, and colon. Either BrdU or 3H-thymidine or bot...

journal_title：Gastroenterology

authors： Lacy ER,Kuwayama H,Cowart KS,King JS,Deutz AH,Sistrunk S

更新日期：1991-01-01 00:00:00

abstract：:Several experimental studies have demonstrated that activated intestinal T cells can induce villous atrophy. This observation led us to examine the possible role of activated T cells in the pathogenesis of intestinal lesions in a group of 13 children with intractable diarrhea and villous atrophy of unknown origin. Imm...

journal_title：Gastroenterology

authors： Cuenod B,Brousse N,Goulet O,De Potter S,Mougenot JF,Ricour C,Guy-Grand D,Cerf-Bensussan N

更新日期：1990-10-01 00:00:00

abstract：:We have developed an isolated intestinal cell system to study the regulation of cholecystokinin release. Enzymatically dispersed canine jejunal mucosal cells were separated by counterflow elutriation to enrich cholecystokinin content 20-fold. Release of cholecystokinin from freshly isolated cells was determined by rad...

journal_title：Gastroenterology

authors： Barber DL,Walsh JH,Soll AH

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND & AIMS:Acute pancreatitis (AP) is characterized by severe inflammation and acinar cell death. Transmembrane protein 173 (TMEM173 or STING) is a DNA sensor adaptor protein on immune cells that recognizes cytosolic nucleic acids and transmits signals that activate production of interferons and the innate immun...

journal_title：Gastroenterology

authors： Zhao Q,Wei Y,Pandol SJ,Li L,Habtezion A

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Surgical management of pancreatic cancer depends on tumor resectability and staging. This study evaluated a new in vivo technique, fiberoptic confocal fluorescence microscopy (FCFM), for detection and staging of pancreatic tumors in rats. METHODS:FCFM was used with a protease-activated fluorescent ma...

journal_title：Gastroenterology

authors： Ignat M,Aprahamian M,Lindner V,Altmeyer A,Perretta S,Dallemagne B,Mutter D,Marescaux J

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND & AIMS:Glutamine is an essential amino acid for rapidly dividing cells such as enterocytes. The progress of cancer is associated with a decrease of arterial and muscle glutamine concentrations. The aim of this study was to test whether increasing tumor loads affect gut intracellular glutamine handling, prote...

journal_title：Gastroenterology

authors： De Blaauw I,Deutz NE,van der Hulst RR,von Meyenfeldt MF

更新日期：1997-01-01 00:00:00